What is the main use of Sodium 1 - Heptanesulfonate?
Sodium + 1 - Heptanesulfonate is sodium heptane sulfonate, and its main uses are as follows:
In liquid chromatography, sodium heptane sulfonate is a class of ion pair reagents with remarkable functions. When separating and analyzing organic acids, bases and ionic compounds, the effect is extraordinary. For example, in the field of pharmaceutical analysis, many drug components have ionic groups. With the help of sodium heptane sulfonate, the interaction between these ionic drugs and the stationary phase can be promoted to a better state, thereby improving the efficiency and effect of separation, making the peak shape more ideal, and achieving accurate determination of each component in the drug.
In the field of chemical synthesis, sodium heptane sulfonate is also useful. Sometimes it can act as a phase transfer catalyst to help the reaction proceed smoothly between different phases, promoting the reaction to occur more easily and improving the yield of the reaction. For example, in some reactions involving the organic phase and the aqueous phase, sodium heptane sulfonate can effectively promote the mass transfer of the reactants between the two phases, making the reaction efficient.
In addition, in the related applications of surfactants, sodium heptane sulfonate can affect the surface properties of the solution due to its unique molecular structure. It can change the surface tension and other properties of the solution, and plays an important role in some systems that need to regulate the surface properties. For example, in the preparation process of some emulsion systems, it helps to stabilize the formation of emulsions.
Sodium 1 - Heptanesulfonate in storage
Sodium + 1 - Heptanesulfonate is sodium 1 - heptane sulfonate. When storing it, pay attention to the following things:
First, it needs to be placed in a cool place. This product is afraid of heat, and if it is placed in a high temperature, it may cause its chemical properties to change. High temperature can easily promote its chemical reaction and damage its purity and quality. As "Tiangong Kaiwu" said, all kinds of things have their suitable places to exist. The same is true for this product. A cool place can keep its stability.
Second, it must be placed in a dry place. Sodium 1 - heptane sulfonate is easy to absorb moisture. Once it is damp, it may agglomerate and affect its chemical activity. Like a natural creation, when exposed to water and wet gas, there are many changes. After this product absorbs moisture or is insoluble in subsequent use, or when it participates in the reaction, the result is deviated.
Third, it should be sealed and stored. In the air, there are many components, such as oxygen, water vapor and other gases. 1 - Sodium heptane sulfonate If exposed to the air, or reacts with some of the components. Sealed, it can be cut off from contact with the outside air and retain its original properties, just like the method of properly sealing things in Tiangong Kaiwu, so that it is not disturbed by the outside world.
Fourth, do not store with incompatible substances. Such as strong oxidants, strong acids, strong bases, etc., should not be stored in the same place as sodium 1-heptane sulfonate. Due to contact with it, or cause violent chemical reactions, even there is a risk of safety, such as explosion, fire, etc. When it depends on the nature of things, it is a surefire policy to classify and store them properly, which is also in line with the concept of reasonable arrangement of different things in "Tiangong Kaiwu".
What are the chemical properties of Sodium 1 - Heptanesulfonate
Sodium (Sodium) and sodium n-heptane sulfonate (Sodium 1 - Heptanesulfonate) are not the same substance. In this paper, the chemical properties of sodium n-heptane sulfonate have various characteristics.
Sodium n-heptane sulfonate is an ionic compound, which can be well dissolved in water. Due to its ionic structure, it can ionize sodium ions and heptane sulfonate ions. This property makes the compound exhibit certain electrical conductivity in solution.
Furthermore, heptane sulfonate has a long carbon chain, giving the compound a certain surface activity. In certain systems, it can reduce the surface tension, causing it to be arranged in an orderly manner at the interface. This property may be useful in processes such as emulsification and dispersion.
In addition, sodium n-heptane sulfonate has a certain hydrophilicity due to its sulfonic acid group, and the long-chain alkane part is hydrophobic. This dual property allows it to participate in many chemical processes involving hydrophilic-hydrophobic interactions. And the substance is relatively stable, and under common conditions, it is not easy to spontaneously decompose. In the field of organic synthesis, it is often used as an ion pair reagent to assist in achieving specific reactions and improve the separation effect; in analytical chemistry, it is also often used in liquid chromatography analysis to optimize separation conditions and improve the separation efficiency of specific substances.
What is the recommended dose of Sodium 1 - Heptanesulfonate as an additive?
Sodium + 1 - Heptanesulfonate, or sodium heptane sulfonate, is a commonly used additive in liquid chromatography, which can improve the separation effect of ionic or ionizable compounds. The determination of its dosage requires a combination of many factors.
Looking at the mobile phase system, if it is reversed-phase liquid chromatography, the dosage of sodium heptane sulfonate is usually low, generally between 0.01% and 0.1% (mass-to-volume ratio). If the mobile phase is an aqueous-organic phase mixed system, when the proportion of organic phase is high, the solubility of sodium heptane sulfonate will decrease, and the dosage should be reduced; when the proportion of organic phase is low and the aqueous phase is the main one, the dosage can be appropriately increased.
Then look at the characteristics of the sample. If the degree of ionization of the sample is high and the concentration is large, the amount of sodium heptane sulfonate may need to be increased in order to obtain the best separation; if the degree of ionization of the sample is low and the concentration is dilute, a small amount of sodium heptane sulfonate can meet the separation requirements.
In terms of column properties, the tolerance and retention behavior of sodium heptane sulfonate are different for columns of different fillers and specifications. Some columns are not suitable for high concentrations of ionic additives. At this time, the amount of sodium heptane sulfonate should be strictly controlled.
Generally speaking, the initial experiment is 0.05% (mass to volume ratio), that is, 0.05 g of sodium heptane sulfonate per 100 mL mobile phase. Subsequent fine-tuning according to the separation results. If the separation is not good, the dosage can be slightly increased; if there are problems such as abnormal peak shape, the dosage may need to be reduced. In this way, through careful debugging, the dosage of sodium heptane sulfonate suitable for specific analysis can be obtained.
Sodium 1 - Heptanesulfonate Quality Standards
Sodium 1 - Heptanesulfonate, that is, sodium 1 - heptane sulfonate, the common Quality Standards are as follows.
Its content should be not less than 99.0% according to the excellent purity standard; the analytical purity standard should be not less than 98.0%. The appearance should be a white crystalline powder without visible impurities. In terms of water solubility, it should be highly soluble in water to form a clear and transparent solution. For pH value, in the specified concentration of aqueous solution, it usually needs to be within a certain range, such as 5.0 - 8.0.
Furthermore, the impurity limit. The chloride content should be extremely low, under the excellent purity standard, it should not exceed 0.005%; the analytical purity standard should not exceed 0.01%. Sulfate content, excellent grade purity shall not exceed 0.01%, analytical purity shall not exceed 0.02%. Heavy metal (as Pb) content, excellent grade purity shall be less than 0.0005%, analytical purity shall be less than 0.001%.
Incinerating residue, excellent grade purity shall not exceed 0.1%, analytical purity shall not exceed 0.2%. These Quality Standards are crucial when applying this reagent in many fields such as chemical analysis and drug development, and are related to the accuracy and reliability of experimental results.