(5R-Cis)-Toluene-4-Sulfonic Acid 5-(2,4-Difluorophenyl)-5-(1H-1,2,4–Triazol-1-Yl)Methyltetrahydrofuran-3-Yl Methyl Ester

The chemical structure of (5R-cis) -p-toluenesulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazole-1-yl) methyltetrahydrofuran-3-yl methyl ester is just like the delicate map contained in ancient books. This compound has a unique structure.
At one end, it is the p-toluenesulfonic acid root, which is like the cornerstone of ancient buildings, on the side of the stable structure. The p-toluenesulfonic acid part, above the benzene ring, the methyl and sulfonic acid groups occupy specific positions, echoing each other, like the layout of pavilions and pavilions, are scattered.
In the main chain, the tetrahydrofuran ring is like a delicate ring. At the 5 positions on the ring, (2,4-difluorophenyl) is cleverly connected, and the fluorine atom is at a specific position in the benzene ring, giving this structure a unique characteristic, which is like an accessory. And the 5 positions are also connected with (1H-1,2,4-triazole-1-yl) methyl. The triazole ring has a unique structure, which is connected to the methyl group with 1-base, and then connected to the tetrahydrofuran ring, which seems to be a silk string bead.
As for the 3 positions, there is a methyl ester group connected, which is like the tail of the ring, which adds a touch of refinement to the overall structure. In this way, the various parts of the structure are interconnected to build this complex and delicate chemical structure, which is like a quaint and delicate picture scroll, revealing its unique beauty in the microscopic world.

(5R-cis) -p-toluenesulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazole-1-yl) methyltetrahydrofuran-3-yl methyl ester, this compound is widely used. In the field of pharmaceutical research and development, it can be used as a key intermediate for active pharmaceutical ingredients. Through subtle chemical modifications and reactions, it is expected to create drugs with novel pharmacological activities, which can treat specific diseases or have unique effects. For some infectious diseases, it may be able to precisely act on the key targets of pathogens by virtue of its special structure, interfering with their metabolism or reproduction process, and achieving therapeutic purposes.
In the field of organic synthetic chemistry, it can be used as a very important synthetic building block. Due to its complex and unique structure, it can provide rich reaction check points for organic synthesis chemists. Through various organic reactions, such as nucleophilic substitution, electrophilic addition, etc., more complex and diverse organic molecular structures can be built, which can help the synthesis of new materials, fine chemicals, etc.
In the field of agricultural chemistry, it may also have potential applications. Or it can be used as a lead compound, after structural optimization, to develop new pesticides, which show efficient control effects on crop pests, pathogens, etc. At the same time, due to structural characteristics, it may have good environmental compatibility, which can ensure agricultural production while reducing negative impact on the environment.

The synthesis of (5R-cis) -p-toluenesulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazole-1-yl) methyltetrahydrofuran-3-yl methyl ester is described below.
To prepare this compound, a suitable starting material is first taken, which is based on 2,4-difluorobenzaldehyde, and it is condensed with a specific nitrogen-containing heterocyclic compound, that is, a 1,2,4-triazole derivative. This step requires a suitable solvent, such as absolute ethanol or dichloromethane, adding an appropriate amount of base as a catalyst, such as potassium carbonate or sodium hydroxide, controlling the temperature in a moderate range, about 20 to 30 degrees Celsius, and stirring for several times to promote the full reaction of the key intermediates.
Then, this intermediate is interacted with tetrahydrofuran-3-ol derivatives. This reaction requires specific reaction conditions, using p-toluenesulfonyl chloride as an esterification reagent, in an alkaline environment such as pyridine or triethylamine, at a low temperature such as 0 to 5 degrees Celsius, slowly add the reagent and stir to esterify the hydroxyl group and p-toluenesulfonyl group to form an important precursor.
Subsequently, this important precursor is combined with a methylation agent, such as iodomethane or dimethyl sulfate, in a suitable solvent, such as N, N - dimethylformamide, under basic conditions, such as sodium hydride or potassium tert-butyl alcohol in the presence of heating to about 50 to 60 degrees Celsius, causing a methylation reaction to occur to obtain the target product (5R - cis) - p-toluenesulfonate 5- (2,4 - difluorophenyl) - 5- (1H - 1,2,4 - triazole - 1 - yl) methyltetrahydrofuran - 3 - yl methyl ester. After the reaction is completed, the pure product is obtained by conventional separation and purification methods such as extraction and column chromatography. The whole synthesis process requires fine control of the reaction conditions at each step to ensure the smooth progress of the reaction and improve the yield and purity of the product.

(5R-cis) -p-toluenesulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazole-1-yl) methyl tetrahydrofuran-3-yl methyl ester. The physical and chemical properties of this substance are detailed for you.
Its appearance is often in a specific state, or in the shape of crystallization, or in the shape of powder, which is related to its molecular arrangement and aggregation state. The color is either white as snow, or slightly yellowish, due to the amount of impurities contained and differences in the preparation process. The melting point of
is one of the key physical properties, and this value reflects the strength of the intermolecular forces. When heated to the melting point of the substance, the molecule is energized enough to overcome the lattice binding and gradually melt from the solid state to the liquid state. Accurate determination of the melting point can help determine its purity. If it contains impurities, the melting point often decreases and the melting range becomes wider.
Solubility is also an important property. In different solvents, its dissolution performance varies. In organic solvents such as ethanol and acetone, or it exhibits good solubility. Due to the interaction between molecules and solvent molecules, hydrogen bonds, van der Waals forces, etc. can be formed, so that the solute molecules are uniformly dispersed in the solvent. However, in water, the solubility may not be good, because the proportion of hydrophobic groups in the molecular structure is relatively large, and the interaction with water molecules is weak.
In terms of stability, under normal conditions, if there is no special condition to trigger, this substance is relatively stable. However, in case of high temperature, strong acid-base or specific catalyst, some chemical bonds in the molecular structure may become active, triggering chemical reactions, causing structural changes, and forming new substances. In case of strong acid, ester bond or hydrolysis, the corresponding acids and alcohols are released.
The physical and chemical properties of this substance are closely related to the molecular structure. The specific functional groups in its structure determine the way of interaction with the external environment, and then exhibit such various properties.

Today, there is (5R-cis) -toluene-4-sulfonic acid 5- (2,4-difluorophenyl) -5 - (1H-1,2,4-triazole-1-yl) methyltetrahydrofuran-3-yl methyl ester. What is the situation in the city? I will imitate the ancient saying and literary style of "Tiangong Kaiwu" for your explanation.
In today's market, (5R-cis) -toluene-4-sulfonic acid 5- (2,4-difluorophenyl) -5 - (1H-1,2,4-triazole-1-yl) methyltetrahydrofuran-3-yl methyl ester is more common in the field of pharmaceutical and chemical industry. It is produced by fine chemicals or used in the manufacture of pharmaceutical intermediates.
In the field of pharmaceutical research and development, this compound is often noticed by researchers because of its unique structure and potential biological activity. It is used as a basis to explore the possibility of creating new drugs. The inter-market supply is mostly produced by professional chemical enterprises, and its quality depends on the coarse craftsmanship of the manufacturer. Excellent production, high purity, less impurities, is favored by pharmaceutical companies and scientific research institutions.
However, it is in the city, and it is also subject to regulations. Chemical products entering the market need to comply with safety, environmental protection and other regulations. Manufacturers who want to sell them must test and declare in accordance with regulations. And because it is a fine chemical, the price may be expensive, and the price is determined, which is related to the cost of raw materials, the simplicity of the production process, and the state of market supply and demand. When the demand is greater than the supply, the price may rise; if the supply exceeds the demand, the price may be suppressed.
And the demand for this product in the market is often related to the rise and fall of the pharmaceutical industry. Therefore, (5R-cis) -toluene-4-sulfonic acid 5- (2,4-difluorophenyl) -5 - (1H-1,2,4-triazole-1-yl) methyl tetrahydrofuran-3-yl methyl ester is in the market scene and depends on many parties. It changes with the change of pharmaceutical and chemical industry.