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What are the main effects of Sodium Colistinemethanesulfonate?
Sodium Colistinemethanesulfonate, namely polymyxin E sodium methanesulfonate, this drug has unique efficacy and extraordinary effect. Its main function is to fight bacterial infections.
Polymyxin E sodium methanesulfonate is particularly effective against many Gram-negative bacteria. Such as Escherichia coli, Klebsiella, Pseudomonas aeruginosa, etc., are the objects of its restraint. The drug can adhere to the bacterial cell membrane, change the permeability of the membrane, and leak important substances in the bacteria, so as to achieve the purpose of sterilization.
In clinical practice, it is often used to treat serious infections caused by Gram-negative bacteria. Such as respiratory tract infection, the patient coughs, expectorates, breath is not smooth, and the lungs are affected by evil, this medicine can enter the lung meridian, clear the evil poison, and clear the airway; urinary tract infection, urinary frequency, astringent pain, damp heat injection, this medicine can infiltrate the damp heat of the coke, relieve symptoms; and abdominal infection, etc., can eliminate the evil poison in the abdomen and make the viscera peaceful.
When using drugs, caution is also required. Because of its possible adverse reactions, such as nephrotoxicity, neurotoxicity, etc. Doctors should carefully observe the patient's body shape, weigh the pros and cons, and use drugs rationally to achieve the best curative effect and protect the patient's well-being.
Who is Sodium Colistinemethanesulfonate for?
Sodium and colistin methanesulfonate are suitable for the population, which is related to the importance of medical treatment. The mixture of the two is mostly suitable for patients who are attacked by multi-drug resistant Gram-negative bacteria. Because of the raging of multi-drug resistant Gram-negative bacteria, ordinary drugs are difficult to suppress, but this mixture can show its effect.
If the lungs are infected, if the multi-drug resistant Gram-negative bacteria cause pneumonia, the symptoms are hot topic, asthma, phlegm, and difficulty breathing, this mixture may relieve their distress. And urinary tract infections, if the bacteria are multi-drug resistant Gram-negative bacteria, see frequent urination, urgency, urinary pain, or even hematuria, can also be used.
Furthermore, in the intensive care unit, the patient's condition is critical, the immunity is weak, and it is easy to be invaded by multi-drug resistant Gram-negative bacteria. This mixture is often used by doctors to help patients in distress. When using it, the doctor must carefully examine the patient's physical condition, such as liver and kidney function. If the liver and kidney are damaged, the medication needs to be used with caution. The amount and duration of the medication must be accurately controlled to prevent the drug from harming the patient. In short, sodium and colistin methanesulfonate, which are powerful tools for dealing with multi-drug resistant Gram-negative bacteria, should be used with caution and according to the symptoms to achieve the best effect.
What are the side effects of Sodium Colistinemethanesulfonate?
Sodium+Colistinemethanesulfonate is sodium colistin sulfate, and its side effects are as follows:
First, it damages the kidneys. Gu Yun: "The kidney is a strong official, and the trick is to go out." Sodium colistin sulfate can affect the function of the kidney. Common renal tubular damage, proteinuria, hematuria, etc., make the kidney clear and turbid function loss of faculties, the leakage of fine substances, and abnormal urine. Because of the strong nature of the medicine, it directly hurts the renal collaterals, and the essence of the kidney cannot be kept inside, so this is the case.
Second, it can cause abnormal nervous system. The gods of human beings are related to the brain, and the brain depends on the essence of the kidney to replenish. This medicine may disturb the gods, making people dizzy, weak, and even convulsive. The toxicity of the causative medicine follows the meridian into the brain, disrupts the normal function of the brain marrow, and makes the divine mechanism useless, so it has all kinds of manifestations.
Third, it can cause intestinal flora imbalance. The spleen and stomach are the foundation of acquired, the source of qi and blood biochemistry, and the flora in the intestines are harmonious, so that the spleen and stomach can be transported normally. Colistin sodium sulfate also kills innocent people when it is antibacterial, causing damage to the beneficial flora in the intestines, causing abnormal transportation and transformation of the spleen and stomach. People see diarrhea, abdominal pain and other diseases. Just like in a fertile field, the good and bad are removed, the ecological imbalance is unbalanced, and the crops are unsafe.
Fourth, it also affects the function of the ear. The kidney is opened to the ear, and this medicine may damage the essence of the kidney, and then involve the ear, which can cause tinnitus and hearing loss. Because the essence of the kidney cannot be moisturized on the ear, the ear is disnourished, so the hearing is deaf.
When taking medicine, when carefully weighing the pros and cons, pay close attention to the changes in the body, and if there is any discomfort, seek medical treatment quickly. Do not be negligent, so as to avoid the side effects of the medicine that will cause endless harm.
Sodium Colistinemethanesulfonate how to use it correctly
Sodium colistinemethanesulfonate is a commonly used drug. If you want to use it properly, you should follow the following methods.
Before its indications, this drug is mostly used for serious infections caused by Gram-negative bacteria, especially for Pseudomonas aeruginosa and Escherichia coli. In case of lung infections, urinary tract infections, etc. caused by the corresponding bacteria, it can be used.
The dosage is very critical. Adults are often used, about 2-5mg/kg a day, divided into 2-3 doses. Children's medication is determined according to their weight, about 2-3mg/kg a day, and also divided into 2-3 doses. Do not increase or decrease the dose on your own, so as to avoid poor efficacy or adverse reactions.
The route of administration is also exquisite. You can drip intravenously, dilute the drug in an appropriate amount of infusion, and drip it slowly to make the drug enter the body smoothly and exert its effect. If it is intramuscular injection, pay attention to the cleanliness of the injection site to prevent infection.
During the medication period, the patient's condition must be closely monitored. Check for adverse reactions, such as nephrotoxicity, neurotoxicity, etc. If the patient sees abnormal urine output, mental weakness, etc., inform the doctor as soon as possible so that the medication can be adjusted.
When using this drug in combination with other drugs, be cautious. If used with nephrotoxic drugs such as aminoglycosides, it may increase the risk of kidney damage. Therefore, before taking medication, be sure to inform the doctor of the various drugs being used to prevent drug interaction.
Only in this way can the purpose of safe and effective medication be achieved and the patient can recover.
What are the storage conditions for Sodium Colistinemethanesulfonate?
The method of storage is related to the storage of sodium and colistin methanesulfonate, which is extremely important. Sodium is active, easy to combine with other things, and afraid of moisture. Therefore, the storage of sodium must be protected from water and air. Sodium is often placed in kerosene to eliminate air and water vapor, to keep its quality pure and not change.
As for colistin methanesulfonate, this is a pharmaceutical ingredient, and it should be stored according to its nature. It should be placed in a cool and dark place to avoid heat and light. Heat and light can cause it to decompose and damage its medicinal power. And it must be kept dry in the storage place, because moisture can also affect its quality.
When storing these two, you must choose the appropriate place and observe the conditions according to their nature, so as to keep their quality unchanged and their efficacy intact. Sodium is protected by kerosene, which is isolated from air and water vapor; colistin methanesulfonate is kept in a cool and dry place, avoiding heat and light. In this way, the two can last for a long time and have constant effectiveness.