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What is the chemical structure of (S) -2- (4- (Piperidin-3-Yl) Phenyl) -2H-Indazole-7-Carboxamide 4-Methylbenzenesulfonate Hydrate?
(The chemical structure of this compound is described below) This compound is named (S) -2- (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide 4-methylbenzene sulfonate, a hydrate. Its chemical structure consists of an indazole ring linked to a phenyl group containing piperidin-3-group substitution at position 2 and a formamide group at position 7. Where (S) represents a specific chiral configuration, indicating a specific arrangement of its spatial structure. 4-Methylbenzene sulfonate binds to it as a counterion, interacting with it through ionic bonds. In addition, there is a hydrate, that is, water molecules bind to the compound in a specific ratio. The formation of this hydrate, or due to the interaction of molecules, such as hydrogen bonds, the water molecules are embedded in the structure of the compound. In this way, the parts are combined to form (S) -2- (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide-4-methylbenzene sulfonate, the unique chemical structure of the hydrate.
What are the main uses of (S) -2- (4- (Piperidin-3-Yl) Phenyl) -2H-Indazole-7-Carboxamide 4-Methylbenzenesulfonate Hydrate?
(This drug) is called (S) -2- (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide 4-methylbenzenesulfonate monohydrate, and its main uses are very wide. In medical medicine, it is often used as a key ingredient in pharmaceutical research and development. Doctors explore this drug, hoping that it can make a difference in the treatment of diseases.
Because of the wide variety of diseases, the symptoms are complex and changeable, and various diseases urgently need good medicine to solve. After research, this drug may have great potential for the treatment of specific diseases. For some chronic diseases, patients are suffering from long-term illness and are in great pain. Doctors then look to this drug to see if it can relieve symptoms and promote physical recovery.
In the field of pharmacological research, this drug is also a key research object. Scholars want to understand its mechanism of action, investigate its effects on human physiological processes, and explore its interactions with various biomolecules in the body, hoping to open up new frontiers of medical cognition and pave the way for future drug creation and therapy improvement.
Furthermore, in the process of clinical trials, this drug plays an important role. Doctors follow scientific methods to carefully observe its efficacy and safety, in order to determine its feasibility in clinical application, for the well-being of patients, so that if this drug is indeed effective, it can be administered to patients as soon as possible to help them get rid of their suffering.
How safe is (S) -2- (4- (Piperidin-3-Yl) Phenyl) -2H-Indazole-7-Carboxamide 4-Methylbenzenesulfonate Hydrate?
(The following is explained in the style of ancient Chinese)
This " (S) -2- (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide-4-methylbenzene sulfonate, hydrate" is related to safety and needs to be carefully investigated.
This substance is in the field of chemistry and has a specific structure. Its safety properties are the first to be involved in toxicity. Although it has not been personally tested, it is common sense that organically synthesized substances mostly contain chemically active groups, or are potentially toxic. If ingested inadvertently or absorbed through the skin, it may damage the function of the viscera. In the digestive system, or cause gastrointestinal diseases, such as abdominal pain, diarrhea; in the blood system, or disturb blood circulation, causing blood cell mutation.
Furthermore, the stability of this substance is also critical. The state of hydrate may change due to the change of temperature and humidity of the environment. Under high temperature, or amorphous water, cause structural changes, chemical activity increases sharply, and then cause unexpected reactions. In case of open flame, organic components may be flammable, meet with oxidants, or cause violent changes, endangering the surrounding.
And its impact on the environment cannot be ignored. If it flows into water and soil, with its complex chemical structure, or difficult to degrade, it accumulates in the ecology, harming fish, shrimp, insects and ants, and disrupting the ecological balance.
Therefore, those who handle this thing must strictly abide by safety procedures. When handling, prepare protective equipment, such as gloves and masks, to avoid contact with the body, skin and eyes. Do it in a well-ventilated place to prevent its volatile gas from entering the body. Store it properly after use, and dispose of the remaining materials according to regulations to ensure people's safety and tranquility.
What is the market outlook for (S) -2- (4- (Piperidin-3-Yl) Phenyl) -2H-Indazole-7-Carboxamide 4-Methylbenzenesulfonate Hydrate?
Nowadays, there are (S) -2 - (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide-4-methylbenzene sulfonate hydrates, which are available in the market as follows. This substance is a key intermediate involved in the field of pharmaceutical research and development in the present world. However, in the market, it is not an uncommon product. Due to the complex and delicate synthesis process, it requires a variety of special reagents and precise reaction conditions, resulting in a limited number of outputs.
On the market, this compound often appears in specific scientific research institutions and pharmaceutical companies, and is not a common commodity known to the public. Its transactions are mostly in the professional chemical raw material market or specific scientific research material trading platforms, and are mostly related to new drug research and development projects. Buyers are often pharmaceutical companies and scientific research teams specializing in innovative drug research and development. In order to obtain this key material, they will not hesitate to spend a lot of money and effort.
Due to the difficulty of synthesis and R & D requests, its price is not cheap, and it is often circulated in specific market circles at a high price. The quality control in the market is also extremely strict, and it needs to be tested repeatedly to ensure that it meets specific purity and Quality Standards before it can be used in the high-end pharmaceutical research and development process. Therefore, (S) -2 - (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide-4-methylbenzene sulfonate hydrate is active in the field of professional pharmaceutical research and development with scarcity and high price in the market.
What is the preparation method of (S) -2- (4- (Piperidin-3-Yl) Phenyl) -2H-Indazole-7-Carboxamide 4-Methylbenzenesulfonate Hydrate?
The preparation method of (S) -2 - (4- (piperidine-3-yl) phenyl) -2H-indazole-7-formamide-4-methylbenzene sulfonate hydrate is a key technology in organic synthesis. To prepare this substance, the first focus should be on the synthesis of key intermediates.
Take 4- (piperidine-3-yl) aniline first, which is an important starting material. Mask its amino group with an appropriate protective group to prevent it from overreacting in subsequent reactions. A protective group such as acetyl is often selected and introduced by acylation reaction under mild conditions. Pyridine is used as a base, and the product of amino protection can be obtained in a suitable solvent such as dichloromethane at room temperature or slightly heated.
Then, the protective product is reacted with a suitable indazole-7-carboxylic acid derivative. It can be catalyzed by condensing agents such as dicyclohexyl carbodiimide (DCC) and 4-dimethylaminopyridine (DMAP), in organic solvents such as tetrahydrofuran, fully stirred to form key amide bonds, to obtain (S) -2 - (4- (protected piperidine-3-yl) phenyl) -2H-indazole-7-formamide intermediates.
Then remove the amino protecting group under mild conditions, such as dilute acid solution, react at low temperature to restore the amino activity. At this time, (S) -2 - (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide is obtained.
Finally, the product is reacted with 4-methylbenzenesulfonic acid in a suitable solvent such as ethanol, stirred and dissolved according to an appropriate stoichiometric ratio, heated and refluxed or left at room temperature for a period of time to form the target (S) -2 - (4- (piperidin-3-yl) phenyl) -2H-indazole-7-formamide 4-methylbenzenesulfonate. If the hydrate is required, the solvent volatilization rate and environmental humidity can be controlled during the crystallization process, so that water molecules can be properly introduced during the crystallization process to finally obtain the desired hydrate product. The whole preparation process requires fine control of reaction conditions, focusing on the purification and characterization of intermediates to ensure the purity and yield of the product.