Methyl P-Toluenesulfonate

Lingxian Chemical

Specifications

HS Code	277654
Chemical Formula	C8H10O3S
Molar Mass	186.228 g/mol
Appearance	Colorless to light - yellow liquid
Boiling Point	262 - 265 °C
Melting Point	−32 °C
Density	1.172 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like ethanol, ether
Flash Point	129 °C
Vapor Pressure	Low vapor pressure
Stability	Stable under normal conditions

Packing & Storage

Packing	500g of Methyl P - Toluenesulfonate packaged in a sealed chemical - grade bottle.
Storage	Methyl P - Toluenesulfonate should be stored in a cool, dry, and well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent exposure to moisture and air, which could potentially degrade the chemical. Avoid storing near incompatible substances to prevent hazardous reactions.
Shipping	Methyl P - Toluenesulfonate is shipped with utmost care. Packaged in suitable, tightly - sealed containers compliant with chemical transport regulations. Shipped via carriers experienced in handling hazardous chemicals to ensure safe transit.

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General Information

Historical Development

Methyl P-Toluenesulfonate is also a product of organic chemistry. Its historical evolution begins in the past. At the beginning, Zhu Xian was in the field of organic synthesis, dedicated to studying and gradually touching this thing. At that time, the experimental method was still simple, but the understanding was not complete.
And as the years go by, the chemical skills are becoming more and more exquisite. Everyone has explored the reaction mechanism and synthesis path. The preparation of this product has changed from raw to skilled, and its application has also become wider. In the industry of organic synthesis, it is a key reagent, helping many reactions to run smoothly. Its development process, like the journey of the stars, gradually shines from the dim light, and finally becomes an indispensable part of the field of chemistry, laying the foundation for the progress of organic chemistry in later generations.

Product Overview

"Description of Methyl-p-Toluenesulfonate"
Methyl-p-toluenesulfonate is a commonly used reagent in organic synthesis. Its color is often colorless to slightly yellow transparent liquid with a specific odor. This product is chemically active and is a key player in many organic reactions.
Its preparation method is mostly obtained by reacting p-toluenesulfonyl chloride with methanol under suitable conditions. During the reaction process, factors such as temperature and pH need to be carefully controlled to ensure the purity and yield of the product.
In the field of organic synthesis, methyl-p-toluenesulfonate is widely used. It is often used as a methylation reagent to introduce methyl groups into many compounds, and then derive a variety of organic products, which contribute greatly to drug synthesis and material preparation. However, it is toxic and irritating to a certain extent. When operating, it is necessary to follow strict safety procedures and take protective measures to prevent endangering the health of the experimenter.

Physical & Chemical Properties

Methyl P-Toluenesulfonate, the product of chemical reaction. Its material has unique physical and chemical properties. Looking at its shape, it is often a colorless to slightly yellow liquid, clear and transparent, and stable under normal temperature and pressure.
In terms of its melting point, the melting point is quite low, and it is in a flowing state at room temperature, which is easy to operate. The boiling point varies according to the external air pressure. However, at normal pressure, the boiling point is suitably high, making it difficult to disperse at room temperature. Its solubility is also commendable. It is soluble in multiple organic solvents, such as alcohols and ethers, but its solubility in water is limited, because its molecular structure is hydrophobic.
And its chemical activity is active, often used as an alkylating agent in the field of organic synthesis, and has a wide range of uses. It can react with many nucleophiles to form new compounds. It is an important intermediate in organic synthesis and is important in the pharmaceutical, agricultural and chemical industries.

Technical Specifications & Labeling

There are chemical products today, called Methyl P-Toluenesulfonate. The technique of its production is related to technical specifications and identification (product parameters), which is very important.
If you want to make this product, you should follow strict methods. From the selection of raw materials, you need to carefully select, and impurities should not enter, so as to ensure the purity of the quality. When operating, parameters such as temperature and duration should be precisely controlled. If the temperature is too high or too low, too long or too short, it can cause changes in the product.
As for the identification (product parameters), it must be clear and clear. Its purity geometry and content should be accurately marked. In this way, the user can understand its characteristics and use it correctly. This technical specification and identification (product parameters) are the foundation of the product. If you keep it, you can get a good product. If you discard it, you will fall short, and it is impossible to ignore it.

Preparation Method

Methyl P-Toluenesulfonate is prepared by this method as follows:
Raw materials and production process: Take p-toluenesulfonate chloride and methanol as the main raw materials. In the reactor, dissolve it in a suitable solvent, and slowly add an appropriate amount of acid binding agent. This is the key step. When the two meet, a substitution reaction occurs.
Reaction steps: Control the temperature in a specific range, and do not make the temperature fluctuate greatly to ensure a smooth reaction. During this time, pay close attention to the progress of the reaction and monitor the changes of the reactants with instruments. When the reaction is complete, separate and purify it. Distillation is used to remove the solvent; followed by extraction, its impurities are removed to obtain a purer product.
Catalytic mechanism: The acid binding agent is crucial in the reaction. It can bind to the acid generated by the reaction, promote the right shift of the reaction equilibrium, and improve the yield of the product. And the selection of an appropriate acid binding agent has a significant impact on the reaction rate and product purity. In this way, methyl p-toluenesulfonate can be obtained.

Chemical Reactions & Modifications

I tried to study the chemical properties of Methyl P - Toluenesulfonate. The chemical properties of this compound are wonderful and interesting. In alkali, it often has nucleophilic substitution, and alkyl groups are easily replaced by other groups, such as alcohol groups, amine groups, etc., which can be substituted with it. This is the opposite.
As for the chemical properties, it has a high activity, because the sulfonyloxy group is a good group. This property makes it widely used in organic synthesis. However, due to its high activity, it needs to be carefully preserved to avoid contact with active substances.
From the perspective of Methyl P - Toluenesulfonate, it plays a pivotal role in the field of organic chemistry. Our research can explore new ways for organic synthesis and understand its principles before we can make good use of it.

Synonyms & Product Names

In the words of "Mengxi Written Talks", many different names are often sought for things. Today there is Methyl P - Toluenesulfonate, which is also called by various names in the world of industry and commerce.
Methyl P - Toluenesulfonate, commonly known as methyl p-toluenesulfonate. In the market, merchants may call it "methyl p-methanesulfonate", which is simply called for its structure and composition. There are also those who use the name "methyl toluenesulfonate", which is intended to be slightly more complex and important.
The various different names of the watcher, although the name is different, all refer to the same thing. This chemical product is widely used in the field of industry. It is either a raw material for organic synthesis, or a key reagent in the reaction. Although the various aliases cause a little confusion, those who understand their properties and know their uses can distinguish them without error, which does not harm their use in industry and is used in various production.

Safety & Operational Standards

Methyl P - Toluenesulfonate, chemical products are also used. In the room and in the work environment, its safety and operation are of paramount importance.
Where this object is connected, the first priority is safety. It is appropriate to prevent damage, such as anti-clothing, gloves, eyes, etc., to prevent skin damage and eye contact. Because of its irritation, if accidentally contaminated, immediately wash with a lot of water for treatment.
The operation environment is convenient and good, to avoid its steaming fatigue. If it is stored, it should be stored in the warehouse, dry and dry, fire source, oxidation, and stored in a fixed division to prevent accidents.
In the operation of the warehouse, follow the operation process. When it is used, it is advisable to use used utensils, measure them accurately, and avoid wave pollution. After use, properly clean up the utensils, and do not drop them at will.
In the workplace, it is more necessary to control the quality of each product. Raw materials, reverse process to finished product package, all are safe and controlled. Work

Application Area

Methyl P-Toluenesulfonate is widely used in various fields. In the field of organic synthesis, it is often used as an alkylation agent. It can react with nucleophiles such as alcohols and phenols to introduce methyl groups to form new compounds, which contribute to the construction of organic molecular structures.
In the pharmaceutical and chemical industry, it may be involved in the preparation of pharmaceutical intermediates. The precise introduction of specific groups to change the properties of drug molecules, such as enhancing their biological activity and improving solubility, is of great help to the research and development of new drugs.
In the field of materials science, or in the synthesis of polymers. Participate in polymerization reactions, adjust the structure and properties of polymers, and produce materials with special functions, such as high mechanical properties and excellent thermal stability, to meet diverse needs.

Research & Development

Since modern times, the technology of chemistry has advanced day by day, and many new substances have appeared. In this article, the research and development of Methyl P-Toluenesulfonate.
Study this substance, and the first thing to do is to make it. In the past, the production method was difficult, and the yield was not good. Today, Zhu Xian has worked hard to improve the process, so that the yield gradually increased and the quality was also excellent. It has a wide range of uses in the field of organic synthesis. It can be used as a reagent, introducing groups into compounds, and is the basis for the creation of new molecules.
However, its development has also encountered obstacles. Toxicity considerations and environmental impact are all difficult problems that cannot be ignored. Scholars have been thinking hard for good strategies, hoping to reduce its harm and improve its growth. With time, it will be able to rise to the next level and develop its extraordinary capabilities in the chemical industry, which will be used by the world and benefit all living beings.

Toxicity Research

"Methyl p-toluenesulfonate"
Today's research on the toxicity of methyl p-toluenesulfonate. This substance is pure in color and uniform in quality, but its properties should not be ignored. Look at the structure of its molecules, the atoms are connected in an orderly manner, or the cause of its toxicity.
Test it with various substances to observe its reaction. In the body of a white rat, when this agent is applied, the white rat is restless, then sluggish, and the body is trembling and hairy, and the toxicity is obvious. Its entry into the body may disrupt the order of cells and disturb the rules of metabolism.
And look at it in water, dissolving and dispersing, or it can be a sewage source, endangering living things. When aquatic things are encountered, their vitality is gradually lost, and their body shape is distorted.
In summary, methyl p-toluenesulfonate is toxic and harmful to living beings and the environment. Research, in order to prevent its abuse, ensure the safety of all living beings, and protect the peace of the world.

Future Prospects

I have been studying methyl p-toluenesulfonate for a long time. Looking at its properties, it can be used as an important reagent in various reactions, which can lead to the formation of new bonds and expand the field of chemical synthesis.
Looking to the future, methyl p-toluenesulfonate may make great progress in the creation of medicine. It can help to refine and create special drugs and solve the difficulties of many diseases. In material science, it is also expected to give birth to novel materials, which have advantages and are suitable for diverse needs.
Furthermore, study its green preparation method, reduce pollution and increase efficiency, and follow the times. With unremitting research, the potential of methyl p-toluenesulfonate will be fully developed, and it will create a bright new chapter for the advancement of chemistry and the prosperity of mankind, and open up unlimited new opportunities.

Frequently Asked Questions

What are the chemical properties of Methyl P-Toluenesulfonate?

Methyl p-toluenesulfonate is an important compound in organic chemistry. It has active chemical properties and often plays a key role in organic synthesis reactions.
From a structural perspective, the compound contains methyl and p-toluenesulfonate groups. P-toluenesulfonate is a good leaving group, which gives it high activity in nucleophilic substitution reactions. Because the negative ions formed after the p-toluenesulfonate leaves have good stability, it can promote the reaction to advance towards nucleophilic substitution.
In many organic synthesis scenarios, methyl p-toluenesulfonate is often used as a methylation reagent. For example, when it encounters an alcohol compound, the oxygen atom of the alcohol will act as a nucleophile to attack the methyl carbon of the methyl p-toluenesulfonate, and then the p-toluenesulfonate will leave to form methyl ether compounds. This reaction is widely used in forming carbon-oxygen bonds and can be used to prepare a variety of organic compounds with ether structures.
Furthermore, it can also undergo nucleophilic substitution reactions with amine compounds. The nitrogen atom of an amine attacks the methyl group with its lone pair electron nucleophilic. After the p-toluenesulfonate leaves, methylated amine products are obtained. This process is of great significance in the modification and synthesis of nitrogen-containing organic compounds, and is helpful for the construction of nitrogen-containing functional molecules with different structures.
However, due to its reactivity, caution is required when storing and using methyl p-toluenesulfonate. It should be avoided from random contact with strong nucleophiles, strong bases and other substances to prevent unnecessary reactions. At the same time, because of its certain toxicity and irritation, it is necessary to strictly follow safety procedures during operation and properly handle it in a well-ventilated environment.

Methyl P-Toluenesulfonate is commonly used in which reactions

Methyl p-toluenesulfonate, this substance is often used in nucleophilic substitution reactions in organic synthesis. Because the sulfonate group is an excellent leaving group, it exhibits activity in many reaction systems.
Looking at nucleophilic substitution reactions, alcohols react with methyl p-toluenesulfonate, and hydroxyl groups can be replaced to form new organic compounds. For example, primary alcohol and methyl p-toluenesulfonate can react smoothly under the catalysis of bases to achieve the replacement of hydroxyl groups and obtain corresponding replacement products. In this process, bases play a key role in assisting the conversion of alcohol hydroxyl groups into more nucleophilic alcohol oxygen anions, thereby enhancing the reactivity.
Furthermore, in the reaction of amine compounds, methyl p-toluenesulfonate can also participate. The nitrogen atom of amine is nucleophilic and can attack the carbon atom of the sulfonate, causing the sulfonate group to leave and achieving the alkylation reaction of the amine. This reaction is widely used in the construction of nitrogen-containing organic molecular structures, and it is also common in many drug synthesis pathways.
In addition, in the synthesis strategies of some complex organic molecules, methyl p-toluenesulfonate is often used as a key intermediate. By rationally designing the reaction steps and taking advantage of its active reaction characteristics, the construction of the carbon skeleton of the target molecule and the transformation of functional groups can be realized, which can help to synthesize organic compounds with exquisite structures and specific biological activities or material properties. It plays an important role in the field of organic chemistry synthesis and provides an effective tool for chemists to prepare various compounds.

What are the preparation methods of Methyl P-Toluenesulfonate

There are several common methods for preparing Methyl P-Toluenesulfonate.
First, p-toluenesulfonyl chloride (p-Toluenesulfonyl Chloride) and methanol (Methanol) are used as raw materials and react in an alkaline environment. This reaction needs to be handled with caution, because p-toluenesulfonyl chloride is active. Take an appropriate amount of p-toluenesulfonyl chloride first, slowly add it to the reaction vessel containing methanol, and add an appropriate amount of base such as Pyridine (Pyridine) or triethylamine (Triethylamine) at the same time. The function of the base is to neutralize the hydrogen chloride (Hydrogen Chloride) generated by the reaction, so that the reaction balance moves in the direction of the product. During the reaction, the temperature needs to be controlled moderately, usually between low temperature and room temperature, to prevent side reactions from occurring. After the reaction is completed, methyl p-toluenesulfonic acid ester can be obtained by extraction, washing, drying, distillation and other steps.
Second, p-toluenesulfonic acid (p-Toluenesulfonic Acid) is reacted with diazomethane (Diazomethane). Although diazomethane is highly reactive, it is highly toxic and explosive, and special care must be taken during operation. Dissolve p-toluenesulfonic acid in a suitable solvent such as ether, and slowly introduce diazomethane gas under low temperature and dark conditions. This reaction is rapid and the yield is quite high. After the reaction is completed, the target product can be obtained after appropriate post-treatment, such as reduced pressure distillation to remove the solvent and unreacted diazomethane.
Third, react p-toluenesulfonic anhydride with methanol. P-toluenesulfonic anhydride can react with methanol under mild conditions. Mix the two in the reaction vessel, and a small amount of catalyst such as sulfuric acid (Sulfuric Acid) or p-toluenesulfonic acid can be added to catalyze itself. During the reaction process, pay close attention to temperature changes to avoid product decomposition or side reactions caused by excessive temperature. After the reaction is completed, pure methyl p-toluenesulfonic acid ester is obtained by conventional separation methods such as filtration and distillation.

What should be paid attention to when storing Methyl P-Toluenesulfonate?

When storing methyl p-toluenesulfonate, be sure to pay attention to many matters. This is because of its unique chemical properties, and a little carelessness can cause disasters.
Temperature and humidity of the first storage environment. It should be placed in a cool and dry place to avoid high temperature and humidity. High temperature can accelerate its chemical reaction or cause decomposition; humid environment can easily make the material absorb moisture, affecting its purity and stability. Therefore, the temperature of the storage place should be controlled in a suitable range, and the humidity should not be too high.
The second is related to the choice of storage container. Suitable containers must be used, usually made of corrosion-resistant materials, such as glass or specific plastic materials. Because of its active chemical properties, contact with improper materials, or react, damage the substance itself, or cause damage to the container, causing the risk of leakage.
Furthermore, isolated storage is necessary. Do not coexist with oxidizing, reducing substances and alkaline substances in the same room. Methyl p-toluenesulfonate encounters such substances, or causes violent chemical reactions, and even explodes and fires, endangering safety. Therefore, in storage places, it is necessary to strictly classify to ensure mutual isolation.
In addition, the storage place should be equipped with perfect ventilation equipment. If there is a small amount of leakage, good ventilation can disperse the volatile gas in time, reduce the concentration of harmful substances in the air, prevent its accumulation and cause explosion risk, and protect the health of operators.
Finally, the identification of the storage area must be clear and clear. Mark the information such as the name of the substance, characteristics, hazards and emergency response methods, so that the relevant personnel can see at a glance. Once something happens, the correct measures can be taken quickly according to the label to reduce the hazards. In this way, the safety of the storage of methyl p-toluenesulfonate can be ensured.

What are the market application fields of Methyl P-Toluenesulfonate

Methyl p-toluenesulfonate is widely used in the chemical industry.
First, it is an important reagent in the field of organic synthesis. It can be used as an alkylation reagent and participates in many organic reactions. For example, in the preparation of ether compounds, methyl p-toluenesulfonate can react with alcohols under suitable conditions to generate corresponding ethers through nucleophilic substitution processes. This reaction is a common method for forming carbon-oxygen bonds in the synthesis of fine chemicals. In the synthesis of nitrogen-containing heterocyclic compounds, it can react with nitrogen-containing nucleophiles, introduce methyl groups, change the structure and properties of the compounds, and create key intermediates for new drug development, materials science and other fields.
Second, the field of medicinal chemistry is also indispensable. In the process of drug molecule construction, it is used to modify specific functional groups. When some drug lead compounds are optimized, methyl p-toluenesulfonate is used to introduce methyl groups, which may improve the pharmacokinetic properties of drugs such as fat solubility and metabolic stability. For example, in the development of some anti-tumor drugs, such modifications make it easier for drugs to pass through the biofilm, enhance the efficacy and reduce toxic and side effects.
Furthermore, in terms of materials science, methyl p-toluenesulfonate participates in the synthesis of polymer materials. When preparing a polymer with a specific structure, it can participate in the polymerization reaction as a monomer or initiator to regulate the chain structure and properties of the polymer. Such as the preparation of functional polymer membrane materials, through its participation in the reaction, the material is endowed with special separation, adsorption and other properties, and plays a role in gas separation, wastewater treatment and other environmental fields.
Overall, methyl p-toluenesulfonate has significant uses in organic synthesis, pharmaceutical chemistry, materials science and many other fields, promoting technological innovation and development in various fields.