What is the chemical structure of D (+) -3-Bromo Camphor-8-Sulfonic Acid (Ammonium Salt)?
The chemical structure of D- (+) -3-bromo camphor-8-sulfonic acid (ammonium salt) is an interesting topic in the field of organic chemistry. The structure of this compound is derived from the basic skeleton of camphor.
Camphor, originally a terpenoid compound, has the skeleton of dicyclic [2.2.1] heptane. On this basis, bromine atoms are introduced at the 3rd position, and the introduction of bromine atoms greatly affects the chemical and physical properties of the compound. Bromine atoms have strong electronegativity, which can change the polarity of molecules, which in turn affects their solubility and reactivity.
And the 8-position is connected to the sulfonic acid group, and the sulfonic acid group (-SO-H) is a strong acidic group, giving the compound good water solubility. The sulfonic acid group is combined with ammonium ions (NH < unk >) to form an ammonium salt. The formation of ammonium salts enhances the stability and solubility of the compound in water. The nitrogen atom in the ammonium ion is covalently connected with the four hydrogen atoms, and the whole is positively charged. It is electrostatically attracted to the negatively charged sulfonate ion to form a stable salt structure.
In the structure of this compound, the spatial arrangement of each atom and group is also very critical. The three-dimensional structure of the camphor skeleton makes the bromine atom and the sulfonic acid group have a specific orientation in space. This three-dimensional chemical feature has far-reaching impact on its application in asymmetric synthesis and other fields. Overall, the unique chemical structure of D- (+) -3-bromocamphor-8-sulfonic acid (ammonium salt) makes it show potential application value in many fields such as organic synthesis and chiral recognition.
What are the main uses of D (+) -3-Bromo Camphor-8-Sulfonic Acid (Ammonium Salt)
D (+) -3-bromocamphor-8-sulfonic acid (ammonium salt) has a wide range of uses. In the field of organic synthesis, it is often used as a chiral aid. Due to its unique structure and chiral characteristics, the cap can induce the reaction to selectively generate products of specific configurations. For example, in asymmetric synthesis reactions, it can guide the reaction in a specific chiral direction to obtain products with high optical purity, which is of great significance in drug synthesis.
During the development of drugs, many active pharmaceutical ingredients require specific chiral configurations to have ideal efficacy. D (+) -3-bromocamphor-8-sulfonic acid (ammonium salt), through its chiral induction, helps to synthesize drug intermediates with precise chiral structures, thereby improving the efficiency and quality of drug development.
Furthermore, in the field of analytical chemistry, it can be used as a chiral resolution agent. For racemate mixtures, the separation and purification of enantiomers can be achieved according to the difference in their binding ability with different enantiomers, which can help researchers accurately obtain compounds with a single chiral configuration in order to further explore their properties and functions.
In addition, in the field of materials science, it may participate in the preparation of chiral materials. Chiral materials exhibit unique properties in optics, electricity, and catalysis. As a key raw material for the construction of chiral structures, D (+) -3-bromocamphor-8-sulfonic acid (ammonium salt) provides possibilities for the creation of new chiral materials, expanding the research boundaries and application scenarios of materials science.
What is the preparation method of D (+) -3-Bromo Camphor-8-Sulfonic Acid (Ammonium Salt)?
The method of preparing D- (+) -3-bromo camphor-8-sulfonate ammonium salt is quite complicated and requires multiple and delicate steps.
First, camphor is taken as the base, and a specific brominating agent is used to precisely bromide it in a suitable reaction environment to obtain 3-bromo camphor. This step requires careful control of the reaction conditions, such as temperature and brominating agent dosage, to prevent impurities from being generated due to excessive bromination.
Second, 3-bromo camphor is treated with a strong sulfonating agent, so that the sulfonic acid group is ingeniously introduced into 8 positions to obtain 3-bromo camphor-8-sulfonic acid. This step also requires detailed observation of the reaction process to avoid side reactions.
To obtain 3-bromo camphor-8-sulfonic acid, then react with ammonia or ammonium salt, carefully adjust the pH value and reaction time, and finally obtain pure D- (+) -3-bromo camphor-8-sulfonic acid ammonium salt. This product may be purified by recrystallization, column chromatography, etc., to remove impurities and keep purity to achieve high purity requirements. Every step is related to the quality and yield of the product, and careful handling is required to achieve this delicate preparation.
D (+) -3-Bromo Camphor-8-Sulfonic Acid (Ammonium Salt) What are the precautions when storing and transporting?
D (+) -3-bromo camphor-8-sulfonate ammonium salt, during storage and transportation, need to pay attention to many matters. This compound is extremely sensitive to temperature and humidity, and high temperature can easily cause it to decompose and deteriorate, so it should be stored in a cool and dry place, usually 2-8 ° C. If the humidity is too high, it may absorb moisture and agglomerate, which will affect the quality.
In addition, this material has a certain chemical activity and should be kept away from strong oxidants, strong bases and other substances to prevent chemical reactions and damage its chemical properties. When transporting, it is also necessary to ensure that the packaging is intact to avoid vibration and collision, so as to prevent product leakage due to package rupture.
In addition, because of its possible irritation, storage and transportation sites should be well ventilated to prevent operators from inhaling harmful gases. When working, staff should also wear appropriate protective equipment, such as gloves, masks, goggles, etc., for safety. In short, careful treatment of storage and transportation can ensure the quality and safety of D (+) -3-bromocamphor-8-sulfonate.
What is the market price of D (+) -3-Bromo Camphor-8-Sulfonic Acid (Ammonium Salt)?
D (+) -3 -bromocamphor-8 -sulfonic acid (ammonium salt), the price of this product in the market is difficult to determine. The price often varies due to various reasons.
First, the distance of the production place has a great impact. If the production place is close to the city and the freight is saved, the price may be slightly lower; if the production place is far away, the freight will be added, and the price will increase.
Second, the quality is also the key. Those with good quality are finely prepared, those with less variety, and the use is wide, and their price is high; those with poor quality, or more heterogeneity, are limited in use, and the price is low.
Third, the supply and demand of the city determines the price. If there are many applicants, there are few suppliers. In order to obtain it, people compete for bids, and the price must be increased; if the supply exceeds the demand, the business will sell it, or the price will be reduced.
Looking at "Tiangong Kaiwu", he said that the production system of all things, although he did not specify the price of this thing, it is the same. Push other things, D (+) -3 -bromocamphor-8 -sulfonic acid (ammonium salt) in the market, the price may be between tens of gold and hundreds of gold per kilogram, but this is only a rough number. The actual price still needs to be carefully observed by the market, and those who consult the merchants can obtain a definite number.