Competitive Trifluoromethanesulfonate prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at
+8615371019725
or mail to
sales7@alchemist-chem.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: sales7@alchemist-chem.com
As a leading Trifluoromethanesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What chemical reactions is Trifluoromethanesulfonate commonly used for?
Trifluoromethanesulfonate (Trifluoromethanesulfonate), which is widely used in various chemical reactions.
In the field of organic synthesis, it is often used as a substrate for nucleophilic substitution reactions. Cover trifluoromethanesulfonyl is an excellent leaving group with strong leaving ability, which can make nucleophiles easier to attack substrate molecules and promote the smooth progress of the reaction. For example, when aryl halides are difficult to directly participate in nucleophilic substitution reactions, if they are converted into corresponding trifluoromethanesulfonates, the reactivity will be greatly improved, and they can react with many nucleophilic reagents, such as alcohols and amines, to form various carbon-heteroatom bonds, which is of great significance in drug synthesis and material preparation.
Trifluoromethanesulfonate also plays a key role in transition metal-catalyzed reactions. Taking the coupling reaction catalyzed by palladium as an example, aryl trifluoromethanesulfonate can form carbon-carbon bonds with alkenyl and alkyl halides under the action of palladium catalysts and ligands. This reaction condition is relatively mild, with good selectivity, and can efficiently synthesize complex organic molecules. It is widely used in the total synthesis of natural products and the development of new functional materials.
In addition, in some Lewis acid-catalyzed reactions, trifluoromethanesulfonate metal salts can be used as efficient catalysts. Its strong acidity and unique electronic effect can effectively promote the reaction, such as catalyzing the polymerization of olefins, the condensation of aldones and ketones, etc., and improve the reaction rate and yield. In short, trifluoromethanesulfonate plays an indispensable role in many chemical synthesis reactions due to its unique chemical properties.
What are the physical properties of Trifluoromethanesulfonate?
Trifluoromethanesulfonate (Trifluoromethanesulfonate) has various physical properties. It is a colorless to slightly yellow liquid and is relatively stable at room temperature and pressure.
In terms of its boiling point, it varies due to the specific structure, but it is usually in a higher temperature range due to intermolecular forces. Its melting point also varies depending on the specific derivative, and some are low melting point characteristics, which is convenient for operation under specific conditions.
The density of trifluoromethanesulfonate is greater than that of water, and its solubility in water varies. Some are soluble, and some are slightly soluble or poorly soluble. This difference in solubility is due to the different interactions between its molecules and water molecules.
Furthermore, it has a certain degree of volatility, but the degree of volatility is lower than that of some common organic solvents. And it has a certain degree of hygroscopicity, and may absorb water vapor in humid environments.
Its refractive index is also an important physical property, which can be used for the identification and purity analysis of substances. In the field of optics, this property may have certain applications.
In addition, the physical properties such as surface tension of trifluoromethanesulfonate also affect its behavior at the interface, which is relevant to many fields such as materials science and colloid chemistry. All these physical properties make it widely used and valuable in many chemical fields such as organic synthesis, catalysis, and even material preparation.
What should I pay attention to when storing trifluoromethanesulfonate (Trifluoromethanesulfonate)?
Trifluoromethanesulfonate (Trifluoromethanesulfonate) is active. When storing, you must pay attention to many things.
First, avoid water. Because it is easy to hydrolyze in contact with water, it is at risk of deterioration. Therefore, it must be stored in a dry place and tightly sealed to prevent moisture from invading. If it is accidentally contacted with water, it may cause a violent reaction, damage its quality, or cause danger.
Second, it needs to be protected from heat. This substance can easily decompose when heated, or even cause safety accidents. It should be stored in a cool place, away from heat sources and open flames. Under high temperatures, its chemical structure is easily damaged and its activity changes, making it impossible to use it for the expected reaction.
Third, do not mix with oxidizing agents, reducing agents and other substances. Trifluoromethanesulfonate encounters with such substances, or reacts chemically, there is a risk of explosion. The storage place must be clearly classified to ensure that various chemicals do not interfere with each other.
Fourth, choose a suitable storage container. Corrosion-resistant materials, such as specific plastic or glass containers, should be used to prevent the container from reacting with trifluoromethanesulfonate and affecting its purity and performance.
In short, when storing trifluoromethanesulfonate, beware of water, heat, improper mixing and selecting the right container, so as to keep its properties stable and safe and effective.
What are the methods for preparing trifluoromethanesulfonate (Trifluoromethanesulfonate)?
Trifluoromethanesulfonic anhydride is also an important agent in the process. There are several common methods for its preparation.
One method is to combine trifluoromethanesulfonic acid with phosphorus pentoxide. When trifluoromethanesulfonic acid meets phosphorus pentoxide, the two are combined. Phosphorus pentoxide is also a strong dehydrating agent. In this reaction, phosphorus pentoxide grabs the water in trifluoromethanesulfonic acid and promotes its intermolecular dehydration and condensation, thus forming trifluoromethanesulfonic anhydride. The corresponding formula is roughly as follows:\ (2CF_ {3} SO_ {3} H + P_ {2} O_ {5}\ longrightarrow (CF_ {3} SO_ {3}) _ {2} O + 2HPO_ {3}\). This reaction needs to be controlled at a moderate temperature and carried out in a dry environment to prevent the product from being hydrolyzed.
There are also those who use trifluoromethanesulfonyl chloride and anhydrous carbonate as materials. Trifluoromethanesulfonyl chloride has strong activity and encounters anhydrous carbonates, such as potassium carbonate. The chlorine atom in trifluoromethanesulfonyl chloride interacts with the carbonate in the carbonate, the carbonate is oxidized and the carbon dioxide escapes, and the rest is poly-trifluoromethanesulfonic anhydride. It should be as follows:\ (2CF_ {3} SO_ {2} Cl + K_ {2} CO_ {3}\ longrightarrow (CF_ {3} SO_ {3}) _ {2} O + 2KCl + CO_ {2}\ uparrow\). In this method, the temperature of the reaction must also be paid attention to, and the reagents used need to be dry to avoid side reactions.
In addition, starting with trifluoromethylsulfonyl fluoride and metal fluoride, it can also be obtained. Metal fluorides such as potassium fluoride interact with trifluoromethyl sulfonyl fluoride, and after a series of atomic rearrangements and combinations, trifluoromethanesulfonic anhydride is finally obtained. The process also requires careful control of conditions to ensure smooth reaction.
Various preparation methods have their own strengths and suitability. Users should choose the best according to the convenience of materials, equipment, cost calculation and other factors to obtain pure trifluoromethanesulfonic anhydride.
What are the advantages of Trifluoromethanesulfonate over other sulfonates?
Trifluoromethanesulfonate has many advantages over other sulfonates. Cover trifluoromethanesulfonate is an excellent leaving group in organic chemistry. Because of its conjugated acid trifluoromethanesulfonate, it is highly acidic and one of the strongest known organic acids. This makes trifluoromethanesulfonate highly stable. In many chemical reactions, it is easy to break away from the reaction substrate and promote the smooth progress of the reaction.
In addition, trifluoromethanesulfonate has excellent nucleophilic substitution reactivity. In nucleophilic substitution reactions, because trifluoromethanesulfonate is very easy to leave, nucleophilic testers can attack the substrate efficiently, prompting the reaction to generate the target product quickly and selectively. The synthesis of many complex organic molecules can be easily achieved through the nucleophilic substitution reaction participated by trifluoromethanesulfonate, which greatly improves the efficiency and accuracy of organic synthesis.
In addition, trifluoromethanesulfonate has good stability, is not easy to hydrolyze or deteriorate in air, and is very convenient for storage and operation. In many synthesis processes that require strict reaction conditions, its stability ensures that the reaction can be carried out under relatively mild conditions, reducing the occurrence of side reactions and further improving the purity and yield of the product.
Trifluoromethanesulfonate has shown unparalleled advantages in many fields such as organic synthesis and medicinal chemistry due to its unique departure ability, high nucleophilic substitution activity and good stability. It is a powerful tool for chemists to construct complex organic molecular structures.