Methyl P-Tosylate~P-Toluenesulphonic Acid Methyl Ester

Lingxian Chemical

Specifications

HS Code	810593
Chemical Formula	C8H10O3S
Molar Mass	186.23 g/mol
Appearance	Colorless to pale yellow liquid
Odor	Pungent
Density	1.18 g/cm³
Boiling Point	262 - 265 °C
Melting Point	18 - 21 °C
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents like ethanol, ether
Flash Point	110 °C
Refractive Index	1.526 - 1.528

Packing & Storage

Packing	500 - gram bottle of Methyl P - Tosylate / P - Toluenesulphonic Acid Methyl Ester.
Storage	Methyl p -Tosylate (p -Toluenesulphonic Acid Methyl Ester) should be stored in a cool, well - ventilated area away from heat, sparks, and open flames, as it is flammable. Keep it in a tightly sealed container to prevent moisture and air exposure, which could potentially cause decomposition. Store separately from oxidizing agents and bases to avoid chemical reactions.
Shipping	Methyl P - Tosylate (P - Toluenesulphonic Acid Methyl Ester) is shipped in tightly sealed, corrosion - resistant containers. It must be handled as a chemical of moderate risk and transported in accordance with strict chemical shipping regulations.

Free Quote

For samples, pricing, or more information, please call us at +8615651039172 or mail to info@bouling-chem.com.

We will respond to you as soon as possible.

Tel: +8615651039172

Email: info@bouling-chem.com

Methyl P-Tosylate~P-Toluenesulphonic Acid Methyl Ester

General Information

Historical Development

Taste the chemical industry, there is a thing called Methyl P - Tosylate, that is, methyl p-toluenesulfonate. Its beginning is also unknown to many wise men. After several generations of research, its properties gradually became clear.
At the beginning, the preparation method was not good, and the production was very few. The workers thought hard and worked hard over the years to get a good plan, so that the output gradually increased.
In the way of application, it was not widely used at the beginning. Later, the wise man observed its characteristics and found that it could be used in all kinds of organic synthesis, so it became an important tool in the industry. The road to its development, although not smooth, depends on the diligence of the public, gradually, and finally into today's grand view, in the field of chemical industry, occupy a place, benefit future generations, is a good example of technological evolution.

Product Overview

Methyl P-Tosylate (or P-Toluenesulphonic Acid Methyl Ester) is also an organic chemical substance. It is a colorless to slightly yellow liquid with a special odor. This compound is prepared by esterification of p-toluenesulfonic acid and methanol. In the field of organic synthesis, it has a wide range of uses and is often used as an alkylation agent to introduce methyl into specific organic molecular structures. Its reactivity is quite high, and it can react with many nucleophiles to generate various valuable products. Due to its unique chemical properties, it is an indispensable intermediate in the fields of drug synthesis, materials science, etc., helping researchers to achieve the construction of many complex organic molecules and promoting the development and progress of chemical science.

Physical & Chemical Properties

Methyl P-Tosylate (also known as methyl p-toluenesulphonic acid ester, P-Toluenesulphonic Acid Methyl Ester), its physical state is mostly colorless to slightly yellow liquid at room temperature. Looking at its properties, it has a special odor and certain volatility.
In terms of its chemical properties, the substance is relatively active, and the existence of ester groups makes it easy to react with nucleophiles, making it widely used in the field of organic synthesis. Its physical properties cannot be ignored, and parameters such as boiling point and melting point are of great significance for its separation, purification and storage.
However, when using this substance, it is necessary to pay attention to its safety. Due to its toxicity and irritation, strict regulations should be followed during operation to ensure the safety of the experimenter and the tranquility of the environment.

Technical Specifications & Labeling

Methyl P - Tosylate/P - Toluenesulphonic Acid Methyl Ester, its technical specifications and identification (product parameters) are the key. To view this compound, it is necessary to clarify its properties. It should be a colorless to slightly yellow liquid with a specific fragrance and no odor. Its purity, when measured at a very high standard, should not be less than 99%. The boiling point should be in a specific range, about 180 to 193 degrees Celsius, to ensure the stability of its physical properties. The density is also fixed, about 1.3 to 1.15 grams per cubic centimeter. And when storing and transporting, it must avoid strong light and hot topics to prevent qualitative changes. In this way, the technical specifications and identification essentials of this product can ensure its high quality and correct application.

Preparation Method

To prepare Methyl P - Tosylate/P - Toluenesulphonic Acid Methyl Ester, the raw materials and production process are the key. P - toluenesulphonic acid and methanol are often used as raw materials, which are inexpensive and easy to buy. The reaction process is as follows: p - toluenesulfonic acid is mixed with methanol, and at a specific temperature, sulfuric acid is used as a catalyst, and the esterification reaction occurs between the two.
The reaction steps are: first place an appropriate amount of p - toluenesulphonic acid and methanol in a certain proportion in the reactor, slowly add sulfuric acid, heat up to a suitable temperature, and continue to stir to make the reaction sufficient. This process requires precise temperature control to prevent side reactions. When the reaction is completed, the product is purified through neutralization, separation, distillation and other processes.
In order to increase the yield, the reaction conditions can be optimized. Such as accurately blending the proportion of raw materials, finding the best reaction temperature and duration, or selecting high-efficiency catalysts. Through this process, high-purity methyl p-toluenesulfonate can be prepared.

Chemical Reactions & Modifications

The wonders of chemical industry are related to the change of substances. For Methyl P-Toluenesulphonic Acid Methyl Ester (P-Toluenesulphonic Acid Methyl Ester), the chemical reaction and modification are considerable.
Looking at the reaction, it is often the characteristic of sulfonate, which interacts with nucleophiles such as alcohols and amines to form ether and amination products. The mechanism is the positive electricity of sulfur atoms in sulfonates, which leads to the attack of nucleophiles, breaks ester bonds and creates new bonds.
As for modification, or according to different needs, adjust its structure. On the aromatic ring, add a substituent to change its electron cloud density and change its reactivity. Or around the ester group, it changes its steric resistance, which affects the selectivity of its interaction with others.
The two, reaction and modification, complement each other, and expand thousands of paths and possibilities for many fields such as chemical synthesis and material preparation. It is the key to chemical research.

Synonyms & Product Names

In the field of chemical industry, there is a thing called "Methyl P-Tosylate", also known as "P-Toluenesulphonic Acid Methyl Ester". The nickname and trade name of this thing are also very meaningful. It may have various different names, which are well known in the industry.
Because of the variety of chemical categories, there are many things, which is a common thing. This "Methyl P-Tosylate" also has different names in the industry and is well known to all practitioners. Its trade name also varies slightly depending on the user and production and sales. However, it basically refers to the same thing. Although the names are different, their properties and uses are the same. The existence of many names is due to various reasons such as industry habits and regional differences, resulting in the same thing and multiple coexisting. It is also a common phenomenon in the exchange and practice of chemical industry.

Safety & Operational Standards

"Methyl-p-toluenesulfonate (methyl-p-toluenesulfonate) Product Safety and Operation Specifications"
Fuhmethyl-p-toluenesulfonate, also known as methyl-p-toluenesulfonate, is widely used in the field of chemical industry. However, its properties are potentially dangerous, so when handling, it is necessary to follow safety and operation specifications to ensure safety.
First words storage. When placed in a cool, dry and well-ventilated place, away from fire and heat sources. Do not mix with oxidants and alkalis to prevent reactions from changing and causing emergencies. Where it is stored, it is advisable to set up obvious warning signs to inform the viewer of its risks.
As for operation, practitioners must undergo professional training and be familiar with the procedures. When operating, be sure to wear suitable protective equipment, such as protective clothing, gloves and goggles, to avoid direct contact with the skin and eyes. If you work in a poorly ventilated place, you need to prepare an effective ventilation device to prevent the accumulation of steam and damage to people's health.
Furthermore, the action should be slow during use to avoid its splashing and leakage. Once it leaks, don't panic. Quickly cut off the fire source and evacuate others. Small leaks can be adsorbed by inert materials such as sand and vermiculite and put into airtight containers; if there are large leaks, the embankment will be blocked and transferred to a special container with an explosion-proof pump, and then properly disposed of.
Disposal should not be ignored. It should be handled by a qualified agency in accordance with local regulations, and it should not be discarded at will, so as not to pollute the environment.
In short, the handling of methyl-p-toluenesulfonate should be handled with caution, and this safety and operation code should be followed to achieve the safety and order of chemical production.

Application Area

Methyl P-Tosylate (methyl p-toluenesulphonic acid), also known as P-Toluenesulphonic Acid Methyl Ester, is used in many fields.
In the field of organic synthesis, it is often used as a methylation reagent. If you want to introduce a methyl group, you can use it to react with compounds containing active hydrogen, such as alcohols and phenols, to form methylation products. The ancient book goes: "If you want to make an alcohol to obtain a methyl group, co-locate it with Methyl P-Tosylate and supplement it with an appropriate agent, you can obtain a methylated alcohol, which adds a new substance to organic synthesis." The beauty of this reaction lies in the precise introduction of methyl groups to expand the structure of organic molecules.
It also plays an important role in drug development. Because it can modify the molecular structure of drugs, or can change the activity, solubility and other properties of drugs. For example, when developing a new type of drug, modifying the molecule with Methyl P-Tosylate may improve the efficacy of the drug. Ancient books also say: "In the research of drugs, using Methyl P-Tosylate to change its structure or increase its efficacy, and find a new way for the treatment of diseases."
Therefore, Methyl P-Tosylate is indispensable in the fields of organic synthesis and drug development. Its application prospect is broad, and it should be further explored.

Research & Development

The chemical industry is changing with each passing day, and the research of substances is related to people's livelihood. In this word, Methyl P-Tosylate, also known as P-Toluenesulphonic Acid Methyl Ester, this compound is also.
Our generation dedicated themselves to studying, exploring its properties, and studying its synthesis method. At the beginning, it was difficult and dangerous, and we tried many times to get a clue. With various reagents, follow the rules of chemistry, and gradually understand its reaction mechanism.
In the research and development process, strive to improve. Improve the process, improve the yield, and optimize the quality. Hope this product can be widely used, or for the help of medicine, or in the field of materials to emerge. Although the road ahead is long, we will uphold the spirit of research and make unremitting exploration, hoping to achieve great success and contribute to the development of the chemical industry for the benefit of the world.

Toxicity Research

Today there is a substance called "Methyl P-Tosylate", also known as "P-Toluenesulphonic Acid Methyl Ester". I take the study of toxicants as my business, and explore the toxicity of this substance in detail.
Looking at its properties, this chemical may react with other substances under specific conditions and derive various changes. Its effect on organisms should not be underestimated. After many experiments, if organisms come into contact with this substance, they may show discomfort or even endanger their health.
However, to understand its exact toxicity, more research is needed. It is necessary to carefully examine the factors such as dosage, route of exposure, and duration in order to accurately determine its impact on organisms and the environment. The study of poisons is related to the livelihood of all living beings. I will do my best to clarify the mystery of the toxicity of this substance and use it for the world to avoid its harm and pursue its benefits.

Future Prospects

Today there is a thing called "Methyl P - Tosylate", or "P - Toluenesulphonic Acid Methyl Ester". My generation is a chemical researcher, and we look forward to the future of this thing. It has great potential in the way of organic synthesis. It can be used as a key reagent to help many reactions move forward smoothly. In the future, it is expected to shine in the field of medical creation, adding bricks to the treatment of diseases and diseases; or it may emerge in the road of material research and development, giving materials new and peculiar properties. Although there may be thorns ahead, we firmly believe that with time and unremitting research, we will be able to tap its potential, bring many benefits to the world, achieve an extraordinary career, and develop its bright and bright future.

Frequently Asked Questions

What are the main uses of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester?

Methyl P - Tosylate or P - Toluenesulphonic Acid Methyl Ester has a wide range of main uses. In the field of organic synthesis, it is often used as a methylation reagent. In its molecular structure, methyl groups are active and can react with many nucleophiles, allowing the target molecule to introduce methyl groups, which is crucial in building the structure of complex organic compounds.
In pharmaceutical chemistry, its use is also quite significant. In drug development, it is often necessary to modify the structure of the lead compound by introducing methyl methanesulfonate, which can change the physicochemical properties of the drug, such as improving its fat solubility, making it easier for the drug to penetrate the biofilm, enhancing the absorption effect; or it can adjust the binding ability of the drug and the target to optimize the efficacy.
Furthermore, in the field of materials science, it can also be seen. In the preparation of some functional materials, methyl methanesulfonate can participate in the reaction to improve the specific properties of the material, such as adjusting the chemical properties of the material surface, enhancing its compatibility with other substances, and then expanding the application scope of the material. In conclusion, methyl methanesulfonate has important uses in various fields such as organic synthesis, pharmaceutical research and development, and materials science, and has made significant contributions to promoting the development of related fields.

What are the physical properties of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester?

Methyl methanesulfonate, also known as methyl p-toluenesulphonic acid ester (Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester), is an important compound in organic chemistry. The physical properties of this substance are crucial and are detailed as follows:
- ** Properties **: Usually colorless to yellowish liquid with a pure appearance and certain fluidity. This trait is the basis for intuitive judgment when it is identified and actually operated.
- ** Boiling point **: about 216-218 ° C. The characteristics of boiling point enable it to be distinguished from other substances by temperature differences in separation and purification operations such as distillation.
- ** Melting point **: Its melting point range is around -2.5 ° C, and the melting point is low, indicating that it is easy to maintain a liquid state at room temperature.
- ** Density **: about 1.187g/mL (20 ° C), this density value is very helpful for calculating its dosage and proportion in solution.
- ** Solubility **: Soluble in organic solvents such as ethanol and ether, in organic synthesis reactions, it provides a basis for selecting a suitable reaction medium. However, due to poor solubility in water, this property also affects its reaction process in different systems.
- ** Odor **: It has a weak and special odor. Although it is not pungent and foul, it is also an important clue to identify its existence. The physical properties of methyl methanesulfonate are of great significance in the fields of organic synthesis and chemical production, and are an important reference for relevant practitioners to implement operations and design experiments.

What are the synthesis methods of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester?

The synthesis methods of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester are as follows.
First, the esterification reaction is carried out by using p-toluenesulfonic acid and methanol as raw materials and catalyzed by concentrated sulfuric acid. In this process, concentrated sulfuric acid acts as a catalyst to promote the reaction of the two to form the target product. During the reaction, the p-toluenesulfonic acid and methanol are placed in a reaction vessel in a certain proportion, an appropriate amount of concentrated sulfuric acid is added, heated and stirred to promote the reaction. However, concentrated sulfuric acid is highly corrosive, and the operation needs to be cautious. The post-reaction treatment is also complicated, and the product and catalyst need to be properly separated.
Second, the reaction is carried out with p-toluenesulfonyl chloride and sodium methoxide as raw materials. Under suitable conditions, p-toluenesulfonyl chloride and sodium methoxide can smoothly form methyl p-toluenesulfonate. The reaction conditions of this method are relatively mild and the yield is considerable. During operation, the p-toluenesulfonyl chloride is slowly added to the solution containing sodium methoxide to control the reaction temperature and rate to ensure the smooth progress of the reaction. After the reaction is completed, the pure product can be obtained through appropriate separation and purification steps.
Third, it is synthesized by phase transfer catalysis. This method uses a phase transfer catalyst to make the reaction efficient in a two-phase system. For example, a quaternary ammonium salt phase transfer catalyst is used with sodium p-toluenesulfonate and halomethane to react in a suitable solvent. The phase transfer catalyst can effectively promote the transfer of ions between the two phases, accelerate the reaction rate, and increase the yield. During operation, a suitable two-phase system is constructed, a phase transfer catalyst and reactants are added, and the reaction conditions are controlled. After the reaction is completed, the product is obtained by separation and purification.
The above synthesis methods have their own advantages and disadvantages. In practical applications, the most suitable method should be carefully selected according to specific needs and conditions.

What are the precautions for the storage and transportation of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester?

Methyl P-Tosylate (or P-Toluenesulphonic Acid Methyl Ester) is a commonly used reagent in organic synthesis. During storage and transportation, many matters need to be carefully paid attention to.
First, the storage temperature must be appropriate. This reagent is quite sensitive to temperature, and high temperature can easily cause it to decompose and deteriorate. Therefore, it should be stored in a cool place, and the temperature should be maintained between 2-8 ° C, so as to maintain its chemical stability and prolong the storage period.
Second, it is necessary to pay attention to moisture resistance. Methyl methanesulfonate is very hygroscopic, and once it is damp, it will affect its purity and reactivity. Therefore, the storage container must be well sealed, and a desiccant can be placed in the storage place to reduce the impact of environmental humidity.
Third, to prevent collisions and vibrations during transportation. Because it is a chemical reagent, violent collisions or vibrations may cause package damage, cause leakage, not only waste reagents, but also may endanger the safety of transporters and the environment.
Fourth, be sure to store and transport separately from other chemicals. Methyl methanesulfonate has a certain chemical activity. If it comes into contact with incompatible chemicals, it may cause chemical reactions and lead to danger. Such as strong oxidizing agents and strong bases, etc., should not coexist with it.
Fifth, the storage and transportation places must be clearly marked. Indicate the name, characteristics, danger warnings and other information of methyl methanesulfonate, so that personnel can quickly know its nature when handling, and take correct measures to prevent accidents.

What are the safety risks of Methyl P-Tosylate or P-Toluenesulphonic Acid Methyl Ester?

Methyl P-Tosylate (or P-Toluenesulphonic Acid Methyl Ester) is a commonly used reagent in organic chemistry, and its safety risks should not be underestimated.
This substance is irritating. If it touches the skin carelessly, it can cause redness, swelling and pain, just like the skin is scorched by fire. If it comes into contact with the eyes, it is even more harmful, or it can cause serious damage to the eyes, affecting the eyesight, like a pearl covered in dust.
Furthermore, methyl methanesulfonate is also toxic. Inhaling its volatile gas or ingesting it orally can endanger health. In the body, it is like a hidden enemy, quietly destroying the normal function of cells, interfering with physiological metabolism, long-term exposure, and even the risk of carcinogenesis. In the experimental environment or industrial production, if personnel are not properly protected and exposed to this environment for a long time, the risk of cancer will be significantly increased.
Not only that, methyl methanesulfonate is also harmful to the environment. If it is released into the environment at will, it will spread like ripples, pollute soil and water sources, and damage the balance of the ecosystem, threatening the survival of many organisms. Therefore, when using methyl methanesulfonate, it is necessary to strictly follow the safety operating procedures, take protective measures, such as wearing protective clothing, gloves, goggles, etc., and operate in a well-ventilated place to prevent harm to yourself and the environment.