Products

Ethyl Tosylate~P-Toluenesulphonic Acid Ethyl Ester

Lingxian Chemical

Specifications

HS Code

692106

Chemical Formula C9H12O3S
Molar Mass 200.25 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 240 - 245 °C
Density 1.116 g/cm³ at 25 °C
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Flash Point 110 °C
Odor Pungent
Packing & Storage
Packing Ethyl Tosylate, 500g, packaged in a tightly - sealed, corrosion - resistant bottle.
Storage Ethyl Tosylate (P - Toluenesulphonic Acid Ethyl Ester) should be stored in a cool, dry area away from heat sources, flames, and strong oxidizing agents. Keep it in a tightly - sealed container to prevent moisture absorption and evaporation. Store it in a well - ventilated chemical storage cabinet, following local safety and regulatory guidelines to avoid potential hazards.
Shipping Ethyl Tosylate (P - Toluenesulphonic Acid Ethyl Ester) is shipped in well - sealed, corrosion - resistant containers. Special handling guidelines due to its chemical nature are followed to ensure safe transport, protecting from heat, moisture, and mixing with incompatible substances.
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Ethyl Tosylate~P-Toluenesulphonic Acid Ethyl Ester
General Information
Historical Development
Ethyl Tosylate is ethyl p-toluenesulfonate, and the development of this substance has its own origins. In the past, chemical research was at the beginning of its rise, and various scholars were diligent in the field of organic synthesis.
At that time, the understanding of organic compounds was still shallow, but the public was determined to study it. After years of experiments, under specific reaction conditions, the method of preparing Ethyl Tosylate was obtained. The process was difficult, and the researchers repeatedly adjusted the ratio, temperature, and duration of the reactants.
With the passage of time, the technology improved, and the preparation process gradually matured. Later scholars, on the basis of predecessors, continued to optimize to improve the yield and purity. This compound is widely used in the field of organic synthesis, playing an important role in the development of chemistry and witnessing the evolution of synthetic chemistry.
Product Overview
Ethyl Tosylate, or ethyl p-toluenesulfonate, is an important compound in organic synthesis. It is a colorless to light yellow liquid with specific chemical properties and reactivity.
This compound is often used as an alkylation reagent, which can introduce ethyl into a specific organic molecular structure in the organic synthesis step. Its preparation is mostly obtained by esterification of p-toluenesulfonate and ethanol under suitable reaction conditions.
Ethyl Tosylate is widely used in pharmaceutical chemistry, materials science and other fields. In the process of drug synthesis, it can help to construct key drug molecular structural fragments; in material synthesis, it can also provide effective structural units for the synthesis of materials with specific properties. Due to its unique chemical properties, it plays a key role in various organic synthesis reactions, promoting the sustainable development and innovation of related fields.
Physical & Chemical Properties
Ethyl Tosylate is ethyl p-toluenesulfonate, which has unique physical and chemical properties. Its color is pure and transparent, showing a flowing shape, like smart water. Looking at its physical state, it is a liquid at room temperature, like a smart fluid, flowing freely. Smell its smell, it has a slight aroma, leisurely like the light fragrance of flowers.
When it comes to chemistry, Ethyl Tosylate is abnormally active. In its molecular structure, sulfonate groups are the source of activity. When encountering nucleophiles, they will react quickly as if they were friends. In the field of organic synthesis, it is like a smart dancer, capable of introducing ethyl groups, which contribute to the construction of complex molecules. And its stability is also exquisite, avoiding hot topics and fire sources, in order to ensure its stability, safely in the bottle, for scientific research, for the road of chemical exploration, to illuminate the way forward.
Technical Specifications & Labeling
Ethyl Tosylate, that is, P-Toluenesulphonic Acid Ethyl Ester is also. Its manufacturing technology is very important. This thing needs to be determined according to the method of precision. The raw materials are high, and the ratio must be high. The reverse degree and quality are all controlled. The finished product is obtained, and its color is clear and low. The amount of quantity also needs to be appropriate. The quality of the product should be followed, so that each product is suitable for the standard, so that it can be used for good products.
Preparation Method
Ethyl Tosylate is ethyl p-toluenesulfonate. The method of preparation is related to the raw material and production process, reaction steps and catalytic mechanism.
Prepare p-toluenesulfonic acid and ethanol as raw materials, and mix the two in an appropriate ratio. In the reaction vessel, add an appropriate amount of catalyst, such as sulfuric acid. Heat the mixture to maintain a suitable temperature and reaction time.
The reaction step is the esterification of the sulfonic acid group of p-toluenesulfonic acid with the hydroxyl group of ethanol. Sulfuric acid catalyzes this process to accelerate the reaction.
The catalytic mechanism is that sulfuric acid can protonate the hydroxyl group of ethanol, enhance its nucleophilicity, and thus more easily react with the sulfonic acid group of p-toluenesulfonic acid. Through this series of operations, Ethyl Tosylate can be obtained. In this way, the product can be obtained with reasonable raw materials and processes.
Chemical Reactions & Modifications
In the field of chemical industry, there is a thing called Ethyl Tosylate, also known as P-Toluenesulphonic Acid Ethyl Ester. Its chemical environment, reaction and chemical properties are quite studied by scholars.
Looking at its reaction, it often encounters various reagents according to specific rules, or replaces it, or adds it up, and changes thousands of times. Among the chemical properties, it has a certain activity, and under different conditions, it shows different states. Temperature, solvents, and other factors can make the reaction path and chemical properties appear different.
Scholars want to explore its details, and often set up various experiments. With a precise method, measure the rate of its reaction and observe the change of its chemical properties. At the end of the period, to clarify its inner principles, to achieve the essence of chemical technology, so that this substance in various fields, can be used to develop its growth, for the progress of the world, add bricks and mortar.
Synonyms & Product Names
Ethyl Tosylate is ethyl p-toluenesulphonic acid. The synonym and trade name of this product are of great research value. Its synonyms are P-Toluenesulphonic Acid Ethyl Ester. In the field of chemical research, different names may vary according to regions and habits.
In the past, chemists first dealt with this product, and it was given many names because of its unique structure and properties. With the deepening of research, its common name gradually became unified, but the old name is still used in some literature and industries.
The design of the trade name is mostly related to the manufacturer and product characteristics. Or to highlight the purity and use, the manufacturer has another name. This all reflects the complex and changeable names of chemical substances in historical evolution and commercial applications. The study of its synonyms and trade names is of great significance in chemical exchange, literature study, and product development.
Safety & Operational Standards
Ethyl Tosylate (P - Toluenesulphonic Acid Ethyl Ester) Safety and Operation Specifications
Ethyl ethanesulfonate, also known as ethyl p-toluenesulfonate, in the field of chemical research, its safety and operation standards are of paramount importance.
For storage, it should be placed in a cool, dry and well-ventilated place. This product is quite sensitive to moisture, and it is easy to deteriorate in case of moisture, which will damage its quality. Therefore, it should be stored in an airtight container away from water sources and places with high humidity to prevent it from contacting with external moisture. And it should be separated from oxidants, bases and other substances, because ethyl ethanesulfonate and other such substances are prone to chemical reactions, and even cause danger.
When operating, protective measures are indispensable. The experimenter must wear special protective clothing for the experiment and wear protective gloves to prevent it from touching the skin. Because it is corrosive to a certain extent, it can cause skin burns when touched. Also wear suitable goggles to avoid ethyl ethanesulfonate splashing into the eyes. If it does not enter the eyes carefully, rinse with a lot of water immediately and seek medical treatment immediately.
It is necessary to operate in the fume hood. The volatile gas of ethyl ethanesulfonate may be irritating to the human respiratory tract. The fume hood can effectively discharge the volatile gas to protect the safety of the experimenter's breathing. The operation process should be strictly followed according to the process, and there should be no slack. When taking it, take a precise dosage to avoid spilling. If there is a spill, clean it up in an appropriate manner as soon as possible.
Disposal should not be ignored. It should not be dumped at will. Discarded ethyl ethanesulfonate should be handed over to a professional treatment agency in accordance with relevant regulations, and disposed of in an environmentally friendly and safe way to prevent it from causing pollution and harm to the environment.
In short, the safety and operation standards of ethyl ethanesulfonate are a must-observe principle for chemical researchers. It is related to personal safety and the smooth progress of experiments, and must not be ignored.
Application Area
Ethyl Tosylate is ethyl p-toluenesulfonate, which is used in various fields. In the field of organic synthesis, it is often used as an alkylation agent. If you want to form ether compounds, Ethyl Tosylate can react with alcohols in a base environment, and borrow the mechanism of nucleophilic substitution to obtain the corresponding ether.
In the pharmaceutical industry, it also plays an important role. In the synthesis path of some drugs, Ethyl Tosylate is used to introduce specific alkyl structures to help build the skeleton of drug active molecules and optimize the physical and chemical properties and biological activities of drugs.
In addition, in the field of materials science, it may participate in the preparation process of some functional materials, giving materials unique properties. In conclusion, Ethyl Tosylate, with its unique chemical properties, has shown key value in many application fields and promoted the development and progress of various fields.
Research & Development
I dedicated myself to the research of Ethyl Tosylate, which is P-Toluenesulphonic Acid Ethyl Ester. This substance has a wide range of applications and is of great significance in the field of organic synthesis.
At the beginning, I explored the method of its preparation. After many attempts, I adjusted the temperature of the reaction and the ratio of reagents. Check the efficiency of different catalysts, or accelerate the reaction, or increase the purity of the product.
Then, study the properties of this substance, observe its chemical activity, and its stability in different environments. Know that it can react with many reagents to derive new compounds.
Thinking about the development of this substance, hoping to expand its application scope and make new breakthroughs in medicine and materials. We hope to improve its yield and quality in a better way, contributing to the progress of chemistry and benefiting the development of many fields.
Toxicity Research
Study on the toxicity of Ethyl Tosylate (Ethyl p-toluenesulphonic Acid Ethyl Ester)
The toxicity of Ethyl Tosylate (P-Toluenesulphonic Acid Ethyl Ester) is currently under investigation. This substance may involve toxicity and may be potentially harmful to human health and the surrounding environment.
Detailed investigation of its chemical properties, active reaction, or interaction with molecules in organisms, causing changes in physiological functions. Experiments show that exposure to this substance can cause biological or existing lesions, such as organ damage and metabolic disorder.
And it is difficult to degrade in the environment, or accumulate in water and soil, endangering ecological balance. The possibility of biological enrichment also exists, and it rises along the food chain, eventually harming higher organisms.
Therefore, the toxicity of Ethyl Tosylate should not be underestimated, and its mechanism of action should be investigated in depth in the future, and preventive measures should be established to reduce its harm to life and the environment, so as to ensure the safety of all beings and the cleanliness of the environment.
Future Prospects
I try to devote myself to the research of Ethyl Tosylate, which is the compound of P-Toluenesulphonic Acid Ethyl Ester. Viewing its properties, it has unique properties, and it often exhibits wonderful effects in various chemical reactions.
Thinking about the future development, this compound may show its talents in the medical way. It can help the system of new drugs, and adjust the quality and efficacy of drugs by its nature, so that patients can benefit. And in the field of materials, it may be able to promote the production of new materials. With its characteristics, it can be given excellent properties and used to expand the environment of materials.
Also read the chemical industry, which may be a key agent to optimize the process and improve the rate and quality of production. Although there may be obstacles in the road ahead, I believe that with the wisdom and diligence of my generation, I will be able to overcome difficulties and make this integration shine in the future, develop endless possibilities, and contribute to the progress of the world.
Frequently Asked Questions
What are the common applications of P-Toluenesulphonic Acid Ethyl Ester in organic synthesis?
Ethyl Tosylate, that is, ethyl p-toluenesulfonate, has the following common uses in organic synthesis.
First, it can be used as an alkylation reagent. This is because ethyl can be transferred to other nucleophilic reagents under suitable conditions through nucleophilic substitution reactions in its structure. For example, in the reaction of many compounds containing nitrogen, oxygen and other nucleophilic atoms, ethyl will replace the active hydrogen in these compounds, resulting in the formation of new organic compounds. This process is like in the stage of chemical reactions, where the "role" of ethyl is cleverly placed in a new "position" to build a different chemical structure.
Second, Ethyl Tosylate can act as an intermediary in the synthesis of some complex organic molecules. Through its participation in the reaction, it can precisely modify and modify the molecular structure, just like an indispensable "transition material" when building exquisite buildings, helping to achieve the specific structure and function required by the target molecule.
Third, it can also play a role in some specific catalytic reaction systems, affecting the reaction process and product generation, just like a special "supporting role" in the "drama" of chemical reactions. Although it is not the protagonist, it has a significant effect on the direction of the "plot". In the field of organic synthesis, Ethyl Tosylate plays an important role in the process of constructing various organic compounds with its unique chemical properties, providing organic synthesis chemists with an effective tool to help them create a variety of organic compounds.
Ethyl Tosylate | P-Toluenesulphonic Acid Ethyl Ester?
There are several common methods for preparing ethyl p-toluenesulphonic acid ester (P-Toluenesulphonic Acid Ethyl Ester).
One is to make p-toluenesulphonic acid chloride react with ethanol under alkaline conditions. This is a classic method. The p-toluenesulphonic acid chloride is slowly added to the ethanol solution containing alkali. The base can be selected from pyridine, triethylamine or the like. The function of the base is to neutralize the hydrogen chloride generated by the reaction and promote the reaction to proceed in the direction of generating ethyl p-toluenesulphonic acid. Pay attention to the control of temperature during the reaction, generally between low temperature and room temperature, otherwise side reactions may occur. After the reaction, the pure product can be obtained through extraction, washing, drying, distillation and other steps.
Second, the esterification reaction is carried out with p-toluenesulfonic acid and ethanol as raw materials under the catalysis of concentrated sulfuric acid. Concentrated sulfuric acid not only acts as a catalyst, but also has the effect of water absorption, which can promote the equilibrium of the esterification reaction to move in the direction of the product. However, concentrated sulfuric acid is highly corrosive, and the reaction conditions need to be strictly controlled. First, mix p-toluenesulfonic acid and ethanol with an appropriate amount of concentrated sulfuric acid, and heat and reflux for a certain period of time. After the reaction, the product needs to be alkaline washed to remove the sulfuric acid, and then washed with water, dried, rectified, etc., to obtain a higher purity ethyl p-toluenesulfonic acid.
Third, the phase transfer catalysis method can also be used. In the water-organic two Sodium p-toluenesulfonate was reacted with ethylene halide as raw material. The phase transfer catalyst can transfer sodium p-toluenesulfonate from the aqueous phase to the organic phase and fully contact with ethylene halide. This method has mild reaction conditions, simple operation, and considerable yield. After the reaction, the target product can be obtained by separation, washing, drying, distillation and other operations.
What are the physical properties of P-Toluenesulphonic Acid Ethyl Ester?
Ethyl ethanesulfonate, that is, ethyl p-toluenesulfonate, has the following physical properties:
This substance is mostly colorless to light yellow transparent liquid at room temperature. Looking at its color, those who are pure have a light color, but if they contain impurities, the color may be slightly darker. It has a special smell, although not strong and pungent, but it is unique.
When it comes to volatility, ethyl ethanesulfonate has a certain degree of volatility. Under normal temperature, it can slowly evaporate into the surrounding air. This property also causes it to be in a closed space or have a certain odor accumulation.
In terms of density, it is slightly heavier than water. If it is placed in a container with water, it often sinks to the bottom. The density difference between it and water provides a physical basis for separating the two.
The solubility is quite special, and it can be well dissolved in organic solvents such as ethanol and ether. Due to the principle of similar phase dissolution, its structure has a certain affinity with organic solvents. However, in water, the solubility is limited and only slightly soluble.
Melting point and boiling point are also key physical properties. Its melting point is low, and it is not solid at room temperature. The boiling point is relatively high, and it needs to reach a certain temperature to boil into a gaseous state. This boiling point characteristic is extremely important in chemical operations such as distillation and purification, and it can be separated from other substances by precise temperature control.
To sum up, the physical properties of ethyl ethanesulfonate have far-reaching impact on the application of chemical industry, medicine and many other fields, providing a key theoretical basis for its separation, purification, storage and use.
Ethyl Tosylate | P-Toluenesulphonic Acid Ethyl Ester What are the precautions during storage and transportation?
Ethyl p-toluenesulphonic acid ester (Ethyl Tosylate, P-Toluenesulphonic Acid Ethyl Ester) is a commonly used reagent in organic synthesis. During storage and transportation, the following things should be noted:
First, the temperature and humidity of storage are very critical. This reagent should be stored in a cool and dry place. Due to high humidity or hydrolysis, high temperature may accelerate its chemical reaction and damage the quality of the reagent. It is necessary to avoid direct sunlight, light or cause it to undergo photochemical reactions and cause deterioration.
Second, the choice of container when storing should not be underestimated. Use a container with good sealing performance to prevent contact with air. Because it is easy to react with moisture and oxygen in the air. And the material of the selected container should not chemically react with the reagent. Containers made of glass or specific plastic materials may be suitable.
Third, ensure stability during transportation. Avoid violent vibration and collision to prevent reagent leakage due to damage to the container. If the temperature of the transportation environment changes greatly, temperature control measures should be taken to maintain a suitable temperature range.
Fourth, ethyl p-toluenesulfonate is toxic and corrosive. Storage and transportation personnel should take protective measures, such as protective clothing, gloves and goggles, to avoid contact and harm to the body. At the same time, storage and transportation sites should be equipped with emergency treatment equipment and materials. In the event of leakage and other accidents, they can be responded to in a timely manner.
What are the effects of P-Toluenesulphonic Acid Ethyl Ester on the environment and human health?
Ethyl Tosylate (P-Toluenesulphonic Acid Ethyl Ester) has an impact on both the environment and human health.
At one end of the environment, this substance may be quite persistent. If it is released in nature, it may be difficult to degrade rapidly, causing accumulation in soil and water bodies. And it may be harmful to aquatic organisms, or interfere with the balance of aquatic ecosystems, hinder the survival and reproduction of aquatic organisms, and affect the stability of the food chain.
As for human health, ethyl p-toluenesulphonic acid ester may be irritating. If it comes into contact with human skin and eyes, it can cause skin redness, pain, eye discomfort, and inflammation. If inhaled inadvertently, or irritate the respiratory tract, it can cause cough, asthma, etc. Long-term or repeated exposure may be potentially toxic, affecting the function of human organs, such as liver, kidneys, etc., or damaging the nervous system, causing dizziness, fatigue, and inattention. Studies have also shown that it may be mutagenic, increasing the risk of genetic material mutation. In the long run, it may be related to the occurrence of serious diseases such as cancer.
Therefore, when using and handling ethyl p-toluenesulfonate, extra caution should be taken and proper protective measures should be taken to reduce its harm to the environment and human health.