Methyl O-Toluenesulfonate

Lingxian Chemical

Specifications

HS Code	518788
Chemical Formula	C8H10O3S
Molar Mass	186.23 g/mol
Appearance	Colorless to pale yellow liquid
Odor	Characteristic odor
Density	1.18 g/cm³ (approximate)
Boiling Point	248 - 250 °C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in many organic solvents
Flash Point	113 °C (closed cup, approximate)

Packing & Storage

Packing	100g of Methyl O - Toluenesulfonate in a sealed, chemical - resistant plastic bottle.
Storage	Methyl O - Toluenesulfonate should be stored in a cool, dry, and well - ventilated area, away from heat sources, flames, and ignition points due to its potential flammability. Keep it in a tightly sealed container to prevent vapor release and protect from moisture which may cause degradation. Store separately from oxidizing agents, acids, and bases to avoid chemical reactions.
Shipping	Methyl O - Toluenesulfonate, a chemical, must be shipped in accordance with strict hazardous materials regulations. Use appropriate containers to prevent spills, with proper labeling indicating its nature for safe and compliant transportation.

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General Information

Historical Development

Methyl O-Toluenesulfonate is also an organic compound. It originated from the evolution of chemical technology. At the beginning, chemists explored the method of organic synthesis, and studied many times in sulfonation reactions.
In the past, organic synthesis was still in its infancy, and many reactions were not perfect. However, scholars have been determined to gradually understand the mechanism of sulfonation and esterification of aromatics. After years of trial and error, the method of preparing methyl o-toluenesulfonate was obtained.
With the passage of time, the synthesis method has advanced day by day, from crude to subtle, and the yield and purity have increased. This compound is widely used in the field of organic synthesis, and is of great importance to the pharmaceutical, materials, and other industries.

Product Overview

Methyl phthalenesulfonate is an important reagent in organic synthesis. Its color is clear and transparent, and it has a special smell. This compound is obtained by the esterification reaction of o-toluenesulfonic acid and methanol.
In the field of organic synthesis, methyl phthalenesulfonate has a wide range of uses. Often used as a methylating agent, it can introduce methyl groups into many organic molecules to assist in the construction of various complex compounds. Due to the reactivity of sulfonate groups in its structure, the reaction conditions are relatively mild and the selectivity is also good. When preparing
, the reaction temperature, raw material ratio and other conditions need to be controlled to obtain products with high yield and high purity. In short, methyl phthalenesulfonate plays an important role in the development of organic synthetic chemistry, providing a powerful tool for chemical researchers to explore new compounds and develop new reactions.

Physical & Chemical Properties

Methyl O-Toluenesulfonate, its physical and chemical properties are particularly important. Looking at its shape, it is often a colorless to light yellow liquid with a special odor. In terms of its melting and boiling point, the melting point is quite low, and it is liquid at room temperature. The boiling point varies according to external pressure. Its density is heavier than that of water. When placed in water, it must sink to the bottom.
In terms of solubility, it can be soluble in many organic solvents, such as ethanol and ether, but its solubility in water is limited. From the perspective of chemical properties, its chemical activity is quite high, and the sulfonate base in the molecule is active. It is easy to react with a variety of nucleophiles and can participate in many chemical reactions such as alkylation. The physical and chemical properties of this compound are widely used in the field of organic synthesis, and can provide key raw materials and intermediates for many reactions.

Technical Specifications & Labeling

Nowadays, there are chemical products called Methyl O - Toluenesulfonate. Its process specifications and identification (product parameters) are of paramount importance.
On the process specifications, the preparation method needs to follow the precise process. The choice of materials must be pure and the proportion should be appropriate. The temperature and pressure of the reaction are fixed, and no deviation should be made to ensure the quality of the product. And when operating, the equipment should be clean to prevent impurities from mixing.
As for the identification (product parameters), its characteristics, purity, molecular weight, etc. should be clearly marked. The characteristics, color, taste and form should be described in detail one by one. The purity geometry needs to be accurate, which is the basis of quality. The value of molecular weight cannot be ignored, it is related to its nature and use. In this way, in order to clarify its characteristics, it is easy to identify and use, and it is smooth in the chemical industry.

Preparation Method

To prepare Methyl O-Toluenesulfonate, it is necessary to clarify its raw materials, production process, reaction steps and catalytic mechanism.
It is appropriate to choose phthalenesulfonic acid and methanol as raw materials. The phthalenesulfonic acid and an appropriate amount of methanol are placed in the reaction kettle, and the two are the reaction initiators. Sulfuric acid is added as a catalyst to promote the reaction. The temperature is heated to a suitable temperature, about 60 to 80 degrees Celsius, which is conducive to the efficient occurrence of the reaction.
The reaction steps are as follows: The sulfonic acid group in the phthalenesulfonic acid is esterified with the hydroxyl group of methanol. Under the catalysis of sulfuric acid, the hydroxyl group of the sulfonic acid group is dehydrated and condensed with the methanol hydroxyl group to form methyl phthalenesulfonate
The catalytic mechanism is that sulfuric acid ionizes hydrogen ions, which enhances the positive electricity of carbonyl carbon atoms in o-toluenesulfonic acid, and the oxygen atoms of methanol are rich in electrons, which are easy to attack this carbon atom and push the reaction to the right. After the reaction is completed, pure methyl o-toluenesulfonate can be obtained through subsequent operations such as neutralization and purification.

Chemical Reactions & Modifications

The industry of chemical industry is related to people's livelihood, and its changes in things are wonderful. Today there is Methyl O-Toluenesulfonate, which is also an important element in the field of chemistry.
Looking at its chemical reaction, it often follows various laws. Temperature, pressure, and agent are all causes. Or combine with other things, or decompose themselves, each should follow the rules of chemistry. However, the nature of its reaction is not static.
If you want to improve its properties, you must study the physical properties in detail. Observe the structure of its molecules, analyze its electronic state, and find ways to change them. Or adjust temperature and pressure, or make it easy to touch the agent, all of which are expected to improve its chemical adaptability. Make this material more capable in the process of industry and scientific research, and benefit the world.

Synonyms & Product Names

Today there is a product called Methyl O - Toluenesulfonate. Its synonymous name, or called methyl o-toluenesulfonate. This chemical product has a wide range of uses and is an important raw material in the field of chemical industry.
Cover the chemical industry, all kinds of products depend on various raw materials. Methyl O - Toluenesulfonate has unique properties and can meet the needs of diversity. Or participate in the reaction to make other compounds; or as an auxiliary to help the smooth process.
The name of its product, called by the market, is also methyl o-toluenesulfonate. This name is traded and circulated by all industry players, and is used in industrial networks. This synonymous name and the trade name, although different, actually refer to the same thing, in the chemical world, play its indispensable function.

Safety & Operational Standards

Safety and Operation Specifications of Methyl O - Toluenesulfonate
Methyl O - Toluenesulfonate is also a chemical product, which is useful in the field of production and workmanship. If you want to ensure its safety and security, clarify its properties, and keep it safe.
This product has certain danger. Its sexual activity, in case of fire or high temperature, there is a risk of explosion. And the skin, eyes and respiratory tract are irritated. If you are not careful, it may cause skin damage, burning pain, eye tingling, flow disease, and even harm breathing, causing chest damage and shortening.
To ensure safety, the operation is difficult, and it must be prevented. Wear antiseptic clothing and anti-corrosive gloves, and the eyes are also indispensable, so as to prevent the body from being connected. The operation is convenient for good operation, so that the air flow is good, and the harmful accumulation is avoided.
When taking and using, it is appropriate and careful. Measure with appropriate equipment, and do not exceed the required amount. If there is any leakage, that is, it is difficult. First cover it with adsorbed substances, such as sand and vermiculite, and collect it in the utensils for use, and place it according to the wall.
Where it is stored, it is difficult to dry and pass. Avoid fire and sources, and do not mix with oxidized substances, to prevent their transformation and re-generation.
Furthermore, those who work on this matter must be affected by the problem. If it is dangerous, understand the method, so as to avoid the problem and ensure safety.
In addition, the safe operation of Methyl O - Toluenesulfonate is essential. Keep it, it can avoid harm and benefit, and use it properly.

Application Area

Methyl O-Toluenesulfonate is an organic compound. Its application field is quite wide. In the field of organic synthesis, it is often used as an alkylation reagent. It can interact with many nucleophiles to achieve the construction of carbon-carbon bonds or carbon-heteroatomic bonds.
In the field of medicinal chemistry, with its unique reactivity, it helps to create new drug molecules. It can introduce specific functional groups to optimize the activity, solubility and stability of drugs.
In the field of materials science, it also has its own influence. Or it can participate in the synthesis of polymer materials, giving materials special properties, such as improving their mechanical properties and thermal stability. From this point of view, methyl phthalenesulfonate has important value in various application fields, and it is a substance that cannot be ignored in chemical research and industrial production.

Research & Development

The industry of chemical industry is changing with each passing day, and the research of materials is related to people's livelihood and national plans. In today's words, Methyl O - Toluenesulfonate, its research and progress are quite critical.
We study it, first study its nature, explore its structure, and clarify the principle of its reaction. Look at its state and changes under various conditions. Strive for accurate insight, and investigate every detail.
Then find its use, and think about where it can be developed. Industrial manufacturing, or pharmaceutical research and development, are all things to consider. We hope to use exquisite methods to make it effective and add brilliance to the industry.
Furthermore, consider the method of mass production. Seeking the goodness of craftsmanship, the control of cost, and the stability of quality. Although the road is blocked and long, we are unremitting and committed to the research and progress of Methyl O-Toluenesulfonate, hoping to achieve great success and benefit the world.

Toxicity Research

The toxicity of methyl-o-toluenesulfonate is studied in this study. The color of this substance is clear and the taste is light, but its nature is hidden and dangerous.
Initial observation of its effect on microorganisms, when placed in the bacterial flora, it can be seen that the reproduction of bacteria is hindered, and its vitality is gradually diminishing. After trying it with insects, the movement of the insects is sluggish, and the physiological function is also chaotic.
Investigate the reason, or because after the ester enters the body, it disrupts the order of biochemistry and disturbs the work of cells. Although it has been seen that its harm is limited to microorganisms and insects, it is necessary to prevent its danger to large objects and even human body. The researcher should be careful, probe its nature in detail, so that the world can understand its harm, prevent it from being sprouted, and avoid poisoning invading the living and leaving a disaster in the world.

Future Prospects

I have tried to study Methyl O-Toluenesulfonate, and I know that it has unlimited potential in the field of chemical industry. Although the technology has not been perfected today, looking at its future, the prospects are bright.
The system of Methyl O-Toluenesulfonate, if you have a clever method, can improve quality and efficiency. It can be used as a cornerstone in the pharmaceutical and material industries to help it flourish. In the future, it may be possible to borrow new technologies to make the yield surge, the cost drop sharply, and the quality is better.
And the field of its application will definitely be expanded. In medicine, it can become a wonderful medicine and eliminate human diseases; in materials, or create strange materials, it can meet the needs of the world. I believe that with time and unremitting research, Methyl O-Toluenesulfonate will be able to shine, contribute to the brilliance of the future, and lead the chemical industry towards a lofty realm, achieving extraordinary achievements.

Frequently Asked Questions

What are the main uses of Methyl O-Toluenesulfonate?

Methyl O-Toluenesulfonate has a wide range of uses. In the field of organic synthesis, it is often used as an alkylation reagent. The sulfonate group in its structure is a good leaving group. When encountering nucleophilic reagents, nucleophilic substitution reactions are prone to occur, which can introduce methyl groups into specific molecular structures to form new carbon-carbon bonds or carbon-hetero bonds to prepare a variety of organic compounds.
In pharmaceutical chemistry, it also plays an important role. In the pharmaceutical process, or it is used to construct the specific structure of pharmaceutical active ingredients to change the physical and chemical properties and biological activities of the compounds, and help to develop new drugs with high efficiency and low toxicity.
In the field of materials science, methyl phthalenesulfonate may participate in the preparation of some functional materials. With its alkylation ability, it modifies the surface or internal structure of the material to give the material special properties, such as improving solubility and stability.
In addition, it is also a commonly used intermediate in fine chemical production. After a series of reactions, many fine chemicals can be derived, such as fragrances, dyes and additives, to meet different industrial and daily needs.

What are the physical properties of Methyl O-Toluenesulfonate?

Methyl o-toluenesulfonate is an important compound in organic chemistry. Its physical properties are quite unique. Looking at its shape, under normal temperature and pressure, it often appears as a colorless to slightly yellow liquid, with a clear texture and fluidity.
When it comes to odor, the smell emitted by this substance is quite special and irritating, but it is not so strong and pungent that people can get a clear sense of smell if they smell it.
Its boiling point is also a key physical property. Under suitable conditions, the boiling point is in a specific numerical range, which makes the methyl o-toluenesulfonate change from liquid to gas at a specific temperature during heating.
Furthermore, the melting point also has its fixed value. When the temperature drops to a certain degree, the substance solidifies from liquid to solid, and this melting point is extremely important to define its phase transformation.
In terms of solubility, methyl phthalenesulfonate exhibits good solubility in specific organic solvents, such as some common aromatic hydrocarbon solvents, which can be miscible with each other to form a uniform solution system; however, in water, its solubility is relatively limited, which is closely related to the properties of the groups contained in its molecular structure.
Density is also a physical property that cannot be ignored. Compared with the density of water, methyl phthalenesulfonate has a specific density value, which affects its phase distribution when coexisting with liquids such as water, and is of great significance in many practical application scenarios.

What are the chemical properties of Methyl O-Toluenesulfonate?

Methyl-o-toluenesulfonate is an important compound in organic chemistry. It has unique chemical properties and has attracted much attention in many chemical reactions and industrial applications.
This compound is electrophilic, because the sulfonate group is a good leaving group. When encountering nucleophiles, it is easy to initiate nucleophilic substitution reactions. In case of alcohols, or ether compounds are formed; if it meets amines, it can produce amine-substituted products. This nucleophilic substitution reaction is widely used in the field of organic synthesis and is a key means to construct various organic molecular structures.
Furthermore, its stability also has characteristics. Under normal temperature and pressure, it is still stable. However, under specific conditions such as high temperature, strong base or strong oxidant, decomposition or other chemical reactions may occur. For example, in a strong alkali environment, sulfonate groups may be replaced by hydroxyl groups to form alcohol derivatives.
In addition, methyl phthalenesulfonate is also an important substrate in the study of some special reaction mechanisms. Its reactivity and selectivity provide opportunities for chemists to explore new reaction pathways and optimize reaction conditions. Through in-depth study of its participation in the reaction, the microscopic process of organic reactions can be gained insight, thereby improving the efficiency and accuracy of organic synthesis.

What is the production method of Methyl O-Toluenesulfonate?

To prepare methyl phthalenesulfonate, the first step is to prepare o-toluenesulfonyl chloride and methanol as materials. In a suitable reaction vessel, slowly drop o-toluenesulfonyl chloride into methanol at low temperature. When adding dropwise, pay close attention to changes in temperature to prevent overreaction. Usually, it is better to control the temperature at 0 to 10 degrees Celsius.
After adding dropwise, you can add an appropriate amount of acid binding agent, such as pyridine or triethylamine. The function of the acid binding agent is to combine with the hydrogen chloride generated by the reaction to promote the positive progress of the reaction. During this process, it is also necessary to maintain the low temperature state of the reaction system and continuously stir to ensure that the materials are fully mixed and the reaction is uniform.
After a certain period of time, the reaction process can be monitored by thin-layer chromatography or other suitable analytical means. When the reaction reaches the desired level, quench the reaction with an appropriate amount of water, and then extract the product with an organic solvent such as dichloromethane or ether. After extraction and stratification, the organic phase is collected and dried with anhydrous sodium sulfate or magnesium sulfate to remove the moisture.
After that, the crude product is distilled under reduced pressure by rotary evaporator to remove the organic solvent. The crude product can be refined by column chromatography or recrystallization to obtain high-purity methyl phthalenesulfonate. The entire preparation process requires strict compliance with experimental procedures and safety protection to ensure smooth operation and product quality.

What are the precautions for using Methyl O-Toluenesulfonate?

When using Methyl O-Toluenesulfonate, there are many precautions. This is a commonly used reagent in organic synthesis, but it is dangerous and needs to be used with extreme caution.
First safety protection. Because of its irritation or damage to the skin, eyes, and respiratory tract, when taking it, be sure to wear appropriate protective equipment, such as protective gloves, goggles, lab clothes, and gas masks, to prevent contact and inhalation.
The second is the operating environment. It is suitable to operate in a well-ventilated fume hood to ensure that harmful gases are discharged in time and avoid accumulation. And the operating table should be kept clean and tidy, free of debris interference, so as to operate in an orderly manner.
Furthermore, storage should not be ignored. It should be stored in a cool, dry and ventilated place, away from fire sources and oxidants. Because of its flammability, it can cause combustion and explosion in case of open flames and hot topics. It must be stored in isolation and strictly abide by chemical storage specifications.
The retrieval process needs to be operated precisely. According to the exact measurement required by the experiment, the measuring utensils need to be clean and dry to prevent impurities from mixing in. After use, properly seal the remaining reagents to prevent deterioration.
In addition, if you accidentally contact the skin or eyes during use, you should immediately rinse with a large amount of water and seek medical attention in time. If a leak occurs, quickly evacuate personnel to a safe area, cut off the fire source, avoid dust, carefully collect the leak in a suitable container, and dispose of it according to regulations. Do not discard it at will to prevent pollution of the environment. In conclusion, the use of methyl phthalenesulfonate requires every step to be rigorous in order to ensure the safety and smooth conduct of the experiment.