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1. What is the chemical structure of Butane-1,4-Diyl Dimethanesulfonate?
Butane - 1,4 - Diyl Dimethanesulfonate, its chemical structure is composed of the main chain of butane and two methanesulfonate groups connected to the 1,4 positions of butane.
The main chain of butane has four carbon atoms connected in sequence, forming a straight chain structure. This is the basic skeleton of the compound, providing the carbon chain structure and a certain spatial configuration for the whole molecule.
On the 1 and 4 carbon atoms of the main chain of butane, one methanesulfonate group is attached to each. The methanesulfonate ester group structure is -O - SO - CH. Among them, the oxygen atom is covalently connected to the 1 or 4 carbon atoms of butane, and the methanesulfonate group is connected to the butane main chain through the connection of oxygen atoms. The sulfur atom in the methanesulfonate group is connected to two oxygen atoms and a methyl group. The sulfur atom is in the central atomic state, and is connected to one of the two oxygen atoms through a double bond and a single bond to the other oxygen atom, and then connects the methyl group through a single bond.
This chemical structure endows Butane-1,4-Diyl Dimethanesulfonate with specific chemical properties and reactivity, and has its unique uses in organic synthesis and other fields. The presence of two methanesulfonate groups in its structure makes the compound exhibit active reactivity in nucleophilic substitution and other reactions, and can be used as an important reagent for introducing butane-1,4-diyl structures.
2. What are the main uses of Butane-1,4-Diyl Dimethanesulfonate?
Butane - 1,4 - Diyl Dimethanesulfonate (1,4-butanediol dimethylsulfonate) is widely used in the field of pharmaceutical and chemical industry.
First, it is often a key intermediate in the synthesis of drugs. It can participate in many organic reactions and help build complex drug molecular structures. For example, in the creation of some anti-tumor drugs, it can use its unique chemical structure to cleverly combine with other compounds to form ingredients with specific pharmacological activities.
Second, it can also be used in the field of materials science. It can be used to prepare special polymer materials. With its reactivity, cross-linking structures are formed between polymer chains, thereby improving the properties of materials, such as improving the mechanical strength and heat resistance of materials, to meet the needs of special scenarios.
Third, in the path of organic synthetic chemistry, it provides an effective way to construct carbon-carbon bonds or carbon-hetero bonds. Through carefully designed reaction processes, it can react with various nucleophiles, expand the structural diversity of organic molecules, and lay the foundation for the research and development of new compounds.
With its unique chemical properties, this substance plays an indispensable role in various fields, promoting the progress and development of medicine, materials and other industries.
3. What are the precautions for Butane-1,4-Diyl Dimethanesulfonate during storage and transportation?
Butane-1,4-dimethyl sulfonate, when storing and transporting, pay attention to many matters.
This substance has certain chemical activity. When storing, the temperature and humidity of the environment should be the first priority. It should be stored in a cool and dry place to prevent hydrolysis due to excessive humidity. If the temperature is too high, it may cause its chemical reaction and cause quality variation. The warehouse should be well ventilated and protected from direct sunlight to cover the energy of sunlight or promote its decomposition.
Furthermore, its packaging must be tight. Suitable packaging materials must be used to prevent leakage. Because it may be harmful to the human body and the environment, if it leaks, it will be very difficult to deal with. Packaging materials should be corrosion-resistant and pressure-resistant to ensure that they are not damaged during transportation.
During transportation, caution should also be taken. Do not mix with oxidizing, acidic, and alkaline substances. Contact with these substances may cause severe reactions and endanger transportation safety. Transportation tools should be clean, dry, and have leak-proof, fire-proof and other facilities.
When handling, operators must wear appropriate protective equipment, such as protective clothing, gloves, goggles, etc., to prevent contact injuries. Handle with care during loading and unloading to avoid damage to the package due to impact.
In summary, the storage and transportation of butane-1,4-dimethyl sulfonate, from environmental control, packaging requirements, to transportation specifications, and personnel protection, all need to be carefully considered to ensure its safety and quality.
4. What are the possible safety risks when using Butane-1,4-Diyl Dimethanesulfonate?
Butane - 1,4 - Diyl Dimethanesulfonate, which is 1,4-butanediol dimethylsulfonate, may pose many safety risks when used.
It is toxic and can endanger health if not carefully entered into the body, through mouth, inhalation or skin contact. If ingested orally, it may cause gastrointestinal discomfort, such as nausea, vomiting, abdominal pain, and even damage to internal organs; inhalation of its dust or volatile gases can irritate the respiratory tract, cause cough, asthma, long-term exposure or increase the risk of lung diseases; skin contact may cause allergies, redness, swelling, itching and other symptoms.
Furthermore, the substance is irritating. On the eyes, it can cause severe irritation, causing pain, tears, blurred vision, improper handling or permanent eye damage; in contact with the skin, it can also irritate the skin and cause skin inflammation.
At the same time, it may be persistent and bioaccumulative in the environment. If released into the environment, it is difficult to degrade, and it will remain in the soil and water, passing and accumulating through the food chain, posing a threat to the ecosystem and biodiversity.
In addition, its chemical properties are active, and it may react violently when exposed to specific substances, such as strong oxidants, strong alkalis, etc., which may cause fires and explosions. When storing and using, if the operation is not standardized, such as not isolating the fire source, heat source, or storing in an improper environment, the temperature and humidity are out of control, it may trigger danger.
Therefore, when using Butane-1,4-Diyl Dimethanesulfonate, it is necessary to strictly follow the safety operating procedures and take protective measures to prevent harm to the human body and the environment.
5. What are the relevant synthesis methods of Butane-1,4-Diyl Dimethanesulfonate?
Butane - 1,4 - Diyl Dimethanesulfonate is 1,4-butanediol dimethylsulfonate. The relevant synthesis methods are as follows:
To prepare 1,4-butanediol dimethylsulfonate, 1,4-butanediol is often used as the starting material. In one method, 1,4-butanediol is reacted with p-toluenesulfonyl chloride in the presence of a suitable base such as pyridine. In this reaction, pyridine can neutralize the hydrogen chloride generated by the reaction, so that the reaction proceeds in the direction of generating p-toluenesulfonate. The hydroxyl group of 1,4-butanediol reacts with the sulfonyl chloride of p-toluenesulfonyl chloride to obtain 1,4-bis (p-toluenesulfonyloxy) butane. Then, the product is reacted with sodium methanesulfonate in a suitable solvent, such as N, N-dimethylformamide (DMF). The methanesulfonate ion attacks the carbon-oxygen bond of the p-toluenesulfonate, and a nucleophilic substitution reaction occurs. The p-toluenesulfonate leaves, and then 1,4-butanediol dimethanesulfonate is obtained.
There is another way to make 1,4-butanediol react directly with methanesulfonyl chloride. This reaction also requires the participation of a base, such as triethylamine. Triethylamine can capture the hydrogen chloride generated by the reaction and promote the reaction. The sulfonyl chloride of methanesulfonyl chloride reacts with the hydroxyl group of 1,4-butanediol to directly form 1,4-butanediol dimethanesulfonate. During the reaction, it is necessary to pay attention to the reaction temperature, the proportion of reactants and the reaction time. If the temperature is too high, side reactions may occur; if the proportion of reactants is improper, the yield may be reduced. Control the appropriate reaction conditions to obtain a higher yield of 1,4-butanediol dimethanesulfonate.