Morpholine,2-[(1R)-1-[3,5-Bis(Trifluoromethyl)Phenyl]Ethoxy]-3-(4-Fluorophenyl)-,(2R,3S)-, 4-Methylbenzenesulfonate

This compound is named 2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, (2R, 3S) -, 4-methylbenzenesulfonate. Its chemical structure can be disassembled and analyzed.
First, the morpholine ring is the core structure of this compound, with the shape of a six-element nitrogen-oxygen heterocycle. At position 2 of the morpholine ring, there is a specific substituent, namely (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy. This substituent contains a benzene ring, and each of the 3rd and 5th positions of the benzene ring is connected with a trifluoromethyl group, and at the same time, it is connected to an ethoxy group, which in turn is connected to a carbon atom with the R configuration.
At position 3 of the morpholine ring, there is a 3- (4-fluorophenyl), which is another benzene ring, which contains a fluorine atom at position 4.
Furthermore, the entire main structure is connected to the ester bond of 4-methylbenzenesulfonate. The 4-methylbenzenesulfonate part has a methyl group at position 4 of the benzene ring, and the sulfonate group is bound to the main structure by an ester bond.
In summary, the structure of this compound is centered on a morpholine ring, which is connected to a specific aryl substituent and forms an ester with 4-methylbenzenesulfonate. Each part is interconnected to form a unique chemical structure.

This compound is 2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, (2R, 3S) -, 4-methylbenzenesulfonate. Its uses are manifested in many fields.
In the process of pharmaceutical research and development, this compound may be used as a key intermediate. With its unique chemical structure, it can be integrated into the drug molecular system through specific reaction steps, or endow the drug with new activity, or optimize the drug properties. For example, when developing targeted drugs for specific disease receptors, it can serve as a basic module for building active pharmacophore, helping scientists create high-affinity and high-selectivity drugs, providing powerful weapons for conquering difficult diseases.
In the field of organic synthesis, it is like a magic key. Because of its complex and unique structure, it contains a variety of active functional groups, which can participate in diverse organic reactions. Such as nucleophilic substitution, electrophilic addition, etc., as a starting material or key intermediate, it leads the synthesis route and helps synthetic chemists prepare more complex and novel organic compounds, contributing to the vigorous development of organic chemistry.
In the field of materials science, it may also make its mark. If it is introduced into the synthesis process of polymer materials, it may change the electrical, optical, thermal and other properties of the materials. For example, when preparing polymer materials with special photoelectric properties, it can be used as a functional monomer, which makes the final material show unique advantages in the fields of optoelectronic devices, such as organic Light Emitting Diodes, solar cells, etc., promoting the continuous progress of materials science and opening up new application fields.

To prepare this substance, the following steps need to be followed. First take an appropriate amount of (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethanol, mix it with a suitable base agent, and activate the alcoholic hydroxyl group. Then add a reagent containing a halogenated ethoxy group. This halogen atom is active and reacts with the activated alcoholic hydroxyl group through nucleophilic substitution to obtain (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy compound.
Take (2R, 3S) -2-hydroxy-3- (4-fluorophenyl) morpholine at times to protect the group-capped active group, leaving only the hydroxyl group that needs to be reacted. Then the hydroxyl compound and the ethoxylated compound obtained above are carried out nucleophilic substitution reaction with the help of specific solvents and catalysts to construct key carbon-oxygen bonds and obtain intermediate products.
Then, the protective group is removed to restore the activity of the specific part of the morpholine ring. The active intermediate is reacted with p-toluenesulfonyl chloride in an alkaline environment, where the sulfonyl group of p-toluenesulfonyl chloride is active, and the active part of the intermediate is nucleophilically substituted to form the sulfonate structure of the target product.
Each step of the reaction requires fine temperature control and time control. According to the reaction process and product characteristics, appropriate purification methods, such as column chromatography, recrystallization, etc., are selected to obtain high-purity 2- [ (1R) -1- [3,5-Bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine- (2R, 3S) - 4 -methylbenzenesulfonate.

Today there is a compound named Morpholine, 2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) -, (2R, 3S) -, 4-methylbenzene sulfonate. Looking at its market prospects, it is quite promising. This compound has emerged in the field of chemical and pharmaceutical research and development.
In the chemical industry, due to its unique chemical structure, it can be used as a special reaction intermediate. With the advancement of chemical technology, the demand for many new materials and high-end chemicals is increasing. The compound has a broad market prospect because it can participate in specific reactions, build special molecular structures, and meet the needs of industrial upgrading.
In terms of pharmaceutical research and development, fluorine-containing and trifluoromethyl structures often have unique biological activities. This compound structure contains such groups, or has excellent performance in drug molecular design. Modern pharmaceutical research and development focuses on precision medicine and high-efficiency and low-toxicity drugs. Its structural characteristics may help to synthesize drugs with high targeting and strong pharmacological activity, so it is favored by pharmaceutical companies and scientific research institutions.
Furthermore, with the global demand for high-end chemicals and innovative drugs rising, this compound, as a key raw material or intermediate, is expected to set sail in the market. Its future development is full of hope and opportunities, or it may become an important driving force for the development of related industries.

Preparation of this compound Morpholine, 2- [ (1R) -1- [3,5-Bis (Trifluoromethyl) Phenyl] Ethoxy] -3- (4-Fluorophenyl) -, (2R, 3S) -, 4-Methylbenzenesulfonate process, need to pay attention to many matters.
First raw material quality. Be sure to choose high-purity starting materials, 3,5-bis (trifluoromethyl) phenethane, 4-fluorophenyl compounds and 4-methylbenzenesulfonic acid and other raw materials. If there are many impurities, it will not only reduce the purity of the product, but also lead to side reactions. For example, 3,5-bis (trifluoromethyl) phenethane is impure, or contains similar structural impurities, which may compete with the main reaction during the reaction, resulting in complex and difficult separation of the product.
The reaction conditions are also critical. The temperature must be precisely controlled, and the temperature requirements at different stages are strict. In the etherification stage, if the temperature is too high, the reaction is easy to run out of control and produce too many by-products; if it is too low, the reaction is slow, time-consuming and the yield is low. Taking the etherification reaction as an example, the appropriate temperature or in a specific range, such as [X] ° C to [X] ° C, the fluctuation exceeds ± [X] ° C, which will affect the formation of the product. The pH cannot be ignored. Some steps require a specific pH environment. Peracid or peralkali may destroy the structure of the reactants or deviate the reaction direction.
Furthermore, the reaction equipment needs to be clean. Trace impurities remain or catalyze unnecessary side reactions, which affect the quality of the product. Before using the reaction vessel, it should be strictly cleaned and dried to ensure that no impurities remain from the last reaction.
Monitoring the reaction process is equally important. With the help of thin layer chromatography (TLC), high performance liquid chromatography (HPLC) and other means, real-time monitoring of the reaction progress. If abnormal reactions are found, such as reaction stagnation and increase of by-products, adjust the conditions in time. If TLC shows that an intermediate product has not been converted for a long time, it is necessary to check the temperature, catalyst and other factors.
Separation and purification steps should not be underestimated. The product contains a variety of impurities and needs to be purified by suitable methods. Using column chromatography, recrystallization and other technologies, it is crucial to choose the appropriate eluent or solvent. During recrystallization, the solvent is not selected properly, and the product may be difficult
Finally, safety protection is essential. Organic reagents are involved, which are toxic and flammable. When operating, protective equipment should be worn and carried out in a well-ventilated environment to prevent the evaporation and accumulation of organic solvents and cause safety accidents.