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What is the chemical structure of L-Isoleucine Benzyl Ester 4-Toluenesulphonate?
The chemical structure of L-isoleucine benzyl ester p-toluenesulfonate is quite elegant. This compound is composed of three key structures.
The first is the L-isoleucine unit. L-isoleucine is an essential amino acid for the human body and has a specific chiral configuration. It contains amino groups (-NH ²) and carboxyl groups (-COOH), which are of great significance in constructing the structure of the compound and determining the chemical activity. The carboxyl group is combined with benzyl alcohol by esterification to form the benzyl ester structure. Benzyl ester part, benzyl group is composed of benzene ring-linked methylene (-CH ²), benzene ring has a conjugated system, which endows the compound with certain stability and hydrophobicity, and methylene acts as a connection bridge, so that the benzene ring is connected to L-isoleucine carboxyl group.
Furthermore, it is the radical part of p-toluenesulfonic acid. The root of p-toluenesulfonic acid is p-toluenesulfonic acid, containing benzene ring, methyl (-CH 🥰) and sulfonic acid group (-SO 🥰). The benzene ring and methyl enhance the hydrophobicity of the molecule, and the sulfonic acid group is strongly acidic. After ionization, a sul In L-isoleucine benzyl ester p-toluenesulfonate, the sulfonate anion binds to the L-isoleucine benzyl ester cation by ionic bonding.
In the structure of this compound, the L-isoleucine benzyl ester cation interacts with the p-toluenesulfonate anion electrostatically to maintain the overall structure stability. This structure makes the compound widely used in organic synthesis and medicinal chemistry. For example, it can be used as an intermediate for the preparation of drug molecules with specific activities. Its structural properties also affect the physical and chemical properties such as compound solubility and reactivity.
What are the physical properties of L-Isoleucine Benzyl Ester 4-Toluenesulphonate?
L-Isoleucine benzyl ester p-toluenesulfonate is an important compound in organic chemistry. It has many physical properties. Looking at its appearance, it is often in the state of white to white crystalline powder, which is easy to handle and measure in many chemical reactions and industrial applications.
When it comes to solubility, this substance exhibits certain solubility in common organic solvents such as ethanol and chloroform. Ethanol is a commonly used organic solvent, and L-Isoleucine benzyl ester p-toluenesulfonate can be moderately dissolved into it to form a homogeneous solution. This property is of great significance in the selection of reaction media for organic synthesis, because it can fully contact the reactants and promote the reaction.
Furthermore, its melting point is also a key physical property. After experimental determination, it has a specific melting point range, and this melting point characteristic can be used for purity identification. If the purity is high, the melting point range is relatively narrow and approaches the theoretical value; if it contains impurities, the melting point may decrease and the melting range becomes wider.
In addition, the compound has good stability in air, but it is exposed to high temperature, high humidity environment for a long time, or due to factors such as moisture absorption and oxidation, its properties change. Therefore, when storing, it should be placed in a dry and cool place to ensure the stability of its physical properties. In subsequent use, it should exert its due chemical efficacy.
Where is L-Isoleucine Benzyl Ester 4-Toluenesulphonate used?
L-Isoleucine benzyl ester p-toluenesulfonate is used in many fields such as medicine and chemical industry.
In the field of medicine, it plays a key role in the synthesis of peptide drugs. When preparing peptide drugs, specific amino acid derivatives need to be used as building blocks. L-Isoleucine benzyl ester p-toluenesulfonate contains isoleucine structure, and isoleucine is one of the essential amino acids of the human body. With this material, isoleucine can be precisely introduced into the polypeptide chain to synthesize polypeptide drugs with specific physiological activities. For example, some polypeptide drugs used to regulate human metabolism and enhance immune function are often used in the synthesis process.
In the chemical industry, it is used in the preparation of organic synthetic materials. Because of its special chemical structure, it can be used as a reaction intermediate to participate in the synthesis of polymer. By polymerizing with other monomers, it can endow materials with special properties. For example, when preparing some polymer materials with good biocompatibility and degradability, L-isoleucine benzyl ester p-toluenesulfonate can participate in the reaction as a functional monomer, so that the final material can be used in the field of biomedical engineering, such as tissue engineering scaffold materials. At the same time, in the synthesis of fine chemical products, it is an important organic raw material and can be used to synthesize fine chemicals with special structures, such as surfactants with specific structures, to meet different industrial production and scientific research needs.
What is the synthesis method of L-Isoleucine Benzyl Ester 4-Toluenesulphonate?
To prepare L-isoleucine benzyl ester 4-toluenesulfonate, the method is as follows:
Take L-isoleucine first and place it in an appropriate reaction vessel. Use an organic solvent such as dichloromethane, etc., to fully dissolve it to form a uniform solution. This solvent needs to be stable in nature, do not react with the reactants and products additionally, and have good solubility to each substance.
Then in this solution, slowly add benzyl alcohol. The amount of benzyl alcohol, when stoichiometric, is slightly excessive to promote the reaction in the direction of ester formation. At the same time, add an appropriate amount of catalyst, such as p-toluenesulfonic acid. The function of a catalyst is to accelerate the reaction process and reduce the activation energy required for the reaction.
During the reaction process, the temperature and stirring rate need to be controlled. The temperature should be maintained within a certain range, usually between room temperature and moderate heating, such as 40-60 degrees Celsius. The stirring rate should also be moderate to allow the reactants to fully contact and ensure that the reaction proceeds uniformly. The reaction lasts for several hours, depending on the monitoring of the reaction process. The degree of the reaction is usually tracked by thin-layer chromatography (TLC). When the raw material point disappears or the expected conversion rate is reached, the reaction can be regarded as completed.
Then, post-treatment is carried out. First, the reaction solution is washed with an appropriate amount of dilute alkali solution to remove excess catalyst and unreacted acid impurities. The concentration of alkali solution should not be too high to avoid damaging the product. The product is then extracted with an organic solvent, the organic phases are combined, and dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. After drying, the organic solvent is removed by reduced pressure distillation to obtain a crude product.
Finally, the crude product is purified. Often by recrystallization, suitable solvents are selected, such as ethanol-water mixed solvents. After multiple recrystallization, pure L-isoleucine benzyl ester can be obtained.
To obtain L-isoleucine benzyl ester 4-toluenesulfonate, the benzyl ester product is reacted with 4-toluenesulfonic acid in an organic solvent in an appropriate ratio. Control the reaction conditions to make it full of salts. After the reaction, the target product L-isoleucine benzyl ester 4-toluenesulfonate can be obtained by cooling, filtering and drying.
What is the market price of L-Isoleucine Benzyl Ester 4-Toluenesulphonate?
The market price of L-isoleucine benzyl ester p-toluenesulfonate is difficult to make a conclusion. The price often fluctuates due to various reasons.
As far as the raw materials are concerned, if the raw materials required for the synthesis of this compound, such as L-isoleucine, benzyl alcohol, p-toluenesulfonic acid, are abundant in output, widely sourced and easy to obtain, the cost will decrease, and the price of this compound may also decrease; on the contrary, if the raw materials are scarce and difficult to purchase, the price will rise, and eventually the market price of the finished product will rise.
The simplicity of the process is also the key. If the preparation process is exquisite, the process is short and the yield is high, and many complicated steps and costs are saved, the price can be close to the people; if the process is tortuous, time-consuming and labor-intensive, and special conditions and equipment are required, the cost is high, and the price is difficult to be low.
The situation of market supply and demand has a particularly huge impact. If in many fields such as pharmaceuticals and chemicals, the demand for this compound is strong, and the demand exceeds the supply, the merchant will raise the price to obtain a large profit; if the market is sluggish, the demand is few, and the supply exceeds the demand, the price will drop for promotional sales.
In addition, the world is complex, the current situation is turbulent, policy changes, logistics freight increases and decreases, etc., can all affect the cost and price. Therefore, in order to know the exact market price of L-isoleucine benzyl ester p-toluenesulfonate, it is necessary to investigate the raw materials, processes, supply and demand and various external conditions, and study them in detail.
