Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester

Lingxian Chemical

Specifications

HS Code	650860
Chemical Formula	C8H10O3S
Molar Mass	186.23 g/mol
Appearance	Colorless to light - yellow liquid
Boiling Point	262 - 264 °C
Melting Point	−32 °C
Density	1.187 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, ether
Flash Point	122 °C
Odor	Characteristic pungent odor
Cas Number	80 - 48 - 8

Packing & Storage

Packing	100g of Methyl P - Tosylate in a sealed, chemical - resistant container.
Storage	Methyl p -Tosylate (4 - Methylbenzenesulfonic Acid Methyl Ester) should be stored in a cool, dry, well - ventilated area, away from heat sources and ignition sources. It should be kept in a tightly sealed container to prevent moisture absorption and vapor leakage. Store it separately from oxidizing agents and bases to avoid potential chemical reactions.
Shipping	Methyl p -Tosylate (4 - Methylbenzenesulfonic Acid Methyl Ester) is shipped in well - sealed, appropriate containers. These are carefully packaged to prevent spills and ensure safety during transportation, adhering to chemical shipping regulations.

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Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester

General Information

Historical Development

The industry of chemical industry is changing with each passing day, and many wonders have emerged over the years. Today, this thing is called Methyl P-Tosylate (4-Methylbenzenesulfonic Acid Methyl Ester), and its function is quite obvious in the field of chemical industry.
Trace back to its origin, in the past, chemical research has not been as detailed as it is today. However, a group of wise men, diligent in exploration, in the secret of material changes, and unremitting research. At the beginning, only a little understanding of its nature, after years of work, experiments have not been calculated, and it is clear that its preparation method and properties are wonderful.
From the crude methods of the past to the mature craftsmanship of the present, its development path has been tortuous and difficult. The progress of the past may have been slow due to the rudimentary utensils and shallow cognition, but the predecessors were determined to accumulate a few steps and reach a thousand miles, so that this thing has gradually appeared in the world. In the chemical industry, it can be used by future generations. The achievement of today's situation depends on the diligent exploration of the predecessors.

Product Overview

Methyl P-Tosylate (4 - Methylbenzenesulfonic Acid Methyl Ester) is a commonly used reagent in organic synthesis. It is a colorless to light yellow liquid with a specific odor. This compound is prepared by esterification of p-toluenesulfonic acid and methanol.
Methyl p-toluenesulfonate has a wide range of uses in the field of organic synthesis. It is often used as an alkylation reagent to alkylate nucleophiles and introduce methyl and p-toluenesulfonyloxy groups. It plays an important role in drug synthesis, materials science and other fields. Due to its active chemical properties and high reactivity, it participates in many organic reactions and provides an effective way to construct complex organic molecular structures.

Physical & Chemical Properties

"On the Physical and Chemical Properties of Methyl P - Tosylate 4 - Methylbenzenesulfonic Methyl Ester"
Hydrolysis of methyl p-toluenesulfonate is also an organic chemical. Its physical properties are mostly colorless and transparent liquid at room temperature, with a special odor and slightly volatile. The density is moderate, about [X] g/cm ³, slightly soluble in water, but can be miscible with many organic solvents, such as ethanol and ether.
On its chemical properties, the existence of ester groups makes it hydrolytic. In water or alkaline environment, it is easy to hydrolyze into p-toluenesulfonic acid and methanol. And its sulfonate group activity is quite high, often used as a good leaving group in nucleophilic substitution reactions, and can react with a variety of nucleophilic reagents to generate new organic compounds. This property is widely used in the field of organic synthesis and is also commonly used by organic chemists.

Technical Specifications & Labeling

Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester is also a chemical product. Its process specifications and identification (product parameters) are crucial. The production of this product also requires a precise method. The purity of the raw materials, the temperature of the reaction, and the control of time are all key.
As far as the label is concerned, the name should be accurate, and the characteristics should be clear, such as the genus of color, state and taste. And the content is geometric, and the number of impurities should be detailed. This product is widely used in various fields of chemical industry, but its specifications and labels are the basis of quality. Users rely on it to ensure everything goes smoothly, without fear of safety and efficacy. Strict adherence to process specifications and clear identification parameters are the only way to make this product.

Preparation Method

The method of preparing Methyl P - Tosylate 4 - Methylbenzenesulfonic Acid Methyl Ester is related to the raw materials and production process, reaction steps and catalytic mechanism.
The selection of raw materials, when p-toluenesulfonic acid and methanol is appropriate. The production process first puts the two in an appropriate proportion in the reactor, and adds an appropriate amount of catalyst, such as sulfuric acid. The reaction steps are as follows: Heat the reactor to a specific temperature, about 60 to 80 degrees Celsius. At this temperature, p-toluenesulfonic acid and methanol are esterified. The reaction formula is: p-toluenesulfonic acid + methanol + methyl p-toluenesulfonic acid ester + water. The catalytic mechanism of
is that sulfuric acid can provide protons to promote the reaction to form methyl p-toluenesulfonate. During the reaction process, attention should be paid to temperature and time control to ensure that the reaction is sufficient and the purity and yield of the product are improved. After the reaction is completed, pure methyl p-toluenesulfonate can be obtained by separation and purification.

Chemical Reactions & Modifications

Methyl P - Tosylate is 4 - Methylbenzenesulfonic Acid Methyl Ester. The reaction and change of this substance are essential for chemical research. The reaction is in contact with various reagents, or nucleophilic substitution, or esterification genus. When the nucleophilic reagent arrives, the thioester bond is easily broken, and the new bond is formed, resulting in a different product.
As for the change of its chemicity, temperature, pressure, and catalyst all have an effect. When the temperature rises, the reaction rate increases, the molecular energy is high, and the collision frequency is frequent and the effect is good. The change of pressure responds to the gas phase. For catalysts, the energy barrier decreases, and the reaction is easy to advance, but the quality and quantity are constant.
From this perspective, the study of the transformation of this thing should be combined with the change of transformation, and it is necessary to synthesize various causes in order to understand the reason and lay the foundation for the reality.

Synonyms & Product Names

Methyl P - Tosylate, also known as 4 - Methylbenzenesulfonic Acid Methyl Ester, is a commonly used reagent in organic synthesis. There are also many aliases, all of which exist due to industry habits and regional differences.
This product has a clear and transparent color, a liquid state, and a specific odor. In the chemical industry, it has a wide range of uses and is often a key player in organic synthesis reactions. It plays an important role in etherification, esterification and other reactions, assisting in the preparation of many fine chemicals.
Due to its chemical activity, it can interact with a variety of compounds, so it is also highly valued in the fields of drug synthesis, materials science, etc. Chemists often rely on its characteristics to construct complex organic molecular structures in experimental investigations to achieve the desired research purposes. Although the name of this reagent is different, its essence and function are constant, and it is indispensable for chemical research and industrial production.

Safety & Operational Standards

"Methyl p-toluenesulfonate (Methyl 4-methylbenzenesulfonate) Safety and Operation Specifications"
Methyl P-Tosylate (4 - Methylbenzenesulfonic Acid Methyl Ester) is a commonly used reagent for chemical preparation. To clarify its safety and operation specifications, it is essential.
Its sexual characteristics are certain hazards, touching the skin, inhalation or accidental ingestion can cause human damage. Therefore, when operating, it must be fully protected. Wear protective clothing, such as lab clothes and gloves, with a texture that can prevent its penetration. Wear protective goggles to prevent splashing into the eyes. The mouth and nose should not be ignored, and a gas mask should be equipped to filter out harmful gases.
The operating environment must be well ventilated, and a fume hood should be set up. If the gas escapes, it can be dissipated quickly, avoiding the accumulation of space and reducing the risk of poisoning. When taking it, the action should be steady and careful to avoid its leakage. The amount is precisely controlled. According to the needs of the experiment, do not overdo it.
When storing, choose a cool, dry and ventilated place. Keep away from fire and heat sources to prevent them from being decomposed by heat and causing danger. Store separately from oxidants, alkalis, etc., to avoid chemical reactions and cause disasters.
If unfortunately spilled, do not panic. Quickly evacuate personnel to a safe area and prohibit unrelated people from entering. Emergency responders wear full masks and chemical protective clothing, and cut off the leakage source first. Small leaks should be absorbed with inert materials such as sand and vermiculite, put into a closed container, and disposed of according to regulations. Large leaks should be embankment and contained, and transferred to a tanker or a special collector with an explosion-proof pump for recycling or harmless treatment.
In short, the safety and operation standards of methyl p-toluenesulfonate are related to the safety of the experimenter and the success of the experiment. It should not be ignored and should be strictly followed.

Application Area

Methyl P-Tosylate, that is, methyl p-toluenesulfonate, also known as 4-Methylbenzenesulfonic Acid Methyl Ester. This substance has important applications in many fields.
In the field of organic synthesis, it is often used as a methylating agent. Because the sulfonate group in its structure is a good leaving group, under appropriate conditions, it is easy to undergo nucleophilic substitution reaction with nucleophiles to achieve methylation modification of compounds. For example, in drug synthesis, it can be used to introduce methyl groups to change the physicochemical properties and biological activities of drug molecules.
In the field of materials science, it participates in the preparation process of specific polymer materials. With its chemical reactivity, it can adjust the structure and properties of materials, providing a way for the synthesis of materials with special properties.
However, it should be noted that this compound is toxic and irritating, and it is necessary to follow strict operating procedures and take protective measures during use to ensure the safety of personnel and the environment from pollution.

Research & Development

In recent times, the art of chemistry has become increasingly refined, and the properties and systems of all things have become clear. Today there is Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester. We investigate it to understand its rationale and seek its progress.
Begin to explore its structure in detail, analyze its atomic rows and bonds, and know its essence. Repeat its properties, observe its transformation under different circumstances, measure its melting boiling and solubility. Examine its system and try various methods, seek simplicity and excellence, and hope to increase its production and reduce its consumption.
In the process of research, we have encountered many problems, but we are not discouraged, but more courageous. With scientific methods, reasoning and argumentation, repeated experiments. Today, it has been achieved, its nature is gradually becoming clear, and the system is also good. However, learning is endless, we should continue to study it, and hope that in the future, this thing can shine in the fields of work and medicine, and be used by the world to promote the progress of the world.

Toxicity Research

Toxicity of Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester. This substance is a commonly used reagent in organic synthesis. After various experiments, it can show toxic effects on tested organisms under specific conditions. When tested with insects, touched or eaten, it can be seen that the movement is delayed, the growth is hindered, and even death. In aquatic organisms, it can cause water pollution and affect their survival and reproduction. The reason is that the chemical structure of this substance has specific activities, and it is easy to interact with molecules in organisms to disrupt physiological processes. Although its toxicity is gradually being studied, its toxicity may vary in different environments and biological systems, and further investigation is needed to clarify its overall picture and ensure environmental and biological safety.

Future Prospects

I have tried to study Methyl P-Tosylate 4-Methylbenzenesulfonic Acid Methyl Ester, which has shown its ability in organic synthesis. Looking at the current situation, although its properties are already known, there is still a long way to go to achieve the delicate state.
Looking forward to the future, it may be possible to find breakthroughs in the reaction conditions. Hope to find milder temperatures and pressures, making the reaction easy to control and efficient, saving energy and increasing production. Also hope that in the research and development of catalysts, we can obtain amazing things, greatly increase its rate, reduce costs and benefit environmental protection.
Furthermore, the field of its application is expected to expand. In addition to the current use, it may be able to emerge in the process of new materials and drug research and development, adding new brilliance to many fields and opening up infinite possibilities in the future, so as to achieve great things and benefit all people.

Frequently Asked Questions

What is the main use of methyl p-toluenesulfonate (methyl 4-methylbenzenesulfonate)?

4-Methylphenyl-p-toluenesulfonate (toluene 4-methylbenzenesulfonate) has a wide range of main uses. In the field of organic synthesis, it is often used as an alkylating agent. Due to its structure containing active ester groups, under appropriate reaction conditions, it can undergo nucleophilic substitution reactions with many nucleophilic reagents, thereby realizing the construction of carbon-carbon bonds or carbon-heteroatomic bonds. This is one of the key steps in the synthesis of complex organic compounds.
For example, in the field of medicinal chemistry, when synthesizing drug molecules with specific structures, 4-methylphenyl-p-toluenesulfonate can be used as an important intermediate to precisely introduce the required structural fragments by reacting with nucleophiles containing specific functional groups, so as to achieve the construction of target drug molecules.
Furthermore, in the field of materials science, it also has its uses. It can participate in the synthesis process of certain polymer materials, and through its reaction with other monomers or functional compounds, it can impart specific properties to the material, such as improving the solubility, thermal stability or mechanical properties of the material. By ingeniously designing the reaction path, its structure is introduced into the main chain or side chain of the polymer, and then the microstructure and macroscopic properties of the material are adjusted to meet the special requirements of material properties in different application scenarios.
In addition, in the preparation of fine chemicals, 4-methylphenyl p-toluenesulfonate can be used to synthesize fine chemicals with special functions, such as fragrances, dyes, etc. Using its reactivity to react with other organic compounds, fine chemicals with unique structures and properties are constructed to meet the market demand for high-quality and diverse fine chemicals.

What to pay attention to when storing methyl p-toluenesulfonate (methyl 4-methylbenzenesulfonate)

4-Methyl benzenesulfonate needs to pay attention to many matters when storing. This is an organic compound with certain chemical activity, so the temperature and humidity of the environment are crucial during the storage period. The temperature should be kept constant at a low temperature range of 2-8 ° C. If the temperature is too high, it will easily accelerate its chemical reaction, or cause decomposition and deterioration. The humidity should also be strictly controlled, and it should be maintained at 40% - 60%. If the humidity is too high, it may cause it to get damp, which will affect the quality.
Furthermore, it is necessary to pay attention to the ventilation conditions of the hidden place. It is necessary to ensure that the storage place is well ventilated to prevent the accumulation of volatile gases from the substance. First, it can avoid the safety risk caused by high gas concentration, and second, it can avoid adverse reactions with the components in the air.
In addition, this compound should be stored separately from oxidants, alkalis and other substances. Due to its active chemical properties, contact with oxidants or trigger violent oxidation reactions, resulting in serious consequences such as combustion and explosion; when it encounters alkalis, chemical reactions may also occur, destroying its chemical structure and affecting its use efficiency.
At the same time, the choice of storage containers should not be underestimated. It is advisable to choose corrosion-resistant materials, such as glass or specific plastic containers, and the containers must be well sealed to prevent their leakage, which not only avoids pollution to the environment, but also ensures that their quality is not disturbed by external factors.
During the storage process, it should also be checked regularly to see if there are any abnormal conditions such as leakage and deterioration. Once found, it needs to be properly handled in a timely manner to ensure safety.

What are the synthesis methods of methyl p-toluenesulfonate (methyl 4-methylbenzenesulfonate)?

To prepare methyl 4-methylbenzenesulfonate, there are various methods.
First, 4-methylbenzenesulfonate can be obtained by the sulfonation reaction of toluene and concentrated sulfuric acid, and then esterified with methanol under the action of acidic catalysts such as sulfuric acid. First, toluene is put into the kettle, and when it is cold, Xu injects concentrated sulfuric acid, stirres at controlled temperature, and sulfonates to obtain 4-methylbenzenesulfonate. This way, the raw materials are common, but the reaction conditions need to be carefully controlled, and the sulfuric acid is highly corrosive, and the post-treatment is also complex.
Second, take p-methylbenzenesulfonyl chloride and sodium methoxide as materials, and react with the two phases. First, sodium methoxide is prepared, and methanol is reacted with sodium metal. Next, the p-methylbenzenesulfonyl chloride is dissolved in a suitable solvent, such as dichloromethane, and the solution of sodium methanol is added slowly. The temperature control reaction is completed. After washing, drying, distillation and other methods, methyl 4-methylbenzenesulfonate can be obtained. This reaction condition is mild and the yield is good. However, it is irritating to methylbenzenesulfonyl chloride. Sodium methanol is flammable in contact with water, so the operation needs to be careful.
Third, it can be obtained by the reaction of 4-methylbenzenesulfonate sodium and di Sodium 4-methylbenzenesulfonate is prepared first, and then sulfonated with toluene and neutralized with alkali. Then it is co-placed with dimethyl sulfate in a reactor, reacted in an appropriate amount of water or organic solvent, and separated and purified to obtain the target. However, dimethyl sulfate is highly toxic, and protection must be comprehensive when using it, and the reaction products need to be carefully treated to prevent residual poisons.

What are the physical properties of methyl p-toluenesulfonate (methyl 4-methylbenzenesulfonate)

4-Methylphenylacetate ethyl ester is also an organic compound. Its physical properties are as follows:
Looking at its properties, at room temperature, it is mostly a colorless to light yellow transparent liquid. Under sunlight, it can be seen that it is clear and shiny, like a river of autumn water, without obvious suspended solids or impurities.
Smell its smell, often with a unique aromatic smell, but this aroma is not pungent and strong, but like a leisurely rhyme, faintly emitting, making people feel comfortable olfactory, or has a fruity aroma, or contains a little floral fragrance. Depending on the method of synthesis and purity, they all have a certain sense of pleasure.
In terms of its melting and boiling point, the melting point is usually low, and it is a liquid state at room temperature. Due to the moderate force between molecules, it cannot be condensed into a solid state at room temperature. The boiling point depends on its structure and purity, which is roughly within a certain range. It boils at a relatively moderate temperature and gasifies into a gaseous state. This property makes it possible to realize the phase transition of liquid and gas under specific temperature conditions. This property is of great significance in industrial and experimental operations.
Measuring its density, it is lighter than water. Mixing it with water shows that it floats on the water surface, just like oil floats on the water. The boundaries between the two are clear. Due to the way of molecular accumulation and the type and number of atoms, its density is less than that of water.
Its solubility is also an important physical property. In organic solvents, such as ethanol, ether, etc., it has good solubility and can be miscible with organic solvents to form a uniform solution. However, in water, the solubility is not good. Due to its hydrophobic molecular structure and weak interaction with water molecules, it is not easily soluble in water. This characteristic is used in separation, purification and application, and can be used for phase separation and other operations.
Its volatility is moderate, it does not evaporate rapidly like alcohol, and it is not an extremely difficult substance to evaporate. In an open environment, it will gradually evaporate over time, emitting its unique odor in the air. This property affects its storage and use environment. It is necessary to pay attention to sealing and storing to prevent volatilization loss.

Is methyl p-toluenesulfonate (methyl 4-methylbenzenesulfonate) toxic?

The so-called "ethyl-p-ethylthiosalicylic acid (ethyl 4-ethylthiosalicylic acid) " is a question of whether it is toxic or not, which is really related to the study of physical properties.
I have tasted the good work of ancient times, and I have examined all kinds of things in detail to understand their properties. The properties of this thing should also be explored in this way. Considering the classics, there is no direct discussion of the toxicity of this thing. However, looking at its composition, ethyl, thiosalicylic and other groups may have special properties in other things.
Sulfur is often unique in various compounds. Thiogroup, or make the chemical activity of this substance different from usual. And its role in the living body, or due to the interaction with various biomolecules vary. If it enters the organism, or comes into contact with key molecules such as proteins and nucleic acids, its reaction state cannot be determined.
However, only according to its name, its toxicity cannot be lightly judged. To understand, it is time to test it. Like the ancient alchemists, who tried various medicines with fire and observed their changes. Today, it is also time to use scientific methods to make this substance come into contact with biological cells, animal models, etc., and observe its impact on life activities. If the growth and metabolism of the cell are disturbed, or the animal shows signs of abnormality, it can be proved to be toxic; if there is no other way, it can be regarded as relatively harmless for the time being.
From this perspective, only for this name, the toxicity of "ethyl-p-ethylthiosalicylic acid (ethyl 4-ethylthiosalicylate) " is not enough, and it must be investigated in detail by scientific experiments before it can be determined.