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What are the common side effects of doxazosin methanesulfonate?
Doxazosin hydrochloride is a common drug, and its common auxiliary effects are as follows:
First, in the treatment of hypertension, doxazosin hydrochloride can relax the smooth muscle of blood vessels and reduce the resistance of peripheral blood vessels. This is its effect of assisting in lowering blood pressure. It can reduce blood pressure smoothly, and when lowering blood pressure, it rarely affects the heart rate. It can effectively reduce the risk of cardiovascular and cerebrovascular diseases caused by high blood pressure, such as reducing the incidence of serious diseases such as cerebral hemorrhage and myocardial infarction caused by hypertension.
Second, for benign prostatic hyperplasia, this drug can selectively block the alpha 1 receptor in the prostate and bladder neck, relax the smooth muscle in this part, and improve the obstruction of the bladder outlet. In this way, the symptoms of patients with difficulty urinating can be relieved, and symptoms such as frequent urination, urgency, insufficiency, and laborious urination can be improved, greatly improving the quality of life of patients.
Third, in the cardiovascular system, doxazosin hydrochloride has a certain beneficial effect on blood lipid metabolism. It can moderately increase the level of high-density lipoprotein cholesterol, reduce the level of triglycerides, and regulate blood lipids to a certain extent, which in turn protects the cardiovascular system and reduces the risk of atherosclerosis. It can optimize the endovascular environment and make blood vessels more elastic and unobstructed.
Fourth, from the perspective of tolerance, doxazosin hydrochloride is usually well tolerated. Compared with some other antihypertensive drugs, the probability of adverse reactions such as dry cough and orthostatic hypotension is relatively low, and the patient's compliance with medication is better, which is more conducive to long-term regular medication to maintain blood pressure stability and control of prostatic hyperplasia symptoms. This characteristic makes it less likely for patients to interrupt treatment due to adverse reactions during treatment, ensuring the continuity and effectiveness of treatment.
What are the applicable populations of doxazosin methanesulfonate?
For doxazosin hydrochloride, the applicable groups are as follows:
In patients with kidney-yang deficiency and phlegm-blood stasis, this medicine may be available. If men have insufficient kidney-yang, resulting in bladder gasification loss, unfavorable urination, and also see phlegm and blood stasis blocking meridians, limb sleepiness, local pain, etc., doxazosin hydrochloride can help regulate.
In addition, people with damp-heat accumulation under the focus can also be considered for application if they see frequent urination, acute urinary pain, yellow-red urine color, and long-term accumulation of damp-heat, hindering the operation of qi and blood, and local swelling discomfort. However, for such people, the doctor needs to carefully review their physique and symptoms, and weigh the pros and cons before taking the drug.
There are also those who have poor mood, liver depression and qi stagnation, then qi stagnation and blood stasis, and endogenous phlegm and dampness. If they have symptoms such as poor urination and abdominal fullness, this medicine may also be helpful. Gaidoxazosin hydrochloride can raise the solar term machine to a certain extent, dissipate blood stasis, reduce phlegm and remove dampness, and solve the disease.
When taking medicine, be careful. The function of the viscera of the elderly and infirm is gradually declining. The dosage of the medicine needs to be carefully considered, and beware of drug injury. Children's viscera are delicate and the form is not full. If it is not a last resort, it is not appropriate to use this medicine lightly. Pregnant women and breastfeeding women, related to the fetal essence and the safety of the baby, need to be more cautious. If it is not absolutely necessary and fully evaluated by a professional doctor, they must not take it by themselves to avoid endless harm. And during the medication process, it is necessary to closely observe the physical reaction. If there is any discomfort, immediately stop the medication and seek medical treatment.
What is the usage and dosage of doxazosin methanesulfonate?
The method and dosage of doxazosin methanesulfonate are quite important, and are related to the efficacy and health of the treatment of diseases. "Tiangong Kaiwu" does not describe this substance in detail, but the method of medical pharmacology can show its approximation.
Doxazosin methanesulfonate is often used as a medicine for the treatment of hypertension and benign prostate hyperplasia. It is used in hypertension to lower blood pressure and make blood vessels calm. The dosage should be light at the beginning to prevent discomfort caused by over-lowering. It is often started with 1mg once a day, and then gradually increases or decreases depending on the patient's blood pressure and tolerance. If the patient is well tolerated and the blood pressure is not ideal, the dose of 1mg can be increased every two to four weeks, but the final dose is generally not more than 16mg per day.
When used for benign prostatic hyperplasia, it is intended to relieve the obstruction of the urinary tract and make the urine clear. The starting dose is also 1mg per day, and then it can be increased every two to four weeks according to the improvement of the patient's symptoms and tolerance. The usual effective dose is 4mg per day.
When taking the medication, the doctor must carefully observe the patient's condition, consider the age of the teeth, body qi, and the presence or absence of other diseases. The elderly gradually decline in qi and blood, the function of the viscera is weakened, and the dosage of medication should be light; the young and healthy, tolerate or strong, can be in accordance with the conventional dose, but also need to be cautious. And between medications, pay attention to the patient's reaction, such as whether there is dizziness, fatigue, palpitations and other diseases, if there is discomfort, quickly adjust, or reduce the dosage, or make it easier for other drugs, so that patients can benefit and do less harm. The way of medication is not static, and you must use dialectical methods. Your mileage may vary in order to protect your health as much as possible.
What to pay attention to during the use of doxazosin methanesulfonate
During the use of doxazosin extended-release tablets, the following matters should be noted:
First, when taking the initial medication and adjusting the dose, beware of orthostatic hypotension. This is because doxazosin can cause vasodilation. When standing or getting up too fast, the blood pressure drops sharply, which is easy to cause dizziness, dizziness, and even fainting. Therefore, the change of position must be slow. When standing up from the lying position or sitting position, pause for a while, and then move after the body adapts.
Second, pay close attention to the changes in blood pressure. During the medication period, blood pressure should be measured regularly, according to blood pressure fluctuations, and the drug dose should be adjusted in a timely manner according to the doctor's instructions. If the blood pressure is too low, or dizziness, fatigue and other discomforts occur, immediate medical attention is required.
Third, pay attention to the effect on liver function. Although it is rare for this drug to cause abnormal liver function, it should not be taken lightly. Liver function should be checked regularly according to the doctor's instructions. If there is any weakness, loss of appetite, jaundice and other abnormalities, the doctor should be informed immediately.
Fourth, pay attention to drug interactions. Doxazosin can interact with many drugs, such as cimetidine and ketoconazole. Combined use can increase the blood concentration of doxazosin and increase the risk of adverse reactions. When seeking medical treatment, you need to inform the doctor of all the drugs you are taking, including prescription drugs, over-the-counter drugs, health products, etc., to prevent adverse interactions.
Fifth, be vigilant for adverse reactions. In addition to orthostatic hypotension, it can also cause drowsiness, fatigue, nausea, vomiting, etc. If the adverse reactions are serious or continue to not relieve, medical attention should be sought in time.
Sixth, special groups need to be cautious when using drugs. Elderly patients are more susceptible to adverse reactions such as hypotension due to functional decline of the body, and need close monitoring; Pregnant women and breastfeeding women, due to unknown effects on the fetus or infant, should not be used unless necessary; Children's drug safety and effectiveness have not been established, so it should not be used.
During the medication period, you need to pay more attention to your own condition. If there is any abnormality, you should communicate with the doctor to plan safe and effective medication.
Does doxazosin methanesulfonate interact with other drugs?
Doxazosin methanesulfonate may interact with other drugs. Due to the nature of drugs, each has its own differences, and it is used in combination, or there are variables.
Doxazosin methanesulfonate is classified as an alpha-blocker, often used to lower blood pressure and treat prostate hyperplasia. If used with other blood pressure-lowering drugs, such as calcium channel blockers, angiotensin-converting enzyme inhibitors, etc., it may cause a sudden drop in blood pressure, dizziness, fatigue, and even convulsion. Because of the synergy of all drugs, the power of lowering blood pressure is too great, the qi and blood go down too much, and the yang does not rise.
And when this drug is used in combination with cimetidine, it should also be noted. Cimetidine can cause an increase in the blood concentration of doxazosin, which affects the metabolism of doxazosin. If the blood concentration is high, the efficacy of the drug is enhanced, and the risk of adverse reactions is also increased, such as palpitations, headaches, etc., or more likely to occur.
If taken with grapefruit juice, there are also hidden dangers. Grapefruit juice contains ingredients that can inhibit the enzymes involved in the metabolism of doxazosin in the intestines, resulting in increased absorption, slower metabolism, and increased blood concentration, thereby increasing the chance of adverse reactions.
As for anticoagulants, such as warfarin, etc., used with doxazosin methanesulfonate, although there is no conclusive evidence that there is a significant interaction between the two, clinical caution is still required. Because cardiovascular patients often need to use such drugs in combination, if there is any carelessness, it may cause abnormal changes in coagulation function.
Doctors who use drugs must carefully review the drugs taken by patients, distinguish their nature, measure their advantages and disadvantages, and weigh them. Make sure that the drugs are effective and avoid harm, and ensure the well-being of patients.
