What is the chemical structure of 8-Chloro-2- (4-Hydroxyphenyl) -4-Azabicyclo [5.4.0] Undeca-7,9,11-Triene-9,10-Diol Methanesulphonate?
8-Chloro-2- (4-hydroxyphenyl) -4-azabicyclo [5.4.0] undecarbon-7,9,11-triene-9,10-diol methanesulfonate, which is a complex organic compound. To clarify its chemical structure, it is necessary to analyze it according to the rules and nomenclature of organic chemistry.
First look at the main structure, "4-azabicyclo [5.4.0] undeca-7,9,11-triene" shows that it has a dicyclic structure, the ring contains eleven carbon atoms, and there are three carbon-carbon double bonds at positions 7, 9, and 11. The nitrogen atom occupies position 4 and is embedded in the dicyclic system, which is the core skeleton of the compound.
Side chain part, "2- (4-hydroxyphenyl) " indicates that there is a phenyl group attached to position 2 of the dicyclic structure, and the phenyl group has a hydroxyl group at position 4, which gives the molecule specific chemical activity and reaction check point.
Furthermore, "8-chlorine" indicates that there is a chlorine atom substitution at position 8 of the dicyclic structure, and the introduction of the chlorine atom affects the polarity and reactivity of the molecule.
"9,10-diol" indicates that there is a hydroxyl group connected at positions 9 and 10 of the dicyclic, and the presence of the hydroxyl group makes the molecule easy to participate in reactions such as hydrogen bonding.
Finally, "methanesulfonate" indicates that the compound forms an ester bond with methanesulfonic acid. Methanesulfonate groups are common in organic synthesis and can be used as leaving groups, which have a profound impact on the reaction path and activity of molecules.
Overall, the complex structure of this compound and the interaction of functional groups in various parts endow it with unique chemical properties and potential applications, such as in the field of medicinal chemistry, where various parts of its structure may synergistically exert pharmacological activity.
What are the main uses of 8-Chloro-2- (4-Hydroxyphenyl) -4-Azabicyclo [5.4.0] Undeca-7,9,11-Triene-9,10-Diol Methanesulphonate?
8-Chloro-2- (4-hydroxyphenyl) -4-azabicyclo [5.4.0] undecarbon-7,9,11-triene-9,10-diol methanesulfonate, which is a rather complex chemical substance. Its main uses are mostly in the field of pharmaceutical research and development.
In the field of pharmaceutical chemistry, such compounds are often used as lead compounds. Due to their unique chemical structure or specific biological activity, they can bind to specific biological targets in the body, such as certain proteins, enzymes or receptors. By interacting with these targets, they may regulate physiological and biochemical processes in the body, thus demonstrating the potential to treat diseases.
For example, in some disease-specific drug screening studies, scientists will chemically modify and optimize such compounds based on their structural properties. The purpose is to enhance their affinity with the target, improve the efficacy of the drug, and reduce adverse reactions and side effects. Through a series of rigorous experiments, such as cell experiments, animal experiments, etc., to evaluate their therapeutic effects in disease models, in order to explore the possibility of them becoming new therapeutic drugs.
In addition, when studying new antibacterial and antiviral drugs, such compounds may also exhibit unique activities due to their special structures, providing new ideas and approaches for combating related pathogens. In conclusion, 8-chloro-2-4-azabicyclo [5.4.0] -7,9,11-triene-9,10-diol methanesulfonate contains many potential uses in the field of pharmaceutical research and development, providing new opportunities and directions for solving human health problems.
What are the physicochemical properties of 8-Chloro-2- (4-Hydroxyphenyl) -4-Azabicyclo [5.4.0] Undeca-7,9,11-Triene-9,10-Diol Methanesulphonate?
8-Chloro-2- (4-hydroxyphenyl) -4-azabicyclo [5.4.0] Eleven-7,9,11-triene-9,10-diol methanesulfonate, this is a complex organic compound. It has many physical and chemical properties, and it is related to its structure and reaction characteristics.
Looking at its structure, chlorine atoms, hydroxyphenyl groups, azabicyclo groups and diol methanesulfonates have specific chemical activities. Chlorine atoms can cause nucleophilic substitution reactions, hydroxyl groups in hydroxyphenyl groups are weakly acidic and can participate in esterification, ether formation and other reactions, and phenyl rings can undergo electrophilic substitution. The azabicyclic structure endows the molecule with a unique spatial conformation and stability, which affects its reactivity and selectivity.
In terms of physical properties, this compound is mostly solid at room temperature, due to the interaction of hydrogen bonds and van der Waals forces between molecules. Its solubility is related to molecular polarity. It contains polar hydroxyl groups and sulfonate groups. It has good solubility in polar solvents such as alcohols and water (or has a certain solubility), but poor solubility in non-polar solvents such as alkanes.
In terms of chemical stability, sensitivity to heat, light, air and other conditions varies. Under high temperature or light, chemical bonds or fracture cause decomposition. In an acid-base environment, it reacts according to different group activities. For example, methanesulfonates are easy to hydrolyze under alkaline conditions.
This compound has complex physical and chemical properties and may have important uses in organic synthesis, medicinal chemistry, etc. The synthesis, separation, storage and other processes need to be properly disposed of according to its characteristics.
What is the preparation method of 8-Chloro-2- (4-Hydroxyphenyl) -4-Azabicyclo [5.4.0] Undeca-7,9,11-Triene-9,10-Diol Methanesulphonate?
To prepare 8 - chloro - 2 - (4 - hydroxyphenyl) - 4 - azabicyclo [5.4.0] undecarbon - 7,9,11 - triene - 9,10 - diol methanesulfonate, the method is as follows:
First take an appropriate amount of 4 - hydroxybenzaldehyde, placed in a clean reactor, dissolved in an organic solvent such as dichloromethane, so that it is uniformly dispersed. In addition, prepare a specific reactant containing a nitrogen-heterobicyclo structure, carefully measured and slowly added to the kettle, and at the same time add an appropriate amount of catalyst. This catalyst needs to be precisely selected according to the reaction characteristics, or it is an organic base, so that the reaction can be carried out gently. Control the temperature in a specific range, or between 30 and 40 degrees Celsius, and continue to stir to make the two fully react. During this process, closely observe the reaction progress, which can be monitored by thin-layer chromatography and other means until the reaction reaches the desired level.
When the reaction is initially completed, carefully transfer the reaction solution to the separation funnel, wash it with appropriate acid and alkali to remove impurities. Then dry it with anhydrous sodium sulfate, and then evaporate under reduced pressure to remove the solvent to obtain a crude product.
Dissolve this crude product in a suitable solvent, such as a mixed solvent of ethanol and water, add methanesulfonic acid, and control the temperature to make the two react, or between 50 and 60 degrees Celsius. After the reaction is completed, cool to room temperature, and crystals can be seen to precipitate. The crystals were collected by filtration with a Brinell funnel and rinsed with a cold solvent to remove surface impurities. The obtained crystals were placed in an oven and dried at a suitable temperature to obtain pure 8-chloro-2- (4-hydroxyphenyl) -4-azabicyclo [5.4.0] undecarbon-7,9,11-triene-9,10-diol methanesulfonate. The whole preparation process requires strict adherence to experimental procedures and attention to safety protection to ensure the purity and yield of the product.
8-Chloro-2- (4-Hydroxyphenyl) -4-Azabicyclo [5.4.0] Undeca-7,9,11-Triene-9,10-Diol Methanesulphonate What are the precautions during use?
8-Chloro-2- (4-hydroxyphenyl) -4-azabicyclo [5.4.0] Undecarbon-7,9,11-triene-9,10-diol methanesulfonate. When using this product, many matters must be paid attention to.
The first thing to know is its properties. This product must have its unique physical and chemical properties. It can be seen in its shape, whether it is a powder or a crystal, and its color is also different. Knowing this is crucial to distinguish its authenticity and determine its purity. Observing its physical properties, such as melting point and solubility, can help confirm whether it is a desired product.
Furthermore, safety matters must not be ignored. It may be toxic to a certain extent, or there is a risk of irritation to the skin, eyes, and respiratory tract. When taking it, it must be fully protected, wearing protective clothing, protective gloves on hands, and protective goggles on eyes to ensure smooth breathing. Operate in a well-ventilated place. If you accidentally touch it, rinse it with a lot of water immediately. If it is serious, seek medical attention immediately.
Storage is also important. When it is based on its chemical properties, choose a suitable environment. Or need a dry, cool place, protected from heat and light, to prevent its deterioration and decomposition. Separate from other chemicals, do not mix, to avoid chemical reactions and cause danger.
Use the dose, and be sure to control it precisely. According to the specific use, experimental design or treatment plan, take it strictly according to the amount. If the dose is too large, it may cause adverse reactions, such as too strong medicine, causing discomfort to the body; if the dose is insufficient, it will be difficult to achieve the expected effect.
Operation steps, follow the established procedures. Whether it is used in laboratory research or industrial production, follow the standard process and cannot be changed. Every step should be meticulously and carefully. If there is any deviation, the results may be very different, or even lead to safety accidents.
Compatibility taboos must also be known in detail. When combined with certain substances, it may cause adverse reactions and generate harmful substances. Before use, be sure to consult relevant information to clarify its compatibility requirements and avoid improper combinations.