N-(3-Chloro-4-((3-Fluorophenyl)Methoxy)Phenyl)-6-(5-(((2-(Methylsulfonyl)Ethyl)Amino)Methyl)-2-Furanyl)-4-Quinazolinamine Bis(4-Methylbenzenesulfonate) Monohydrate

This is a rather complex organic compound. To clarify its chemical structure, its name needs to be stripped away. Its name is long and complicated and consists of many parts.
"N- (3-chloro-4- ((3-fluorophenyl) methoxy) phenyl) -6- (5- ((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide" is the main part. Analyzed from the inside out, quinazolinamine is the core structure, with a specific substituent at position 4 and a furanyl substituent at position 6, which contains complex substitutions. The part connected to the N atom has a chlorine atom at position 3 on the phenyl group, and a structure connected by 3-fluorophenyl through methoxy at position 4.
"Bis (4-methylbenzenesulfonic acid) salt, monohydrate" indicates that the compound is a salt of 4-methylbenzenesulfonic acid and contains a molecule of crystal water.
In the style of the ancient prose of "Tiangong Kaiwu", it can be described as follows: This compound is based on quinazolinamide and is derived from a complex group on the side. Its 4th and 6th positions have special substitutions, and the N-linked phenyl group is also modified by chlorine, fluorophenylmethoxy, etc. It also combines with 4-methylbenzenesulfonic acid and contains a molecule of water to form this complex chemical structure.

This medicine is called N- (3-chloro-4- ((3-fluorophenyl) methoxy) phenyl) -6- (5- (((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide bis (4 -methylbenzenesulfonic acid) monohydrate. This medicine is mostly used for the healing of intractable diseases. It has a unique pharmacology and can play an effect on the delicate parts of the human body.
Guanfu ancient people often rely on natural herbs for healing, to adjust the balance of yin, yang and qi in the human body. However, this medicine has been developed by many capable people with exquisite techniques and complicated methods. It can enter the viscera and meridians, target specific lesions, or remove stagnation and silt, or repair damage, and help the body restore health.
For patients with difficult diseases, this medicine is like a light in the dark night. In case of chronic diseases, dysfunction of the viscera, and inversion of qi and blood, the efficacy of the medicine reaches the place of illness, making yin and yang return to harmony, and qi and blood flow unimpeded. Doctors use it as a prescription, which can make the patient's symptoms gradually slow down, revive vitality, and regain a healthy state. It is actually a good prescription for the medical way to help the world.

This is an organic compound named N- (3-chloro-4- ((3-fluorophenyl) methoxy) phenyl) -6- (5 - (((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide bis (4 -methylbenzenesulfonic acid) monohydrate. Its physical properties are quite unique.
Looking at its morphology, it is mostly presented as a solid powder at room temperature and pressure. Due to the strong intermolecular force, it forms a relatively regular crystal structure. Its color is often white or off-white, which is due to the absorption and reflection characteristics of the molecular structure to visible light.
Talking about solubility, this substance has limited solubility in water. Because the molecule contains more hydrophobic groups, such as aromatic rings and long carbon chain parts, the force between water molecules is weak, so it is difficult to dissolve in water. However, in organic solvents such as dichloromethane, N, N-dimethylformamide, the solubility is improved because it is more compatible with the force between organic solvent molecules.
In terms of melting point, it has been experimentally determined to be in a specific temperature range. This temperature is the critical temperature at which a molecule obtains enough energy to overcome the lattice energy and transform from solid to liquid. It is closely related to the stability of the molecular structure and the intermolecular forces.
Stability is also an important property. Under conventional environmental conditions, if extreme conditions such as light, high temperature and strong acid and alkali are avoided, its chemical structure can be maintained relatively stable. In case of strong oxidizing agents or reducing agents, some active check points in the molecular structure may react, causing its structure to change.
In summary, this compound has specific physical properties due to its unique molecular structure. When applying in organic synthesis, drug development and other fields, the influence of these properties needs to be considered.

To prepare N- (3-chloro-4- ((3-fluorophenyl) methoxy) phenyl) -6- (5- (((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide bis (4 -methylbenzenesulfonic acid) monohydrate, the synthesis method is as follows:
First, a suitable starting material is obtained, which contains phenyl ring, furan ring and quinazoline ring-related compounds with specific substituents. In the clean reactor, according to the exact stoichiometric ratio, add a compound containing 3-chloro-4-hydroxyphenyl structure and 3-fluorobenzyl halide, add an appropriate amount of base, such as potassium carbonate, and suitable organic solvents, such as N, N-dimethylformamide. Warm to a certain temperature to promote the nucleophilic substitution reaction, so that the hydroxyl group and the halide are replaced to form 3-chloro-4- ((3-fluorophenyl) methoxy) phenyl intermediates. Then, the intermediate is mixed with a compound containing a 6-halo-4-quinazolinamine structure, a catalyst such as a palladium catalyst and a ligand are added, and a coupling reaction is carried out at a specific temperature and protected by an inert gas to construct the connection between the quinazolinamine and the phenyl group.
Then take the compound containing 5-halomethyl-2-furanyl structure, and 2 - (methylsulfonyl) ethylamine in a suitable solvent, under the catalysis of a base, carry out nucleophilic substitution to generate 5- (((2- (methylsulfonyl) ethyl) amino) methyl) -2 -furanyl intermediates.
This furanyl intermediate is reacted with the previously obtained product containing quinazolinamide under suitable conditions to complete the construction of the key skeleton.
Finally, the crude product is reacted with 4-methylbenzenesulfonic acid in a solvent, a bis (4-methylbenzenesulfonic acid) group is introduced, and then crystallization and other operations are performed to introduce crystal water to obtain the target product N- (3-chloro-4- (3-fluorophenyl) methoxy) phenyl) -6- (5- ((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide bis (4-methylbenzenesulfonic acid) monohydrate. The whole process requires fine control of reaction conditions, such as temperature, time, and material ratio, etc. After each step of the reaction, it needs to be separated and purified to ensure the purity and yield of the product.

This is a rather complex chemical named N- (3-chloro-4- ((3-fluorophenyl) methoxy) phenyl) -6- (5- (((2 - (methylsulfonyl) ethyl) amino) methyl) -2 -furyl) -4 -quinazolinamide bis (4 -methylbenzenesulfonic acid) monohydrate. There are several points to pay attention to when studying this substance.
First, its chemical structure is extremely complex, and many functional groups are connected to each other. 3-Chloro, (3-fluorophenyl) methoxy, (2 - (methylsulfonyl) ethyl) amino and other functional groups each endow the substance with unique chemical and physical properties. During synthesis, it is necessary to precisely control the reaction conditions at each step to ensure that each functional group can be connected correctly and achieve the desired structure. A slight difference in the pool may cause structural deviations of the product and affect its properties.
Second, the formation of bis (4-methylbenzenesulfonic acid) salts and monohydrates also has an important impact. Salt formation can change the solubility and stability of the compound. During the preparation process, attention should be paid to the pH, temperature and reactant ratio of the reaction environment to obtain the ideal salt-forming effect. The monohydrate indicates that when the compound crystallizes, it binds a molecule of water. The existence of water may affect its crystal form, melting point and other physical properties. When storing and using, pay attention to environmental humidity to prevent changes in moisture from affecting the properties of the substance.
Third, safety issues cannot be ignored. Compounds containing chlorine, fluorine, sulfur and other elements may be toxic, corrosive or irritating. When operating, be sure to follow strict safety procedures and fit protective equipment, such as gloves, goggles, protective clothing, etc. The experimental site needs to have good ventilation facilities to remove harmful gases that may be generated. Waste disposal should also be in compliance to avoid polluting the environment.
Fourth, in terms of analysis and identification, to confirm the structure and purity of the substance, a variety of analytical methods need to be comprehensively used, such as nuclear magnetic resonance (NMR), mass spectrometry (MS), infrared spectroscopy (IR) and elemental analysis. Each method has its own emphasis. NMR can reveal the chemical environment and connection mode of hydrogen, carbon and other atoms in the molecule; MS can determine molecular weight and molecular fragment information; IR can identify functional groups; elemental analysis determines the proportion of each element. Only a combination of methods can accurately identify.