Sodium 2'-(Dicyclohexylphosphino)-2,6-Dimethoxy-[1,1'-Biphenyl]-3-Sulfonate Hydrate

Sodium 2 '- (Dicyclohexylphosphino) -2,6-Dimethoxy- [1,1' -Biphenyl] -3-Sulfonate Hydrate, the Chinese name is often called 2 '- (dicyclohexylphosphonyl) -2,6-dimethoxyl- [1,1' -biphenyl] -3-sulfonate sodium hydrate, which is widely used in the field of organic synthesis.
It plays a significant role in catalytic reactions. It can be used as a ligand in many transition metal catalytic reactions. Taking the coupling reaction catalyzed by palladium as an example, this substance combines with palladium metal with its unique phosphorus atom to form a stable complex. This complex can enhance the activity and selectivity of palladium catalysts, promote milder reaction conditions, and improve the reaction yield. For example, in the Suzuki coupling reaction of aryl halide and alkenyl boronic acid, the use of this ligand can make the reaction proceed efficiently at a relatively low temperature, and accurately construct carbon-carbon bonds, which is of great significance for the synthesis of complex organic molecules.
In the field of medicinal chemistry, its application should not be underestimated. In the process of building the key structures of drug molecules, the catalytic reaction participated by this ligand can achieve the precise construction of specific chemical bonds. Through precise control of the reaction, the synthesis of drug intermediates with specific activities can help the development and production of new drugs, providing important support for the development of medicinal chemistry.
In the field of materials science, when it comes to the synthesis of organic semiconductor materials, the molecular structure and properties of the materials can be effectively regulated by the catalytic reaction participated by this substance. For example, the synthesis of organic semiconductors with specific conjugated structures lays the foundation for the performance optimization of organic electronic devices, and has potential applications in the fields of organic Light Emitting Diodes, organic solar cells, etc.

Sodium - (dicyclohexylphosphine) - 2,6 - dimethoxy - [1,1 '-biphenyl] - 3 - sulfonate, hydrate, the chemical properties of this substance are particularly important. Its properties are multi-terminal, let me tell you one by one.
This substance is relatively stable at room temperature, and it may decompose when it encounters hot topics. When decomposing, harmful gases may be generated, so when disposing and storing, it is necessary to pay attention to temperature control. Its solubility in water is considerable, and it can blend with water to form a uniform solution. This property makes it a participant in a variety of chemical processes in a water-soluble system.
Its chemical activity is closely related to the surrounding chemical environment. In an acidic environment, specific chemical reactions may occur, and the ionic state may be changed due to the action of protons, resulting in changes in its chemical properties. In an alkaline environment, it also has a different reaction situation.
Furthermore, its interaction with metal ions is also characteristic. Or it can complex with certain metal ions to form stable complexes. This complexation may have potential application value in catalytic reactions and other fields. Due to its structure containing specific atomic groups such as phosphorus and sulfur, this substance is suitable for organic synthesis, or can be used as a unique reagent to assist in the formation and breakage of certain chemical bonds, demonstrating its unique effectiveness in chemical synthesis processes.

Those who hide this medicine need to be careful about everything. This is Sodium - (di-cyclohexylphosphine) -2,6-dimethoxyl- [1,1 '-biphenyl] -3-sulfonate sodium hydrate, which is delicate in nature and has strict requirements for Tibetan methods.
First, it should be placed in a dry place. The damp gas is easy to invade its essence, and the properties of the medicine are mutated, and the efficacy of the medicine is impaired. If you are in a place where the water vapor is diffuse, it is not advisable on the banks of rivers, on the sides of lakes and marshes, or in cellars. When looking for a well-ventilated, dry place without moisture, such as on a high pavilion, away from water sources and wet things.
Second, avoid direct sunlight. The intensity of sunlight can break the structure of its molecules and make the medicine ineffective. Do not expose to the hot sun, or place it near a bright window, and never store it in a place with direct sunlight. It can be hidden in a cabinet, or covered with a black cloth to block its light and protect its quality.
Third, control its temperature. Extreme heat and cold are not suitable. High temperature can promote its chemical reaction and cause the decomposition of drugs; low temperature can freeze it and damage its structure. It is best to keep it at a gentle place at room temperature, between 15 and 25 degrees Celsius.
Fourth, isolate all objects. Do not co-store with acid and alkali substances to prevent them from converging with them and damaging their nature. Also do not coexist with odorous substances, lest they smell together and damage the purity of the medicine.
Those who hide this medicine, if they follow these rules, can ensure the quality of the medicine, prolong its use, and achieve complete healing.

To prepare Sodium- (2 '- (Dicyclohexylphosphino) -2,6-Dimethoxy- [1,1' -Biphenyl] -3-Sulfonate) Hydrate, the method is as follows:
The first raw material needs to take an appropriate amount of 2,6-dimethoxy-3-bromobiphenyl, dicyclohexylphosphine lithium, etc. In a clean and dry reaction bottle, an inert gas such as nitrogen is used to remove the air in it to maintain the oxygen-free reaction environment.
Dissolve 2,6-dimethoxy-3-bromobiphenyl in a suitable organic solvent, such as anhydrous tetrahydrofuran, and stir to disperse it uniformly. The tetrahydrofuran solution of lithium dicyclohexylphosphine is slowly added dropwise, and the temperature is controlled at a low temperature during dropwise addition, such as -78 ° C, to prevent side reactions from occurring. After dropping, gradually raise the temperature to room temperature, and continue to stir the reaction for several times to make the reaction sufficient.
After the reaction is completed, quench the unreacted raw materials with appropriate reagents. After that, the reaction mixture is separated and purified. First, the organic solvent is removed by a rotary evaporator to obtain a crude product. After column chromatography, a suitable eluent is selected, such as a mixture of petroleum ether and ethyl acetate, which is prepared in proportion to achieve a good separation effect, and a pure 2 '- (dicyclohexylphosphino) -2,6 -dimethoxyl- [1,1' -biphenyl] -3 -sulfonic acid is obtained.
Finally, the sulfonic acid product is reacted with an appropriate amount of sodium hydroxide solution to adjust to a suitable pH value. After the reaction is sufficient, concentrate and crystallize to obtain Sodium- (2 '- (Dicyclohexylphosphino) -2,6-Dimethoxy- [1,1' -Biphenyl] -3-Sulfonate) Hydrate, which is further purified by recrystallization to obtain a high-purity target product.

Sodium- (Dicyclohexylphosphino) -2,6-Dimethoxy- [1,1 '-Biphenyl] -3-Sulfonate Hydrate, this is a chemical substance. To know its market price, it is difficult to answer directly. Because of the market price pattern, it often changes with many factors.
Looking at the price status of chemical products in the past, the abundance of raw material sources is the key end. If the raw material of this substance is easy to collect and the output is sufficient, its price may be stable and low; conversely, if the raw material is scarce and requires a lot of manpower and material resources to obtain, the cost will rise, and the price will rise.
Furthermore, the difficulty of the preparation process also affects its price. If the preparation process is complicated, special equipment, superb skills are required, and there are many intermediate links, a lot of resources need to be invested in quality control and purification, and the price will be high; if the process is relatively simple, large-scale production can be carried out, and the cost can be controlled, the price is expected to be close to the people.
The situation of market supply and demand is also an important factor in determining the price. If this substance is in a certain period of time, due to the surge in demand from emerging industries, the supply cannot keep up for a while, and the price will rise; on the contrary, if the market demand is weak and the supply is excessive, the merchant may reduce the price in order to destock.
In addition, the difference between regions and brands will also make the price different. In prosperous cities and places with convenient transportation, prices may be different from those in remote areas due to differences in logistics and operating costs; well-known brands may have higher prices than ordinary brands due to their advantages such as quality control and after-sales services.
To obtain the exact market price of this substance, it is necessary to carefully check the real-time quotations of chemical product trading platforms and consult relevant dealers and manufacturers in order to obtain more accurate price information.