L(-)-10-Camphorsulfonyl Chloride (1R)-Camphor-10-Sulfonic Acid Chloride

L- (−) -10-camphor sulfonyl chloride ((1R) -camphor-10-sulfonate chloride) is widely used in the field of chemical medicine.
It is often a key reagent in organic synthesis. It can be used as a chiral aid to introduce chiral groups to help obtain optically pure compounds. Because of its unique three-dimensional structure, it can induce specific three-dimensional chemical results in reactions. For example, in an asymmetric synthesis reaction, it can form chiral esters or chiral amides by reacting with compounds containing active hydrogen, such as alcohols and amines, and through its chiral environment, guide the reaction to selectively generate products of a certain configuration, which is of great significance in the fields of drug development and total synthesis of natural products.
It is also indispensable in the preparation of medicine. It can participate in the synthesis of various drug intermediates to prepare chiral drugs with specific physiological activities. Due to its chiral characteristics, it can affect the interaction between drugs and biological targets, thereby affecting the efficacy and safety of drugs. The synthesis of many chiral drugs relies on its participation in the reaction to build key chiral structural units, so that the drug can precisely act on the target in the body, improve the efficacy and reduce the side effects.
And in the field of materials science, it can be used to prepare materials with special chiral recognition functions. For example, chiral chromatographic stationary phase, with its chiral properties, can achieve efficient separation of isomers of different configurations, and make great contributions to chemical analysis, drug quality control, etc.
In summary, L- (−) -10-camphor sulfonyl chloride has important functions in organic synthesis, pharmaceutical preparation, materials science and other fields, and is a key material for promoting the development of various fields.

L (-) -10-camphor sulfonyl chloride ((1R) -camphor-10-sulfonyl chloride) is a chemical commonly used in chemical experiments and industrial production. During storage and transportation, many points should be paid attention to.
When storing, the first environment is dry. Because it is easy to hydrolyze in contact with water and causes deterioration and failure, it should be placed in a dry warehouse. The humidity should be controlled in a specific range, away from water sources and moisture. And the product is sensitive to heat, and high temperature can easily cause decomposition or other adverse reactions. It should be stored in a cool place, and the temperature should not exceed the [specific temperature]. At the same time, it should be stored in a well-ventilated place to prevent the accumulation of volatile gases from causing danger. Due to its certain toxicity and corrosiveness, it must be separated from food, drugs and other incompatible substances, and clear warning signs must be set up to prevent accidental touch and misuse.
During transportation, the packaging must be firm and tight. Use suitable containers to ensure that no leakage is damaged during bumps and collisions. The means of transportation must also be clean and dry, and there are no substances that may react with them. Transport personnel should be professionally trained and familiar with their characteristics and emergency treatment methods. Pay close attention to changes in temperature and humidity during transportation, and take necessary control measures. In the event of a leak, deal with it immediately according to the emergency plan, evacuate personnel, seal off the scene, and clean up and dispose of it by professionals to prevent the spread of pollution and ensure the safety of personnel and the environment.

The chemical synthesis method of L- (−) -10-camphor sulfonyl chloride ((1R) -camphor-10-sulfonyl chloride) has been around for a long time. The first method is to start with (1R) -camphor-10-sulfonic acid and treat it with chlorination reagents such as thionyl chloride. In this method, (1R) -camphor-10-sulfonic acid is placed in a reactor, and sulfoxide chloride is added in an appropriate proportion, heated and stirred. Sulfoxide chloride is used as a chlorination agent and a dehydrating agent. The sulfonic acid reacts with sulfoxide chloride. After the substitution process, the hydroxyl group of the sulfonic acid group is replaced by a chlorine atom, and then L- (−) -10-camphor sulfonyl chloride is obtained. After the reaction is completed, the unreacted raw materials and by-products are removed by distillation, extraction
Another method is to use camphor as the starting material. First oxidize camphor to obtain (1R) -camphor-10-sulfonic acid. This oxidation process can be reacted with suitable oxidants, such as potassium permanganate, under appropriate conditions. After obtaining (1R) -camphor-10-sulfonic acid, then according to the above method of chlorination with thionyl chloride, it is made into L- (−) -10-camphor sulfonyl chloride. Although this approach is slightly complicated, the raw material camphor is easy to obtain, and the cost may be advantageous.
Another method is to react with camphor derivatives with other sulfur-containing reagents. If a specific mercaptan derivative is reacted with an appropriate derivative of camphor in the presence of a catalyst, through a series of conversions, a sulfonyl chloride group is introduced, and finally L- (−) -10-camphor sulfonyl chloride is obtained. However, these methods require strict reaction conditions, complicated operation, and often require fine control of the reaction temperature, time, and reagent ratio, so they may not be as widely used as the former two.

L- (−) -10-camphor sulfonyl chloride ((1R) -camphor-10-sulfonate chloride) is an important chiral reagent in the field of organic synthesis. It often plays a key role in introducing chiral centers in the preparation of many fine chemical products such as medicines, pesticides, and fragrances. Regarding the manufacturer of this reagent, there are many well-known companies in China.
First, Shanghai banner search biochemical technology joint stock company, which is called a leader in the chemical reagent industry. It focuses on the research and development, production and sales of scientific research reagents, and its product line is extremely rich, covering all kinds of organic reagents, analytical reagents, etc. In the production of L- (−) -10-camphor sulfonyl chloride, the company relies on advanced technology and strict quality control system, and the reagents produced are of high purity and high quality, which are widely praised by scientific researchers and corporate customers. The products are sold nationwide and exported to many overseas countries and regions.
Second, Tixi Ai (Shanghai) Chemical Industry Development Co., Ltd., as a well-known chemical supplier, is also involved in the production of L- (−) -10-camphor sulfonyl chloride. This company inherits the advanced technology and management experience of the Japanese headquarters, and focuses on product quality and technological innovation. The L- (−) -10-camphor sulfonyl chloride produced by it occupies a place in the market with stable quality and good performance, and provides high-quality raw materials for many chemical enterprises and scientific research institutions.
Furthermore, Sinopharm Group Chemical Reagent Co., Ltd. is a large-scale and influential chemical reagent supplier in China. With its deep industry heritage and strong capacity, it produces L- (−) -10-camphor sulfonyl chloride with stable and reliable quality and strong supply capacity, which can fully meet the diverse needs of different customers. It has a wide range of customer groups in chemical, pharmaceutical and other industries.
These several manufacturers, with their excellent technology and reliable quality, have emerged in the field of L- (−) -10-camphor sulfonyl chloride production, making significant contributions to the development of the industry.

L- (−) -10-camphor sulfonyl chloride ((1R) -camphor-10-sulfonate chloride), as an organic compound with a specific chiral structure, has a unique chemical activity and can react with many other compounds, showing rich and diverse reaction possibilities.
First, it can react with alcohols, and this reaction follows the classical nucleophilic substitution mechanism. The hydroxyl oxygen atom of the alcohol launches a nucleophilic attack on the sulfonyl carbon atom of L- (−) -10-camphor sulfonyl chloride with its lone pair electrons, and the chloride ion leaves as a good leaving group, eventually generating the corresponding sulfonate. This reaction is of great significance in the field of organic synthesis, and is often used to construct ester compounds with specific functions, which are widely used in many disciplines such as medicinal chemistry and materials science.
Second, when it encounters amine compounds, L- (−) -10-camphor sulfonyl chloride also undergoes nucleophilic substitution. The nitrogen atom of the amine carries a lone pair of electrons, which carries out nucleophilic attack on the sulfonyl carbon atom, and the chloride ions leave to form sulfonamide products. Sulfonamide compounds play an important role in drug development, and many biologically active drug molecules contain this structural unit.
Third, under basic conditions, L- (−) -10-camphor sulfonyl chloride can undergo hydrolysis reaction. Hydroxide ions attack the sulfonyl carbon atom, chloride ions leave, and then go through a series of proton transfer steps to generate (1R) -camphor-10-sulfonic acid. This hydrolysis reaction has important application value in the preparation of specific chiral sulfonic acid compounds.
In addition, L- (−) -10-camphor sulfonyl chloride may also participate in some more complex organic reactions, such as condensation reactions with compounds containing active methylene catalyzed by bases, so as to construct more complex organic molecules, providing a rich strategy and approach for the development of organic synthesis chemistry.