What are the main uses of 2-amino-3,5-dimethylbenzenesulfonic acid?
2-% hydroxy-3,5-dimethylbenzoic acid, this is an organic compound. Its main use is quite extensive, in the field of medicine, often used as a key intermediate in drug synthesis. For example, it can participate in the preparation of specific antibacterial and anti-inflammatory drugs, and give drugs unique activities and pharmacological properties through its special chemical structure.
In the field of materials science, it also plays an important role. It can be used to synthesize polymer materials with special properties, such as some smart materials that are sensitive to environmental factors. Due to the presence of hydroxyl and methyl groups in its molecular structure, it can change the physical and chemical properties of materials, such as improving the stability of materials and adjusting the solubility of materials.
In the fine chemical industry, it is also an important raw material. It can be used to prepare high-grade coatings, fragrances and other fine chemicals. In the preparation of coatings, it can improve the film formation, adhesion and weather resistance of coatings; in the synthesis of fragrances, its unique chemical structure may bring a special aroma to fragrances, enhancing the quality and uniqueness of fragrances.
This compound has shown indispensable value in many fields due to the specific arrangement and properties of hydroxyl and methyl groups in its structure, providing a key foundation for the development and production of many products.
What are the physical properties of 2-amino-3,5-dimethylbenzenesulfonic acid?
2-% hydroxy-3,5-dimethylbenzoic acid is an organic compound. It has the following physical properties:
This substance is mostly white to light yellow crystalline powder at room temperature. Looking at its color and shape, the pure color and white matter are pure, but due to impurities, etc., or a light yellow tone, the powder is delicate and the particles are uniform.
The melting point range is about 172-174 ° C. When heated to this temperature range, the substance gradually melts from the solid state to the liquid state. This melting point characteristic is an important basis for identification and purification. When the compound is covered with different purity, the melting point may be slightly offset. The higher the purity, the closer the melting point to the standard range.
The boiling point is about 346.7 ° C. At this temperature, the substance changes from a liquid state to a gaseous state violently, and a large number of molecules obtain enough energy to escape from the liquid surface. The boiling point is also related to the purity of the substance and the external pressure. When the external pressure changes, the boiling point will also change accordingly.
The relative density is about 1.25 (20 ° C). That is, at 20 ° C, the ratio of the density of the substance to the density of water at the same temperature is 1.25, which reflects the characteristics of its unit volume mass. It can be used for the separation and identification of substances and helps to judge its distribution in the mixture.
In terms of solubility, it is slightly soluble in water. Although its molecular structure contains hydrophilic groups such as hydroxyl and carboxyl groups, the presence of methyl groups increases the hydrophobicity of the molecule, resulting in limited solubility in water. But it is soluble in organic solvents such as ethanol, ether, and acetone. The molecular structure of organic solvents is similar to that of 2-% hydroxy-3,5-dimethylbenzoic acid. According to the principle of "similar miscibility", the substance can be well dissolved in it. This property is often used in the process of organic synthesis, separation and purification. For example, the substance is extracted with a suitable organic solvent to achieve separation from other impurities.
What are the chemical properties of 2-amino-3,5-dimethylbenzenesulfonic acid?
2-% hydroxy-3,5-dimethylbenzoic acid is an organic compound with the following chemical properties:
- ** Acidic **: Its molecule contains a carboxyl group (-COOH), which makes the substance acidic. In solution, the carboxyl group can dissociate hydrogen ions (H 🥰), exhibiting the characteristics of an acid and capable of neutralizing with bases. For example, when reacting with sodium hydroxide (NaOH), the hydrogen ion in the carboxyl group combines with the hydroxide ion (OH) to form water, resulting in the corresponding carboxylate and water. The reaction equation is: 2-hydroxy-3,5-dimethylbenzoic acid + NaOH → 2-hydroxy-3,5-dimethylbenzoate sodium + H2O O.
- ** Hydroxy reaction **: The intramolecular hydroxyl group (-OH) can participate in many reactions. One is esterification reaction. Under acid catalysis, the hydroxyl group can react with carboxylic acid to form esters. For example, under concentrated sulfuric acid catalysis and heating conditions, the corresponding esters and water are formed with acetic acid. At the same time, the hydroxyl group is affected by the benzene ring, and its hydrogen atom has a certain activity and can be replaced by some nucleophilic reagents.
- ** Benzene ring reaction **: The benzene ring of this compound is aromatic and can undergo electrophilic substitution reaction. Because both hydroxyl and methyl are power supply groups, the electron cloud density of the benzene ring will increase, making it more susceptible to electrophilic attack. Common reactions such as halogenation, in the presence of catalysts such as iron trihalides, benzene rings can be substituted with halogen elements, and halogen atoms replace hydrogen atoms on benzene rings. In addition, electrophilic substitution reactions such as nitration and sulfonation reactions can also occur.
- ** Oxidation Reaction **: The hydroxyl groups in the molecule have certain reductivity and may be oxidized when encountering strong oxidants. The methyl groups of the side chain of the benzene ring can be oxidized to carboxylic groups under specific conditions, such as under the action of the strong oxidant potassium permanganate (KMnO). If the reaction conditions are properly controlled, specific oxidation transitions can be achieved.
What is the synthesis method of 2-amino-3,5-dimethylbenzenesulfonic acid?
To prepare 2-amino-3,5-dimethylbenzoic acid, the following method can be used:
Start with 3,5-dimethylbenzoic acid as raw material. First, 3,5-dimethylbenzoic acid is co-heated with mixed acid (mixture of sulfuric acid and nitric acid), and nitrification is carried out. In this step, because the methyl group on the benzene ring is an ortho-para-position group, the nitro group is mainly introduced in the ortho or para-position of the methyl group, and 3,5-dimethyl-4-nitrobenzoic acid can be obtained.
Then, 3,5-dimethyl-4-nitrobenzoic acid is reduced to an amino group with a suitable reducing agent, such as iron and hydrochloric acid, or hydrogen under the action of a suitable catalyst (such as palladium carbon), to obtain 2-amino-3,5-dimethylbenzoic acid.
Or start from 3,5-dimethyltoluene. First nitrate 3,5-dimethyltoluene to obtain 3,5-dimethyl-4-nitrotoluene. Then oxidize the methyl to a carboxyl group with a mild oxidizing agent, such as potassium permanganate, to obtain 3,5-dimethyl-4-nitrobenzoic acid. In the next step, the target product 2-amino-3,5-dimethylbenzoic acid is obtained by reducing the nitro group as before.
During operation, the reaction conditions should be controlled carefully at each step. For example, in the nitration reaction, temperature and the proportion of mixed acid all affect the yield and purity of the product. In the reduction reaction, the amount of reducing agent, reaction time and temperature are also critical. In this way, it is expected to obtain 2-amino-3,5-dimethylbenzoic acid in a higher yield.
What is the price range of 2-Amino-3,5-dimethylbenzenesulfonic acid in the market?
The price of various drugs in the market often varies with time and place. As for the price of 2-amino-3,5-dimethylbenzoic acid, it is also difficult to determine.
The price of this drug is often affected by many factors. First, the price of raw materials. If the raw material is not easy to obtain, or there is a change in the origin, which causes the price of raw materials to rise, the price of the drug will also rise. Second, the simplicity of the manufacturing process. If the preparation method requires exquisite skills, complex processes, and a lot of manpower and material resources, the price will not be cheap. Third, the supply and demand of the market. If there are many people who want it, but there are few products, the price will rise; conversely, if the supply exceeds the demand, the price will fall.
I have heard that in ordinary times, the price of this medicine per catty may be between tens of gold and hundreds of gold. In case of bad luck, such as natural and man-made disasters causing shortage of raw materials, or sudden increase in demand in the market, the price may be doubled or even several times. There are also those who have reduced the price due to the improvement of manufacturing technology.
Therefore, if you want to know the exact price of this medicine, you should carefully observe the market situation and visit various drug dealers and workshops before you can get it. The market is unstable, and the price is uncertain. Only real-time news can be used as evidence for confirming the price.