(S)-Alpha-(2-Chlorophenyl)-6,7-Dihydrothieno[3,2-C]Pyridine-5(4H)-Acetic Acid Methyl Ester (1R)-7,7-Dimethyl-2-Oxobicyclo[2.2.1]Heptane-1-Methanesulfonate

(2S) -alpha- (2-methoxyphenyl) -6,7-dihydropyrazolo [3,2-c] pyridine-5 (4H) -methyl acetate (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-carboxylate benzyl ester, both of which are organic compounds.
(2S) -alpha- (2-methoxyphenyl) -6,7-dihydropyrazolo [3,2-c] pyridine-5 (4H) -methyl acetate, in which the pyridine ring is fused to the pyrazole ring, with a methyl acetate group attached at the 5th position and a 2-methoxyphenyl group attached at the α position, and the compound has a 2S configuration. In this structure, the fused part of pyridine and pyrazole provides certain aromaticity and basicity, methoxyphenyl can affect the electron cloud distribution and steric hindrance of the compound, and the methyl acetate group gives it a certain estrophilicity and reactivity check point. It can be used as a key intermediate in the field of organic synthesis and pharmaceutical chemistry to participate in the construction of more complex structures, or used for modification to adjust the physicochemical properties of the compound.
(1R) -7,7-dimethyl-2-oxobicyclic [2.2.1] heptane-1-carboxylate benzyl ester, the structure uses dicyclic [2.2.1] heptane as the parent nucleus, the 2-position is carbonyl, and the 1-position is connected to the benzyl formate group, and has the 1R configuration. The bicyclic structure endows it with specific rigidity and spatial shape, dimethyl increases the hydrophobicity and steric hindrance of the molecule, carbonyl has electrophilicity, and reactions such as nucleophilic addition can occur. Benzyl formate groups can be deprotected under appropriate conditions or participate in further esterification, substitution and other reactions. They are often used in organic synthesis to construct compounds with specific structures and activities, and have potential applications in the fields of total synthesis of drugs and natural products.

(This medicine) (S) -alpha - (2-fluorobenzyl) -6,7-dihydropyrazolo [3,2-C] pyridine-5 (4H) -methyl acetate (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-methoxyformamide, has many wonderful pharmacological effects. It can enter the human meridians, regulate the flow of qi and blood. In the nervous system, it can soothe the the soul, make the mind clear, relieve anxiety and disturbance, and help the mind and mind to sleep peacefully. For the circulatory system, such as a smooth river, make the blood smooth, stabilize blood pressure, and protect the normal beating of the heart. In the immune system, it is like a strong barrier, strengthening the body's ability to resist external evil and reducing the suffering of patients. This medicine has been delicately processed, interlocking with the human body's biochemical mechanism with a unique structure, accurately exerting its effect, removing diseases and strengthening the body. It is actually a good agent for doctors to treat diseases, bringing hope for health to many patients.

(S) -alpha- (2-chlorobenzyl) -6,7-dihydroindolo [3,2-c] pyridine-5 (4H) -ethyl acetate, and (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-formylsalicylate for temporary application, in "Tiangong Kaiji", although there is no exact report, but it is deduced from ancient pharmaceutical and technological ideas, or there are several uses.
View of ancient pharmacy, often heavy on the processing and compatibility of drugs. Either after processing, their properties or changes to be suitable for medicinal use. For example, in "Tiangong Kaiwu", there is also attention to the preparation of various medicines, or fry, or boil, or sun, to make the best of their properties. These two substances may be processed to relieve human discomfort. (S) -alpha - (2-chlorobenzyl) -6,7-dihydroindolo [3,2 - c] pyridine-5 (4H) -ethyl acetate, or with the effect of regulating qi and blood, (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-formylsalicylate, or can pass through the meridians. The two are compatible, or can slow down the symptoms of poor qi and blood and blocked meridians.
Furthermore, in the ancient craftsmanship, there was a method of making things with things and taking their essence. These two things may be extracted through exquisite craftsmanship to extract effective qualities for making ointments and pills. For example, in "Tiangong Kaiwu", the preparation of ointment pills pays attention to proportion and heat. Using this method, it may be possible to make medicines suitable for trauma, bruising, or internal pain. However, it is all speculation. The ancient records did not detail these two. Today, it is deduced by thinking, or it may be used in such a temporary way.

(The description of chemical substances in this paragraph is extremely professional and complex. The following attempt is to answer in the classical Chinese style of "Tiangong Kaiwu")
Fu (2S ） -α -（ 2-chlorobenzyl) -6,7-dihydroindolo [3,2-c] pyridine-5 (4H) -ethyl acetate, and (1R) -7,7-dimethyl-2-oxobicyclic [2.2.1] heptane-1-benzyl carboxylate Both, which are in chemical reactions, or there are many unsuitable reverse reactions. The structure of the two is exquisite and complex, and the breaking and recombination of chemical bonds requires specific conditions and media.
Such as the temperature and humidity of the reaction environment, the presence or absence of catalysts and the type of catalyst, can cause the reaction to go astray. If the temperature and humidity are not suitable, the reaction rate may be slowed or even stagnant. The catalyst is not suitable, and it is difficult to start the bond change of the reaction. And in the structure of these two substances, the functional groups are constrained by each other, and the effect of steric hindrance is significant. ( 2 S ） -α -（ 2-chlorobenzyl) -6,7-dihydroindolo [3,2-c] pyridine-5 (4H) -ethyl acetate of benzyl and pyridine ring, and (1R) -7,7 -dimethyl-2-oxobicyclic [2.2.1] heptane-1-benzyl formate of the bicyclic structure and benzyl formate group, when reacting with each other, spatial arrangement or blocking, so that the reactant molecules difficult to achieve effective collision orientation, and therefore prone to unsuitable reverse reaction, resulting in impure products, yield difficult to rise, it is a difficult problem in chemical synthesis.

To prepare (S) -alpha - (2-fluorobenzyl) -6,7-dihydroindolo [3,2-C] pyridine-5 (4H) -ethyl acetate and (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-methoxycarboxylate, the method is as follows:
First take (S) -alpha - (2-fluorobenzyl) -6,7-dihydroindolo [3,2-C] pyridine-5 (4H) -acetic acid, place it in a clean reaction vessel, add an appropriate amount of ethanol and catalyst amount of concentrated sulfuric acid, heat and reflux, so that esterification reaction occurs. During close monitoring of the reaction process, until the reaction reaches the desired level, the reaction liquid is cooled, neutralized with an appropriate amount of saturated sodium carbonate solution, the organic phase is separated, dried with anhydrous sodium sulfate, filtered and distilled under reduced pressure to obtain (S) -alpha - (2-fluorobenzyl) -6,7-dihydroindolo [3,2-C] pyridine-5 (4H) -ethyl acetate.
As for the preparation of (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-methoxycarboxylate, first use (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-carboxylic acid as the starting material, dissolve it in a suitable organic solvent, add potassium carbonate and other bases, stir well, slowly add chloromethyl methyl ether dropwise, control the reaction temperature and dropwise speed. After the dropwise addition is completed, the reaction continues for a certain period of time. At the end of the reaction, add water to quench, extract and separate the organic phase, and purify it by column chromatography to obtain (1R) -7,7-dimethyl-2-oxobicyclo [2.2.1] heptane-1-methoxycarboxylate. During operation, it is necessary to pay attention to the precise control of each reaction condition to ensure the smooth progress of the reaction and improve the yield and purity of the product.