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What is the chemical structure of N- [4- (1-cyanocyclopentyl) phenyl] -2- [ (4-pyridylmethyl) amino] nicotinamide methanesulfonate (1:1)
This is a question about the structure of organic compounds. N- [4- (1-naphthylcyclopentyl) phenyl] -2 - [ (4-pyridylmethyl) amino] quinoxaline-2-carboxylic acid (1:1), its structure is complex and delicate, let me go through it in detail.
Looking at this compound, the core structure of this compound is a quinoxaline ring, which has a conjugated system and has good stability. The second position of the quinoxaline ring is connected with a carboxyl group, which is acidic and can participate in many chemical reactions. It has a great impact on biological activity and chemical properties.
Looking at the group attached to the N atom, one end is [4- (1-naphthyl cyclopentyl) phenyl], naphthyl is a fused cyclic aromatic hydrocarbon, which has a strong conjugation effect, and cyclopentyl is connected to it, increasing its spatial structure complexity. The 4-position of phenyl has such a large group, which has a profound impact on the molecular spatial orientation and electron cloud distribution. At the other end is [ (4-pyridyl methyl) amino], pyridyl has a basic nitrogen atom, which can participate in coordination or acid-base reactions. The methyl phase plays a role in spacing and regulating electronic effects. The amino group is the key to the connection, which makes this part connected to the quinoxaline ring. In the overall view, the interaction of different groups in the structure of the compound, conjugation effect and space effect coexist, endowing it with unique chemical and physical properties, which may have potential application value in the fields of medicinal chemistry and materials science.
What are the main uses of N- [4- (1-cyanocyclopentyl) phenyl] -2- [ (4-pyridylmethyl) amino] nicotinamide methanesulfonate (1:1)
N- [4- (1-benzylcyclopentyl) phenyl] -2- [ (4-p-toluphenylethyl) amino] quinoline benzoate (1:1) is an organic compound with a wide range of uses.
In the field of pharmaceutical research and development, this compound may have unique biological activities and can act as a lead compound. By modifying and optimizing its structure, researchers are expected to create new drugs with excellent efficacy and few side effects. For example, in the development of anti-tumor drugs, it may be able to inhibit the growth and proliferation of tumor cells by virtue of a specific mechanism of action, bringing new opportunities to conquer cancer.
In the field of materials science, this compound may be used in the fields of organic Light Emitting Diode (OLED) and organic solar cells due to its unique optical and electrical properties. In OLED materials, it may emit light efficiently, improving the luminous efficiency and color expression of display devices; in organic solar cell materials, it may enhance the efficiency of light energy capture and conversion, and promote the performance of solar cells.
Furthermore, in the field of chemical research, as a special organic synthesis intermediate, it can be used to prepare organic compounds with more complex structures and unique functions. Chemists can use it to carry out various organic reactions, expand organic synthesis methodologies, enrich the variety of organic compounds, and contribute to basic research in organic chemistry.
What are the pharmacological properties of N- [4- (1-cyanocyclopentyl) phenyl] -2- [ (4-pyridylmethyl) amino] nicotinamide methanesulfonate (1:1)
The name of this drug is N- [4- (1-benzylcyclopentyl) phenyl] -2 - [ (4-methoxyphenyl) amino] quinazoline-4-formic acid (1:1), and its pharmacological properties are as follows:
This drug has a high degree of targeting. It can accurately act on specific biological targets, just like the ancient archer who made a hundred steps through the poplar, and can accurately hit the target. This is because of its unique chemical structure, which allows it to tightly bind to specific receptors or enzymes, just like tenon-mortise fit, thus exerting its drug effect, reducing interference with other unrelated cells or physiological processes, and greatly improving the accuracy and efficiency of drug action.
Furthermore, this drug has good biological activity. In the in vivo environment, it is like a dragon getting water, which can quickly and effectively participate in and regulate related physiological and biochemical reactions. It can significantly affect the signal transduction pathway of cells, just like playing a key chess game in a complex chess game, so that the growth, proliferation, differentiation and other processes of cells change in the desired direction, and then play a therapeutic role in diseases.
At the same time, this drug also has a certain stability. In the process of storage and metabolism in the body, it can maintain the relative stability of its own chemical structure and does not easily decompose or deteriorate. Like a solid fortress, it can resist the interference of external factors, ensure that the drug remains active before reaching the site of action, and ensure the continuous and stable play of the drug effect.
In addition, it also has suitable solubility and permeability. It has good solubility in body fluids, which is easy to transport in the body, just like a boat traveling in water, unobstructed; and it can smoothly penetrate the biofilm and enter the cell to play a role, which is as natural and smooth as a key unlocking, providing a strong guarantee for the drug to give full play to its pharmacological effects.
What is the preparation method of N- [4- (1-cyanocyclopentyl) phenyl] -2- [ (4-pyridylmethyl) amino] nicotinamide methanesulfonate (1:1)?
To prepare N- [4- (1 - benzylcyclohexyl) phenyl] -2 - [ (4 - methoxyphenyl) amino] benzamide (1:1), the method is as follows:
First take an appropriate amount of 4- (1 - benzylcyclohexyl) aniline, place it in a clean reaction vessel, add an appropriate amount of solvent, stir well, so that it is a homogeneous system. This solvent needs to be selected with good solubility to the reactants and no side reactions with the reaction system, such as dichloromethane, N, N - dimethylformamide and the like.
Take another 2- [ (4-methoxyphenyl) amino] benzoic acid and add it to the above reaction system. Then add an appropriate amount of condensation agent, such as dicyclohexyl carbodiimide (DCC) or 1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDC · HCl), etc. Such condensation agent can effectively promote the formation of amide bonds. At the same time, an appropriate amount of catalyst, such as 4-dimethylaminopyridine (DMAP), can be added to speed up the reaction rate.
During the reaction process, pay close attention to the reaction temperature and reaction time. Generally speaking, the temperature should be controlled between room temperature and 50 ° C, and the reaction time is about 12 to 24 hours. During this period, the reaction process can be tracked by thin layer chromatography (TLC) to determine whether the reaction is complete.
After the reaction is completed, pour the reaction solution into an appropriate amount of water and extract the product with an organic solvent. The organic solvent used for extraction, such as ethyl acetate, ether, etc., must be immiscible with water and have good solubility to the product. The organic phase is collected, dried with anhydrous sodium sulfate or magnesium sulfate, filtered to remove the desiccant, and the organic solvent is removed by vacuum distillation to obtain a crude product.
The crude product is purified by column chromatography or recrystallization. The column chromatography method can be selected from silica gel column and eluted with a suitable eluent; the recrystallization method requires the selection of solvents whose solubility of the product changes significantly with temperature, such as ethanol, acetone, etc. After multiple recrystallization, pure N - [4- (1-benzylcyclohexyl) phenyl] -2 - [ (4-methoxyphenyl) amino] benzamide (1:1) can be obtained.
N- [4- (1-cyanocyclopentyl) phenyl] -2- [ (4-pyridylmethyl) amino] nicotinamide methanesulfonate (1:1) What are the precautions in storage and transportation?
This medicine is N- [4- (1-cyclohexyl) phenyl] -2 - [ (4-methoxyphenyl) amino] benzamide (1:1). During storage and transportation, many precautions must not be ignored.
First, when storing, be sure to choose a dry, cool and well-ventilated place. This medicine is susceptible to moisture intrusion. If it is placed in a humid place or causes the medicine to become damp and deteriorate, the efficacy of the medicine will be greatly reduced. Temperature should also be properly controlled. Too high or too low can affect its chemical structure and thus affect the efficacy. Therefore, it is usually necessary to maintain within a specific temperature range to ensure the stability of the drug quality.
Second, during transportation, anti-shock and anti-collision are extremely important. The chemical properties of this medicine may be more sensitive, subject to severe vibration or impact, or cause internal structural changes. Therefore, proper protective measures should be taken during transportation, such as filling buffer materials, to ensure that the medicine is safe during transportation.
Furthermore, whether it is storage or transportation, it is necessary to strictly avoid contact with other chemical substances. Chemical reactions between different chemical substances may not only damage the structure of the medicine itself, but also generate harmful substances. Therefore, it is necessary to store and transport it separately, and keep it away from dangerous factors such as fire and heat sources to prevent accidents. Only by strictly adhering to these precautions can we ensure that the quality of this medicine is safe during storage and transportation, and its potency is not reduced, so as to play its due role in the treatment of patients.