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What Colistinemethanesulfonate Sodique for?
Colistinemethanesulfonate Sodique, that is, colistin mesylate sodium, its applicable population is as follows:
This drug is mostly suitable for severe patients with Gram-negative bacteria infections. Because Gram-negative bacteria can often cause serious infections, such as pneumonia, sepsis, urinary tract infections, etc., which can wreak havoc in patients and endanger their lives. Colistin mesylate sodium has significant inhibitory and killing power on such bacteria.
People with low immunity, such as those who use immunosuppressants for a long time, AIDS patients, and patients with malignant tumors, etc., are vulnerable to Gram-negative bacteria due to their weak defense capabilities. At this time, colistin mesylate sodium can be a powerful weapon against bacteria.
There are also patients who are resistant to other commonly used antimicrobial drugs. When the infection has not been cured after a variety of antimicrobial treatments, it has been confirmed by testing that it is resistant to commonly used drugs, and the pathogen is sensitive to colistin sodium mesylate, this drug becomes a key choice for treatment, bringing hope for the patient's recovery.
However, it should be noted that children, pregnant women and breastfeeding women should be extra cautious when using drugs. Children's organs are delicate and their bodies are not fully developed. The dosage and safety of the drug need to be carefully considered; pregnant women's medication is related to the safety of the fetus, and there is a slight carelessness or adverse effects; breastfeeding women use drugs, drugs or pass them to the baby through milk, so they need to weigh the pros and cons, and can only be used under the strict guidance of a doctor.
Colistinemethanesulfonate common side effects of Sodique
Colistinemethanesulfonate Sodique is a medicine commonly used by physicians. However, it has all kinds of common side effects, which cannot be ignored.
One is related to the kidney, and there is a risk of damage. The kidney is responsible for the metabolism of water, the storage of essence and qi, and this drug may cause abnormal renal function. In light cases, protein may be seen in the urine, which is a sign of subtle leakage of the kidney; in severe cases, it may cause oliguria or anuria, and the kidney is open and closed. Because the drug poison damages the veins of the kidney, it affects its ability to distinguish turbid secretion and makes the metabolism of water abnormal.
Second, it also affects the ear. The ear is the external aperture of the kidney, and the kidney is connected to the auricular. The toxicity of the drug is committed in the ear along the meridian, which can cause tinnitus and hearing loss. For those with tinnitus, the buzzing sound in the ear is often heard, which disturbs people's purity; for those with hearing loss, it gradually becomes insensitive to hearing and hearing, and the human speech response gradually feels laborious. This is all because the drug poison hurts the meridians of the ear, causing the auricular to lose nourishment and gradually lose its function.
Third, it also has an effect on the neuromuscular junction. Or cause muscle weakness and limb weakness. The movement of the human body depends on the coordination and cooperation of the neuromusculature. This drug interferes with its transmission, and the muscles lose their normal innervation of the nerves, so it looks like fatigue. When moving, the steps are heavy, and it is difficult to lift the arms and legs. In severe cases, it may cause the movement to be unable to take care of itself,
Fourth, it can cause discomfort in the gastrointestinal tract. The spleen and stomach are the foundation of the day after tomorrow, and the main transportation and transformation of water and valley. When this medicine enters the body, it is easy to hurt the qi of the spleen and stomach, causing nausea, vomiting, diarrhea and other diseases. If you have nausea, the epigastric area is uncomfortable, and the feeling of wanting to vomit occurs frequently; if you vomit, the things in the stomach will come out in reverse; if you have diarrhea, the water and valley will not melt, and it will be clear and turbid, and the large intestine will be injected. The transportation and transformation of the spleen and stomach are abnormal, and the biochemistry of qi and blood will be passive. After a long time, the body will become thinner and the righteousness will be weak.
When a doctor uses this medicine, he should
What is the usage and dosage of Colistinemethanesulfonate Sodique?
The usage and dosage of kolimycin sodium mesylate are related to the therapeutic effect and cannot be ignored. This medicine is mostly used for intravenous infusion or intramuscular injection.
When intravenous infusion, it needs to be injected slowly. As for the dosage, it varies according to the patient's age, weight, and the severity of the disease. For adults, the general daily dosage is about 3-5 milligrams per kilogram of body weight, usually given in 2-3 installments. If the disease is severe, the dose may be increased as appropriate, but it must be done with caution to prevent unexpected side effects.
When injecting intramuscularly, certain procedures should also be followed. The dosage is roughly similar to that of intravenous infusion, but the injection site should be selected where the muscles are rich, and attention should be paid to rotation to avoid local discomfort. The dosage of children needs to be accurately weighed, and it is usually carefully calculated according to their weight to ensure that the medication is safe and effective. Cover the viscera of children is delicate, and the tolerance to drugs is different from that of adults. If the medication is slightly worse, it may cause thousands of miles of loss. Therefore, when taking medication, the doctor must carefully review the condition, calculate the dose, closely observe the patient's response, and adjust it in a timely manner to achieve the purpose of treating the disease and protecting the body.
Colistinemethanesulfonate What are the precautions in the use of Sodique?
When using Colistinemethanesulfonate Sodique, there are several things to pay attention to.
First of all, the dosage system must be determined according to the patient's condition, age, weight and renal function. Children, the elderly and those with poor renal function should pay special attention to the dosage to prevent the harm of drug accumulation. When taking medication, when taking the doctor's advice, do not increase or decrease the dose, so as not to achieve the effect of the drug or cause adverse reactions.
For times, the patient's reaction should be closely monitored between medications. Common adverse reactions, or signs of kidney damage, such as changes in urine color, urine volume, and abnormal blood creatinine, urea nitrogen; or neurotoxicity, such as dizziness, fatigue, paresthesia, etc. If you see such reactions, when the doctor, according to the situation, or adjust the dose, or stop taking the drug.
In addition, when this drug is used in combination with other drugs, it is necessary to be warned of interaction. If used with nephrotoxic or neurotoxic drugs, its toxic and side effects may increase. Therefore, when seeking medical treatment, it is necessary to inform all the drugs used in detail, so that the doctor can review the drug interaction and ensure the safety of the drug.
In addition, the route of medication is also important. When injecting, medical care should follow aseptic procedures to prevent infection, and pay attention to whether there are local reactions such as redness, swelling, and pain at the injection site.
In short, when using sodium creamaxian sulfonate, the correct dosage, the observation of reaction, the prevention of drug interaction, and the careful route of medication are all essential to ensure the safety and effectiveness of medication.
Colistinemethanesulfonate Sodique interact with other drugs?
colistinemethanesulfonate sodique, that is, polymyxin E sodium methanesulfonate. It may interact with other drugs during clinical use.
To observe the properties of the drug, polymyxin E sodium methanesulfonate has unique antibacterial properties, but it also has its characteristics. It is equivalent to nephrotoxic drugs such as aminoglycosides and vancomycin, which may exacerbate nephrotoxicity. These drugs have potential damage to the kidneys, and the combination of the two is like adding insult to the snow, causing the burden of the kidney to increase, and easily triggering abnormal renal function.
Furthermore, when used in combination with neuromuscular blockers, caution is also required. The meeting of the two may enhance the blocking effect of neuromuscular, or even cause a crisis of respiratory depression. This is because both of them have an impact on neuromuscular transmission, and if used together, the effect will be superimposed, endangering life.
If used in combination with ototoxic drugs, such as some quinolones, although the risk of increased ototoxicity is slightly less than that of nephrotoxicity, it is also inevitable. Because they can damage the structure and function of the inner ear, when used together, it may increase tinnitus, hearing loss and other diseases.
Therefore, when a doctor uses drugs, he must carefully examine the patient's condition, carefully observe the interaction of all drugs used, and carefully weigh the advantages and disadvantages, and then use them properly to ensure the well-being of patients and avoid the risk of drug harm.