What are the main uses of Boc-Peg4-Sulfonic Acid?
Boc-Peg4-Sulfonic Acid is also a chemical substance. Its use is very important in the field of synthesis. In peptide synthesis, it can be used as a support group to maintain specific functions, so that it can follow the direction of the phase, avoid unexpected reactions, and lead to the synthesis of the road.
It also plays an important role in the research of the chemical. Because it contains polyethylene glycol (PEG) segment, it can increase the water solubility of the chemical, and help the biological distribution of the chemical. And the nature of the sulfonic acid group can be used to multiply and react, or to interact with biological macromolecules. On the chemical, it can be a means of the activity and performance of the whole product.
In the realm of materials science, it can be used to modify surface molecules. Its PEG segment can change the hydrophobicity of the surface of the material, and the sulfonic acid group can lead to specific chemical properties, so that the material has special surface activity. It is used in materials with special properties, such as anti-fouling and biocompatible materials. In addition, Boc-Peg4-Sulfonic Acid has its indispensable functions in many fields such as chemical, chemical, and materials. It is an important help for the development of phase research.
What are the physical and chemical properties of Boc-Peg4-Sulfonic Acid?
Boc-Peg4-Sulfonic Acid is a common compound in organic synthesis. Its physical and chemical properties are worth exploring.
Looking at its physical properties, at room temperature, this substance is mostly in a solid state, or in a white to white powder form, which is easy to store and use. Its melting point is also a key characteristic. The melting point range can be known by experimental measurement, which can help synthesizers grasp the reaction temperature conditions. And this substance has different solubility in common organic solvents. In some polar organic solvents such as dichloromethane, N, N-dimethylformamide, it has a certain solubility. This characteristic is very important in the solvent selection of organic synthesis reactions, so that the reaction can be carried out better in the homogeneous system, promoting effective collision between reactant molecules and improving the reaction efficiency.
On its chemical properties, in Boc-Peg4-Sulfonic Acid, the Boc group (tert-butoxycarbonyl) has the function of protecting the amino group. Under suitable conditions, Boc groups can be selectively introduced or removed. This property is widely used in peptide synthesis and other fields to ensure that the amino group is not affected in a specific reaction step. After the desired reaction is completed, the Boc protective group is gently removed to restore the activity of the amino group and participate in the subsequent reaction. The sulfonic acid group (-SO 🥰 H) in the molecule is strongly acidic and can participate in many acid-base reactions and sulfonation reactions. Its acidity can neutralize the compound with the base to generate the corresponding sulfonate. And the sulfonic acid group can participate in some nucleophilic substitution reactions as an electrophilic reagent, providing the possibility for the construction of complex organic molecular structures. The PEG4 segment (polyethylene glycol segment) in this compound endows it with a certain hydrophilicity and flexibility, so that the whole molecule can exhibit a unique conformation in solution, which affects its interaction with other molecules and has potential application value in drug delivery systems.
What is the synthesis method of Boc-Peg4-Sulfonic Acid?
To prepare Boc-Peg4-Sulfonic Acid, the method is as follows:
First take polyethylene glycol (PEG), choose the right number average molecular weight to ensure accurate product. PEG is hydrophilic and has many applications in organic synthesis. PEG is placed in a clean reaction vessel with appropriate protective reagents and dissolved in an anhydrous organic solvent. This solvent needs to be free of interference with the reaction and can dissolve the reactants, such as dichloromethane.
Next, slowly add a reagent containing Boc groups, such as Boc-acid anhydride. During the reaction, the temperature should be controlled in a suitable range, or ice bath or room temperature, depending on the reaction activity. It is often necessary to use a stirrer to promote it to mix evenly. The Boc-acid anhydride reacts with the PEG terminal hydroxyl group to form a Boc-protected PEG intermediate. This step is to protect the hydroxyl group from misreaction in subsequent reactions.
Then take this intermediate and react with the sulfonating reagent, such as chlorosulfonic acid or sulfur trioxide-pyridine complex, under mild conditions. The process needs to be closely monitored. The reaction process can be observed by thin-layer chromatography (TLC) or high-performance liquid chromatography (HPLC). The sulfonating reagent reacts with the PEG chain at a specific position to introduce the sulfonate group, and then the Boc-Peg4-Sulfonic Acid crude product is obtained.
At the end, appropriate separation and purification methods, such as column chromatography, use a silica gel column, and select an eluent to separate the product from impurities, and obtain high-purity Boc-Peg4-Sulfonic Acid. This whole process needs to abide by the operating specifications to avoid water vapor and impurity interference to ensure the quality and yield of the product.
What are the precautions for the storage and transportation of Boc-Peg4-Sulfonic Acid?
Boc - Peg4 - Sulfonic Acid is a reagent commonly used in organic synthesis. When storing and transporting, many matters must be paid attention to.
First storage, this reagent should be placed in a dry and cool place. Because of its specific chemical properties, moisture is prone to deterioration, such as hydrolysis and other reactions, which damage its chemical activity, so a dry environment is essential. Temperature cannot be ignored. Excessive temperature or cause the decomposition of reagents is generally appropriate to be stored in a low temperature environment, such as a refrigerator freezer, to maintain its chemical stability.
As for transportation, packaging must be proper. Because it may be sensitive to vibration and collision, stable packaging can prevent the container from being damaged due to bumps during transportation and cause reagent leakage. And the transportation environment should also be kept dry to avoid moisture intrusion. If the transportation time is long, it is more necessary to pay attention to temperature control, and appropriate thermal insulation measures can be used to prevent excessive temperature fluctuations from affecting the quality of the reagent. Transportation personnel should also be familiar with its chemical properties. In case of emergencies, they can respond in an appropriate manner to ensure the safety of the transportation process, so that the reagent can be delivered to the destination in good condition for subsequent experiments or production use.
What is the market price range for Boc-Peg4-Sulfonic Acid?
The price of Boc - Peg4 - Sulfonic Acid in the city varies according to various reasons. The producers vary, and the quality of the products may vary, so the price varies. The amount of quantity also affects the price. If the purchase quantity is quite large, the price may be slightly reduced; if the quantity is small, the price may increase.
It is common to see that the price per gram purchased in the city may be between tens and hundreds of yuan. However, this is only a rough number, and the actual price may change with the passage of time and the supply and demand of the market. If the raw materials are rare, the cost of making them will increase, and the price will rise; conversely, if the supply exceeds the demand, the price may decrease.
To know the exact price, when visiting various chemical merchants, ask for details. And compare the prices of several companies, you can know the market, and choose those who are cheap and high-quality to buy them, so as to save tariffs. The price range is about tens to hundreds of yuan per gram, but the actual price needs to be checked in detail.