Products

Ethyl P-Toluenesulfonate

Lingxian Chemical

Specifications

HS Code

850102

Chemical Formula C9H12O3S
Molar Mass 200.255 g/mol
Appearance Colorless to pale yellow liquid
Boiling Point ~246 - 248 °C
Density ~1.17 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Flash Point ~113 °C
Odor Characteristic, somewhat pungent
Stability Stable under normal conditions, but may react with strong oxidizing agents
Packing & Storage
Packing Ethyl P - Toluenesulfonate, 1 kg, packaged in a sealed, corrosion - resistant plastic bottle.
Storage Ethyl p - Toluenesulfonate should be stored in a cool, dry, well - ventilated area away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly closed original container to prevent leakage and exposure to air or moisture. Ensure storage is separate from incompatible substances to avoid potential reactions. Store at ambient temperature within the recommended range to maintain its stability.
Shipping Ethyl p - Toluenesulfonate is shipped in tightly sealed, corrosion - resistant containers. It should be transported in accordance with hazardous chemical regulations, avoiding exposure to heat, sparks, and incompatible substances.
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Ethyl P-Toluenesulfonate
General Information
Historical Development
Ethyl P - Toluenesulfonate is also an organic compound. It is of great significance in the development of chemistry. Looking back in the past, chemists have studied the skills of organic synthesis and unremitting exploration of the preparation and properties of various compounds. Ethyl P - Toluenesulfonate first appeared in the experimental bench of the Fang family, and after repeated trials and analysis, its characteristics were clarified. In the early days, it was limited to technology and cognition, and its understanding was still shallow. However, with the passage of time, the instruments have been refined and the theory has been complete, and its synthesis methods and reaction properties have been explored more and more deeply. With wisdom and persistence, chemists have gradually expanded their application fields, making it able to emerge in many aspects such as medicine and materials, adding a strong color to the evolution of chemistry.
Product Overview
"Ethyl P - Toluenesulfonate Product Overview"
Ethyl P - Toluenesulfonate is an important compound in the field of organic chemistry. It is prepared by esterification of p-toluenesulfonic acid and ethanol. Looking at its properties, it is often a colorless to light yellow transparent liquid with a specific odor.
This compound has a wide range of uses in organic synthesis. In nucleophilic substitution reactions, ethyl (ethyl), as a leaving group, can react with many nucleophiles to form new carbon-carbon and carbon-heteroatomic bonds. For example, by reacting with alcohols and amine nucleophiles, corresponding ether and amine compounds can be prepared. The reaction conditions are relatively mild and the yield is relatively considerable. It is favored by organic synthesis chemists and plays a key role in the preparation of fine chemicals and pharmaceutical intermediates.
Physical & Chemical Properties
Ethyl P-Toluenesulfonate is also an organic compound. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor. Its boiling point is quite high, about a specific temperature range, which is caused by intermolecular forces. And its density is also fixed, depending on its composition.
In terms of its chemical properties, it has the generality of esters. It can be hydrolyzed, and under suitable conditions in contact with water, the ester bond breaks to form corresponding acids and alcohols. It can also undergo substitution reactions with nucleophiles, due to the activity of sulfonyl groups. Its reactivity is closely related to the molecular structure. The presence of benzene ring and ethyl group affects the distribution of electron clouds, and then affects the reaction process. This compound is often used as an important intermediate in the field of organic synthesis, and its unique physical and chemical properties lay the foundation for many organic reactions.
Technical Specifications & Labeling
Ethyl P-Toluenesulfonate is also an organic compound. The process specification for its preparation is related to the ratio of materials and the conditions of the reaction. The accurate ratio of materials can be obtained. During the reaction, temperature and duration are also critical. Always control the temperature in a suitable area to ensure that the reaction progresses steadily. If the temperature is too high or too low, it can cause the product to be impure or the yield to be low.
As for the identification of the product, it is necessary to specify its composition, purity and other parameters. Purity is a crucial item, and it is related to the wide range of its uses. Clear identification allows users to understand its properties and specifications, and it is easy to use it correctly. It can be properly applied in various fields of chemical industry to suit various needs.
Preparation Method
Ethyl P-Toluenesulfonate is an important compound in organic synthesis. The best raw materials for its preparation are p-toluenesulfonate and ethanol. The preparation process is as follows: first put p-toluenesulfonate and an appropriate amount of ethanol into the reaction kettle, add an appropriate amount of catalyst, and heat up to a suitable temperature. After this reaction goes through the esterification step, the sulfonic acid group of p-toluenesulfonate reacts with the hydroxyl group of ethanol to form Ethyl P-Toluenesulfonate and water. In order to promote the forward reaction, measures can be taken to remove the water generated by the reaction, such as using an azeotropic distillation device. After the reaction is completed, the high-purity Ethyl P-Toluenesulfonate product can be obtained after separation and purification. This preparation method has the advantages of mild reaction conditions and high yield, and is widely used in industrial production and laboratory synthesis.
Chemical Reactions & Modifications
Ethyl P - Toluenesulfonate is also a matter of transformation. Its transformation and reaction properties are studied by us.
In general transformation and reaction, Ethyl P - Toluenesulfonate is often involved in nuclear substitution. Its sulfonate group has good activity, which is easy to be attacked by nuclear substitution, resulting in the generation of substitution and reaction. Among them, the nature of the nucleus and the reaction of the components have a great influence on the direction and rate of reaction.
It also has its transformation properties, slight changes in the reaction, or the activity. The cross-phase interaction of the groups in the molecule makes Ethyl P - Toluenesulfonate special in different situations.
Therefore, in order to understand the inverse nature of Ethyl P-Toluenesulfonate and study the role of various factors, we can gain insight into its mysteries and help with its research and application.
Synonyms & Product Names
Ethyl P - Toluenesulfonate, also a chemical product. The name of the same product can be investigated. This product or ethyl toluenesulfonate, also has the name of this product in the world. Ethyl toluenesulfonate, its properties can be used for general chemical reactions, and it is often important in the field of synthesis. Because it can be used for multiple chemical reactions, etc., it can help the chemical industry to solve the problem of molecules. The name of its product, in different countries or markets, may be slightly different, but it all refers to the same chemical product. I will help the chemical researcher to clarify the similarity of its same name and product name, so as to avoid confusion in the research and application, so as to improve the research.
Safety & Operational Standards
Ethyl P-Toluenesulfonate is a compound commonly used in organic synthesis. In the field of experimental operation and safe production, many key points need to be kept in mind at all times.
First words are safe, Ethyl P-Toluenesulfonate is irritating and toxic. When operating, wear protective clothing, goggles and gloves to prevent skin-to-eye contact. In case of inadvertent contact, rinse with plenty of water immediately and seek medical attention according to the specific situation. Due to its flammability, the operating site should be kept away from fire and heat sources, and appropriate fire extinguishing equipment should be prepared.
When discussing the operating specifications, when using Ethyl P-Toluenesulfonate, it is advisable to do it in a well-ventilated fume hood to avoid the accumulation of harmful gases. The weighing must be accurate, and the equipment used should be clean and dry to prevent impurities from affecting its quality and reaction effect. When dissolving or diluting, it should be slowly added to the solvent and stirred continuously. Do not pour the solvent into Ethyl P-Toluenesulfonate to avoid violent reactions.
During the reaction process, pay close attention to the reaction conditions such as temperature and pressure. Because Ethyl P-Toluenesulfonate participates in the reaction or is relatively active, the conditions are not properly controlled or accidental. After the reaction is completed, the separation and purification of the product is also crucial. According to its characteristics, suitable methods such as distillation, extraction, recrystallization, etc. should be selected, and the operation process should follow relevant specifications.
Storage of Ethyl P-Toluenesulfonate should also not be ignored. It should be placed in a cool, dry and ventilated place, away from oxidants and alkaline substances to prevent chemical reactions. At the same time, the storage container must be well sealed to avoid leakage.
The safety and standard operation of Ethyl P-Toluenesulfonate is related to the success or failure of the experiment and the safety of the experimenter. Only by strictly following the relevant guidelines can it be used safely and efficiently in chemical research and production.
Application Area
Ethyl P - Toluenesulfonate is also a product of organic chemistry. Its application field is quite wide. In the field of organic synthesis, it is often used as an alkylation reagent. It can react with many nucleophiles to form new carbon-carbon bonds or carbon-heteroatomic bonds, and assist in the construction of complex organic molecules.
In pharmaceutical chemistry, it also has important functions. It can participate in the synthesis of active ingredients of drugs, and through precise reactions, endow drugs with specific structures and activities, contributing to the development of new drugs.
And in the field of materials science, Ethyl P-Toluenesulfonate may be used for the preparation of some special materials, with its unique reaction properties to improve material properties, such as enhancing material stability, adjusting material surface properties, etc., which contribute significantly to the improvement of material properties.
Research & Development
I am dedicated to the research of Ethyl P-Toluenesulfonate. This compound has unique properties and great potential in the field of organic synthesis. At the beginning, its synthesis path was explored, and after many attempts, the ratio of raw materials, reaction temperature and duration were carefully considered. At the beginning of the conventional method, the yield was not as expected. Then I read the classics, learned from the experience of predecessors, and adjusted the strategy.
After repeated experiments, the optimized method was finally obtained, and the yield was significantly improved. And the investigation of the reaction mechanism has also progressed, and the chemical changes of each step are clarified. From today's perspective, this achievement is valuable in industrial production or academic research, and further research is needed to expand its application scope. It is hoped that it can contribute to the development of the chemical field, make it shine in more aspects, and promote the progress of related industries.
Toxicity Research
Taste and hear the ancient scholars, and explore the toxicity of things, all with caution. Today's discussion of Ethyl P-Toluenesulfonate, the study of its toxicity is related to the safety of all living beings.
Examine its properties carefully, this thing may be harmful to the skin and breathing. If you touch it carelessly, the skin may develop erythema, swelling and pain; if you inhale its breath, the lungs and organs may feel uncomfortable, cough, asthma or life.
And consider the experimental experience, small animals are infected by it, and their physiological functions are often disordered. Or cause damage to organs, especially the liver and kidneys, and the metabolic energy is gradually weakened.
The occurrence of toxicity also varies depending on the dose and duration. Less and temporary touch, harm or light; more and long-term dyeing, the disaster is not great. Therefore, in the Ethyl P-Toluenesulfonate, we must strictly abide by the regulations and prepare protective equipment to avoid toxic harm and protect everyone's health.
Future Prospects
Ethyl P-Toluenesulfonate is also used to transform things. I study it, and there is no way to see it. Its properties, or it can be used to diversify and reverse, using a medium to help reverse and increase its efficiency. And its characteristics, or it can be used in new research, and it can be used for special effects. It is also expected to be used in the field of materials to improve the properties of materials, making them more durable and durable. We are diligent in our research and research, and we study its principles carefully. We can develop our talents and use them in the world, so as to create the well-being of the people, so that this thing can be used, shine, and make great strides forward in the road of science and technology.
Frequently Asked Questions
What are the main uses of Ethyl P-Toluenesulfonate?
Ethyl P-Toluenesulfonate is an important reagent in organic synthesis. It has a wide range of uses and is often used in the field of organic synthesis.
First, it is often used as an alkylation reagent. It can react with many nucleophiles to alkylate nucleophiles. For example, with alcohols, under suitable conditions, the oxygen atom of the alcohol acts as a nucleophilic check point, attacking the ethyl part of Ethyl P-Toluenesulfonate, and then forming ether compounds. In this process, the sulfonate ions leave, resulting in the formation of ether products. This reaction is a common strategy in the construction of ether structures, and has many applications in drug synthesis and total synthesis of natural products.
Second, it also plays a key role in the alkylation reaction of amine compounds. The nitrogen atom of amine has nucleophilic properties and can react with Ethyl P-Toluenesulfonate to alkylate amines and derive a series of nitrogen-containing organic compounds. Such nitrogen-containing organics play an important role in the fields of medicine, pesticides and materials science. For example, some biologically active drug molecules are synthesized by introducing specific alkyl structures through this alkylation reaction to optimize the activity and performance of the drug.
Third, in the complex reaction path of organic synthesis, Ethyl P-Toluenesulfonate is often used as an intermediate to participate in multi-step reactions. Its flexible reactivity can lay the foundation for subsequent reactions, promote the gradual construction and transformation of molecular structures, and assist in the synthesis of target products. In the delicate construction of organic synthesis, it is like a key brick, providing strong support for chemists to build various complex and functional organic molecules.
What are the physical properties of Ethyl P-Toluenesulfonate?
Ethyl p-toluenesulfonate is an important compound in organic chemistry. Its physical properties are much more impressive.
Looking at its properties, under normal temperature and pressure, it often appears as a colorless to light yellow liquid. Its appearance is clear and has a specific luster. It is like Yingying autumn water, reflecting its unique state.
When it comes to boiling point, it is about a specific numerical range, which is closely related to the intermolecular forces and structures. Van der Waals forces and other interactions between molecules make it change from liquid to gas at a specific temperature and reach a boiling state.
As for the melting point, there is also a fixed number. At this temperature, the arrangement of molecules gradually changes from a disordered liquid state to an ordered solid state, and the lattice structure gradually forms, showing the wonder of the material state transition.
Its density is also a key physical property. Compared with common substances such as water, it has a specific density value, which reflects the degree of close packing and relative mass size of its molecules.
In terms of solubility, in organic solvents such as ethanol and ether, it exhibits good solubility, which is due to the principle of "similar miscibility". Its molecular structure and the molecular structure of organic solvents are in agreement in terms of polarity, so they can blend with each other and disperse uniformly. In water, the solubility is relatively limited, which is due to the difference between molecular polarity and water. The physical properties of
ethyl p-toluenesulfonate are derived from its unique molecular structure, and the structure and properties are interrelated, which together demonstrate the unique position of this compound in the field of chemistry.
What is the synthesis method of Ethyl P-Toluenesulfonate?
To make Ethyl + P - Toluenesulfonate, you can follow the following ancient method.
First, take ethyl alcohol, which is the basic raw material for making this substance. Take the ethanol carefully and place it in a clean reaction vessel.
Furthermore, prepare P - Toluenesulfonyl chloride, which is a key reagent. Take an appropriate amount of p - toluenesulfonyl chloride and slowly add it to the reaction vessel containing ethanol. When adding, be sure to pay attention to the speed to prevent the reaction from being too dramatic.
To promote the reaction between the two, it is often necessary to add acid binding agents, such as pyridine. Pyridine can be combined with the hydrogen chloride generated by the reaction to make the reaction proceed in the direction of generating Ethyl + P - Toluenesulfonate.
When reacting, the temperature should be controlled. Usually the reaction can be started at low temperature, and then gradually heated to a moderate temperature to facilitate the reaction. This process requires fine observation of the reaction phenomenon. If the temperature is too high, the side reaction may occur and the product will be impure.
After the reaction is completed, the unreacted raw material and low boiling point impurities can be removed by distillation. The product is then extracted with an appropriate solvent, and then purified by drying and recrystallization to obtain pure Ethyl + P - Toluenesulfonate.
When operating, it is necessary to strictly follow the procedures and pay attention to safety to prevent the reagent from hurting people, so as to make Ethyl + P - Toluenesulfonate smoothly.
What are the chemical reactions of Ethyl P-Toluenesulfonate?
In the field of organic chemistry, ethyl p-toluenesulfonate often involves many reactions.
One is a nucleophilic substitution reaction. In this case, the nucleophilic reagent can attack the carbon atom connected to the sulfonate group in the ethyl p-toluenesulfonate, and the sulfonate group leaves as a good leaving group. If an alcohol is used as a nucleophilic reagent, the oxygen atom of the alcohol has a lone pair of electrons, which has good nucleophilicity and can attack the carbon atom to form ether compounds. During the reaction, the nucleophilic properties of the nucleophilic reagent, the steric resistance of the substrate, and the reaction conditions all affect the reaction process and product formation. If the nucleophilic reagent has strong nucleophilic properties and the steric resistance of the substrate is small, the reaction is easy to occur.
The second is the elimination reaction. Under basic conditions, ethyl p-toluenesulfonate can undergo elimination reaction. The base will capture the hydrogen atom on the adjacent carbon atom of the carbon atom connected to the sulfonate group, and the sulfonate group will leave to form an olefin. The strength of the base, the reaction temperature and other factors are related to the direction of the elimination reaction. The conditions of strong base and high temperature are more conducive to the elimination reaction.
Third, in some metal-catalyzed reaction systems, ethyl p-toluenesulfonate can also participate in the reaction. Metal catalysts can activate substrates and promote coupling reactions with other organic reagents. In this process, the type of metal catalysts and the structure of ligands play a key role in the selectivity and efficiency of the reaction. From this perspective, ethyl p-toluenesulfonate provides an important approach and method for the preparation of various organic compounds due to its diverse chemical reaction properties in the field of organic synthesis.
What should be paid attention to when storing and transporting Ethyl P-Toluenesulfonate?
Ethyl + P - Toluenesulfonate is a common compound in organic chemistry. When storing and transporting, many matters must be observed.
Bear the brunt, pay attention to the temperature and humidity of the environment. This compound is quite sensitive to temperature, and high temperature can easily cause it to decompose and deteriorate, so it should be stored in a cool place, and the temperature should not exceed 25 ° C. And humidity also has an impact. In the case of excessive humidity, or adverse reactions such as hydrolysis, the humidity should be controlled between 40% and 60%.
Furthermore, it has certain chemical activity and can react with many substances. When storing, it must be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed in storage and transportation to prevent dangerous chemical reactions, fires, explosions and other disasters.
Packaging is also crucial. It must be contained in well-sealed packaging containers. Commonly used glass bottles, plastic drums, etc., must ensure that there is no leakage. If the packaging is damaged, not only the compounds are easy to dissipate, but also may pose a threat to the environment and personal safety.
During transportation, the choice of vehicles should not be ignored. Vehicles with good ventilation equipment should be selected to dissipate harmful gases that may be generated. Escort personnel must also be familiar with their characteristics and emergency response methods. In the event of an emergency, they can respond quickly to ensure the safety of transportation.
All of these are for those who should pay attention to the storage and transportation of Ethyl + P - Toluenesulfonate, and must not be negligent to ensure its quality and safety.