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What is the chemical structure of (R) - [3- (3-fluoro-4-morpholinophenyl) -2-oxo-5-oxazolidyl] methylmethanesulfonate?
(R) - [3- (3-hydroxy- 4-morpholinobenzoyl) - 2-oxo-5-oxazolidyl] ethyl acetamide anhydride, which is a very complex organic compound. To clarify its chemical structure, it is necessary to analyze it according to the rules of organic chemistry and nomenclature.
Looking at the main structure, "ethylacetamide anhydride" indicates that this compound contains the basic structure of acetamide anhydride and is connected by ethyl groups. The anhydride structure is formed by the connection of two acyl groups through oxygen atoms, that is, the characteristic structure of -C (= O) -O - C (= O) -.
Look again at the part "[3- (3-hydroxy- 4-morpholinobenzoyl) - 2-oxo-5-oxazolidyl]", which is a complex substituent linked to ethylacetaminic anhydride. Where "3-hydroxy- 4-morpholinobenzoyl" means that the benzene ring has a hydroxyl group at the 3rd position and a morpholine group at the 4th position, and the benzene ring is connected to other structures through formyl (-C (= O) -). " 2-Oxo-5-oxazolidine "means that the oxazolidine ring has a carbonyl group (= O) at the 2 position.
As a whole, the structure of this compound contains a variety of cyclic structures such as benzene ring, morpholine ring, oxazolidine ring, as well as many functional groups such as carbonyl and hydroxyl groups. Each part is connected in a specific way to form this complex chemical structure. The exquisite and complex structure is exactly what" Tiangong Kaiwu "said." All matter in the world is created by exquisite creation. "In the field of organic chemistry, the uniqueness and complexity of this structure also show the wonder of the chemical world.
What are the main uses of (R) - [3- (3-fluoro-4-morpholinylphenyl) -2-oxazolidyl] methylmethanesulfonate?
(R) - [3- (3-alkyne-4-pyridylbenzyl) - 2-oxo-5-oxazolidyl] ethylacetamidazinic anhydride, which is an important intermediate in organic synthesis, is widely used in the field of medicinal chemistry. Its main uses are as follows:
First, it is used in drug research and development. Many new drugs rely on it as a starting material. Due to its unique chemical structure, it can accurately construct the molecular skeleton of drug activity through a series of chemical reactions. For example, in the research and development of anti-tumor drugs, compounds with specific targeting properties can be synthesized by modifying and modifying their structures. After screening by pharmacological experiments, new anti-cancer drugs with high efficiency and low toxicity are expected to be obtained.
Second, it plays a significant role in the study of organic synthesis reactions. It can be used as a key substrate to explore novel reaction pathways and reaction mechanisms. Chemists use it to participate in catalytic reactions, cyclization reactions, etc., to expand the boundaries of organic synthesis chemistry, providing new ideas and new methods for the synthesis of complex organic molecules.
Third, it has emerged in the field of materials science. After specific modifications, materials can be given special properties. Such as the introduction of specific functional groups, the material has optical, electrical, magnetic and other response characteristics, and is used in the preparation of smart materials, sensor materials, etc.
In short, (R) - [3- (3-alkyne-4-pyridyl benzyl) - 2-oxo-5-oxazolidyl] ethyl acetamidazine anhydride plays a key role in many fields due to its unique structure and reactivity, promoting related scientific research and technological development.
What is the synthesis method of (R) - [3- (3-fluoro-4-morpholinophenyl) -2-oxo-5-oxazolidyl] methylmethanesulfonate?
The synthesis of (R) - [3 - (3 - deuterium - 4 - morpholinyl benzyl) - 2 - oxo - 5 - oxazolidyl] ethyl acetamide is an important subject in the field of organic chemistry. To synthesize this substance, the following ancient methods can be followed.
Take an appropriate amount of 3- (3 - deuterium - 4 - morpholinyl benzyl) - 2 - oxazolidine and place it in a clean reactor. The kettle needs to be roasted over a charcoal fire to remove its moisture and impurities. After cooling the kettle, slowly inject an appropriate amount of ethyl ethanol into the glass funnel. The ethyl alcohol ester needs to be distilled multiple times to ensure purity and no impurities.
Then, add a little special catalyst to the kettle. This catalyst is made of several rare medicinal stones, which are calcined and ground according to a specific heat and time. After adding the catalyst, simmer slowly over a slow fire. The fire needs to be uniform and stable, not large or small. During this period, stir with bamboo chopsticks from time to time to fully blend the contents of the kettle.
After several hours of reaction, the color of the liquid in the kettle can be seen gradually changing, which is a sign of the reaction. When the color is stable, stop heating and let the contents of the kettle cool naturally. Then, the impurities are filtered out with a fine filter screen to obtain a clear liquid.
The liquid is then moved into another refined container, and the excess solvent is removed by low temperature distillation. During distillation, pay close attention to the heat and temperature, and do not make the temperature too high to avoid damage to the product. After this operation, a crude (R) - [3- (3-deuterium-4-morpholinyl benzyl) -2-oxazolidyl] ethylacetamide can be obtained.
Finally, purified by recrystallization. Take an appropriate amount of good solvent, dissolve the crude product into it, heat and stir to fully dissolve. When the solution cools, the crystals can be seen slowly precipitating. Rinse the crystals several times with cold water, and then dry at low temperature to obtain pure (R) - [3- (3-deuterium-4-morpholinyl benzyl) - 2-oxo-5-oxazolidyl] ethylacetamide.
What are the physicochemical properties of (R) - [3- (3-fluoro-4-morpholinylphenyl) -2-oxazolidyl] methylmethanesulfonate?
(R) - [3- (3-ene-4-morpholinylbenzyl) - 2-oxo-5-oxazolidyl] ethylacetamidoxime ester is an organic compound, and its physical and chemical properties are as follows:
** 1. Physical properties **
1. ** Appearance properties **: Due to differences in specific chemical structure details, the appearance may be white to light yellow crystalline powder, with fine texture, similar to fine frost powder, or under light. This appearance characteristic is similar to many organic synthesis intermediates with similar structures, and is quite common in solid organic compounds.
2. ** Melting point and boiling point **: The melting point is closely related to the intermolecular force. There are various interactions in the molecule of this compound, such as hydrogen bonds, van der Waals forces, etc. The combined effect causes its melting point to be within a certain range. However, the exact value needs to be determined experimentally and accurately. The boiling point is also affected by the intermolecular force and structure. Due to the relatively large and complex structure of the molecule, its boiling point may be higher, and a higher temperature is required to allow the molecule to obtain enough energy to overcome the intermolecular force and vaporize.
3. ** Solubility **: According to the principle of similarity miscibility, in view of its molecular structure containing polar groups, such as carbonyl, nitrogen heterocycles, etc., in polar organic solvents, such as ethanol and acetone, it may have a certain solubility. It is like a salt dissolving in water, and the solute and the solvent form an However, in non-polar solvents, such as n-hexane, the solubility is poor, because the molecular polarity is different from that of non-polar solvents, and it is difficult to miscible with each other.
** Second, chemical properties **
1. ** Stability **: Under conventional conditions, the structure is relatively stable, and the chemical bonds between the atoms in the molecule are relatively firm. However, under extreme conditions such as high temperature, strong acid, and strong base, the chemical bonds may be destroyed. For example, when the temperature is high, some of the weak bonds in the molecule may break, triggering decomposition reactions; under strong acid, strong base environment, or chemical reaction with acid and base, changing the molecular structure.
2. ** Reactive activity **: The alkenyl group in the molecule is unsaturated and can undergo addition reactions, just like the addition of olefins and halogens, the alkenyl double bond is opened and bound to other atoms or groups. In addition, the 2-oxo-5-oxazolidinyl part may participate in cyclization, ring opening and other reactions, providing a variety of possibilities for organic synthesis, which can react with different reagents to construct complex organic structures.
What are the applications of (R) - [3- (3-fluoro-4-morpholinylphenyl) -2-oxazolidyl] methylmethanesulfonate in the field of medicine?
(R) - [3 - (3 - hydroxyl - 4 - morpholinyl benzyl) - 2 - oxo - 5 - oxazolidyl] ethylacetamide, this compound is widely used in the field of medicine.
It is of great significance in the research and development of anti-infective drugs. Because of its special morpholinyl benzyl, oxazolidyl and other parts in its structure, it has a significant inhibitory effect on specific bacteria. For example, in the development of therapeutic drugs for infectious diseases caused by some Gram-positive and negative bacteria, it is possible to modify the structure of this compound to enhance the binding force between the drug and the key targets of the bacteria, destroy the cell wall, cell membrane or interfere with the nucleic acid synthesis of the bacteria, and then effectively inhibit the growth and reproduction of the bacteria, providing a new way for the treatment of infections in the respiratory tract, digestive tract and other parts.
is also involved in the research of anti-tumor drugs. Some studies have shown that some structural fragments of the compound may affect the signaling pathway of tumor cells, hinder the proliferation of tumor cells and induce their apoptosis. Based on it, researchers have designed and synthesized a series of derivatives to explore the inhibitory activity of different tumor cell lines, hoping to develop high-efficiency and low-toxicity anti-tumor drugs, which will bring new hope for cancer treatment.
In the development of drugs for the treatment of neurological diseases, due to its special chemical structure, it can cross the blood-brain barrier and regulate the release of neurotransmitters or receptor activity. For example, for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, it is expected to develop drugs that can improve neurological function and delay the progression of diseases, bringing good news to patients with neurological diseases.