What is the chemical structure of Cis- [2- (2,4-Dichlorophenyl) -2- (1H-Imidazol-1-Ylmethyl) -1,3-Dioxolan-4-Yl] Methyl-4-Methylbenzenesulphonate
Eh! This is the name of the chemical, which consists of Cis - [2- (2,4-dichlorophenyl) -2 - (1H-imidazole-1-ylmethyl) -1,3-dioxypentyl-4-yl] methyl-4-methylbenzenesulfonate. To explain its chemical identity, this is the name of the disassembly.
First "2- (2,4-dichlorophenyl) ", this is a benzene, and is replaced by a chlorine atom at the 2,4 positions. "2- (1H-imidazole-1-ylmethyl) ", the nitrogen atom of 1H-imidazole is located in the methyl group, and this methyl group is located in the main group. "1,3-dioxolane-4-group", containing a five-membered oxygen atom, and is mainly located in the fourth position.
In addition, "methyl-4-methylbenzenesulfonate", that is, methyl is located in the sulfonic acid group of 4-methylbenzenesulfonate. Therefore, this compound is composed of dichlorophenyl, imidazolyl methyl, dioxolane and methylbenzenesulfonate. Its empty form (Cis), which indicates the position of the phase group in the empty phase. The chemical properties of this compound, the parts of which are intersected in a specific way, exhibit special properties.
What are the physical properties of Cis- [2- (2,4-Dichlorophenyl) -2- (1H-Imidazol-1-Ylmethyl) -1,3-Dioxolan-4-Yl] Methyl-4-Methylbenzenesulphonate
Cis - [2- (2,4-dichlorophenyl) -2 - (1H-imidazole-1-ylmethyl) -1,3-dioxolane-4-yl] methyl-4-methylbenzenesulfonate The physical properties of this compound are particularly important, which is related to its performance in various applications.
Looking at its properties, under normal circumstances, it is mostly white to white crystalline powder, which is conducive to observation and preliminary identification. Its melting point is also a key physical property, about [X] ° C. The exact value of the melting point can provide the basis for the purity identification and thermal stability of the substance. In terms of solubility, it exhibits a certain solubility in organic solvents such as ethanol and acetone, but its solubility in water is relatively limited. This difference in solubility is of great significance in the preparation of preparations and the construction of reaction systems.
In addition, its density is also an important parameter, about [X] g/cm ³. The determination of density helps to accurately control the relationship between material volume and quality in actual production and application. In terms of stability, it can be maintained in a dry environment at room temperature. In case of high temperature, high humidity or strong light exposure, it may decompose. This characteristic also needs to be paid attention to in detail during storage and use.
What is the use of Cis- [2- (2,4-Dichlorophenyl) -2- (1H-Imidazol-1-Ylmethyl) -1,3-Dioxolan-4-Yl] Methyl-4-Methylbenzenesulphonate
Cis- [2 - (2,4 - dichlorophenyl) - 2 - (1H - imidazole - 1 - ylmethyl) - 1,3 - dioxolane - 4 - yl] methyl - 4 - methylbenzenesulfonate, which is a key intermediate in the field of pharmaceutical chemistry, plays an indispensable role in the creation of antifungal drugs.
The research and development process of Guanfu antifungal drugs, many successful varieties rely on this intermediate to build their core structure. In the synthesis route, with its unique chemical structure, it can react ingeniously with many reagents to derive compounds with excellent antifungal activity.
Investigate its mechanism of action, including that its structure can precisely fit specific targets in fungi, or interfere with the biosynthesis of fungal cell membranes, or hinder its key metabolic pathways, thereby effectively inhibiting the growth and reproduction of fungi. For example, in the synthesis of azole antifungal drugs, this intermediate participates in key steps, and through a series of carefully designed reactions, the active entity of the drug is finally created. By skillfully regulating the reaction conditions and steps, the purity and yield of the target drug can be greatly improved, laying a solid material foundation for the clinical treatment of fungal infectious diseases. Therefore, cis - [2 - (2,4 - dichlorophenyl) - 2 - (1H - imidazole - 1 - ylmethyl) - 1,3 - dioxolane - 4 - yl] methyl - 4 - methylbenzenesulfonate plays a pivotal role in the field of pharmaceutical research and development.
What is the synthesis method of Cis- [2- (2,4-Dichlorophenyl) -2- (1H-Imidazol-1-Ylmethyl) -1,3-Dioxolan-4-Yl] Methyl-4-Methylbenzenesulphonate
To obtain cis- [2- (2,4-dichlorophenyl) -2- (1H-imidazole-1-ylmethyl) -1,3-dioxolane-4-yl] methyl-4-methylbenzenesulfonate, specific steps and processes need to be followed.
First, 2,4-dichlorobenzaldehyde and a specific diol compound are taken under suitable catalyst and reaction conditions. This reaction requires fine regulation of temperature, pH and reaction time to ensure high yield and purity of acetal products. After the acetalization is completed, the product is separated and purified to obtain a pure 2- (2,4-dichlorophenyl) -1,3-dioxyamyl intermediate.
This intermediate is reacted with 1H-imidazole-1-based methylation reagent in a base-catalyzed environment. The strength and amount of base, as well as the choice of reaction solvent, have a great influence on the reaction process and product configuration. The reaction process needs to be closely monitored so that methylation occurs precisely at the predetermined position, and 2- (2,4-dichlorophenyl) -2- (1H-imidazole-1-ylmethyl) -1,3-dioxyamyl derivatives are obtained.
Then the 4-position hydroxyl group of the derivative is sulfonated. 4-methylbenzenesulfonyl chloride is used as a sulfonylation reagent and reacts in the presence of an organic base. During sulfonylation, the anhydrous degree of the reaction system, temperature control and the molar ratio of the reactants are all key factors. After this step, 4-methylbenzenesulfonate ester groups are successfully introduced.
Finally, by means of column chromatography and recrystallization, the reaction products were carefully purified to remove impurities and obtain high-purity cis- [2- (2,4-dichlorophenyl) -2- (1H-imidazole-1-ylmethyl) -1,3-dioxyamyl-4-yl] methyl-4-methylbenzenesulfonate. Throughout the synthesis process, the control of the conditions of each step of the reaction and the purification of the product are of paramount importance, which is related to the quality and yield of the target product.
Cis- [2- (2,4-Dichlorophenyl) -2- (1H-Imidazol-1-Ylmethyl) -1,3-Dioxolan-4-Yl] Methyl-4-Methylbenzenesulphonate
Cis- [2 - (2,4 - dichlorophenyl) - 2 - (1H - imidazole - 1 - ylmethyl) - 1,3 - dioxolane - 4 - yl] methyl - 4 - methylbenzenesulfonate is an organic compound. I shall inform you in detail about the safety precautions of this substance.
First, this substance may be toxic. If inadvertently touched, it can cause irritation, redness, swelling, and itching on the skin; in the eyes, it can cause tingling, tears, and blurred vision. If inhaled, or cause respiratory irritation, such as coughing, asthma, and even damage to the lungs. If taken by mistake, or hurt the stomach, causing nausea, vomiting, abdominal pain. Therefore, be careful when handling this thing.
Second, this thing is flammable. In case of open flame or hot topic, there is a risk of explosion. When storing, keep away from fire and heat sources, place in a cool and ventilated place, and store it separately from oxidants and acids. Do not store it in combination.
Third, this thing may be harmful to the environment. Do not discard it in the environment at will to avoid polluting soil and water sources. Dispose of this waste in accordance with relevant environmental regulations.
Fourth, when handling this thing, you must wear appropriate protective equipment. If you wear protective gloves, you can prevent skin contact; wear goggles to protect your eyes; wear a gas mask to avoid inhalation. And the operation room needs to be well ventilated to reduce the concentration of this substance in the air.
Anyone who handles cis - [2 - (2,4 - dichlorophenyl) - 2 - (1H - imidazole - 1 - ylmethyl) - 1,3 - dioxolane - 4 - yl] methyl - 4 - methylbenzenesulfonate should pay attention to the above safety matters to ensure their own safety and the environment.