Products

Trifluoromethanesulfonic Acid Methyl Ester

Lingxian Chemical

Specifications

HS Code

683653

Name Trifluoromethanesulfonic Acid Methyl Ester
Chemical Formula CF3SO2OCH3
Molecular Weight 164.1
Appearance Colorless liquid
Odor Pungent
Density 1.48 g/cm³
Boiling Point 100 - 101 °C
Melting Point -80 °C
Solubility Reacts with water
Flash Point 10 °C
Vapor Pressure 3.3 kPa (20 °C)
Acidity Strongly acidic
Reactivity Reactive with nucleophiles
Packing & Storage
Packing 100 - gram bottle of Trifluoromethanesulfonic Acid Methyl Ester tightly sealed.
Storage Trifluoromethanesulfonic acid methyl ester should be stored in a cool, well - ventilated area, away from heat, sparks, and flames. It should be stored in tightly closed containers to prevent vapor release. Due to its reactivity, it should be separated from oxidizing agents, bases, and water - containing substances. Compliance with safety regulations ensures proper and safe storage.
Shipping Trifluoromethanesulfonic Acid Methyl Ester is a hazardous chemical. Shipping requires special packaging compliant with regulations, proper labeling, and transport via carriers licensed to handle such chemicals to ensure safety during transit.
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Trifluoromethanesulfonic Acid Methyl Ester
General Information
Historical Development
"The Origin of Chemicals"
The research of chemical compounds has always been important to our generation. Today, Trifluoromethanesulfonic Acid Methyl Ester, its origin is also interesting.
In the past, Zhu Xian explored in the transformation realm, but he had not heard of this thing at first. After several years of study, Zhu Gong occasionally got clues in various experiments. At that time, Zhu Xian was determined to persevere, tried and tried again, and began to gain.
From the initial ignorance, to gradually understanding its nature, and the preparation method has been improved. Everyone worked hard and moved forward unremittingly, so that the preparation of this thing gradually matured. Its use has also expanded with the expansion of cognition, emerging in various fields, adding a pearl to the forest of chemical compounds. It is actually the cohesion of the efforts of various sages and a witness to the development of transformation.
Product Overview
"Chemical Description"
There is now a product named methyl trifluoromethanesulfonate, which is necessary for synthesis. This color is clear and transparent, with a special taste. Its sexual activity, in the reaction, is often a catalyst for chemical promotion, and it has many reactions and effects.
Methyl trifluoromethanesulfonate, containing trifluoromethyl, this basic property is special, making it an extraordinary effect on chemical reactions. It can be used for alkylation. It can add specific groups to the compound and change its properties.
In the room, it must be used with caution. Because of its high activity, a little carelessness, or accidents. However, if you make good use of it, you can research and synthesize new fields, and then expand the way, and the thing of assisting is booming.
Physical & Chemical Properties
Methyl trifluoromethanesulfonate (Trifluoromethanesulfonic Acid Methyl Ester) is an important reagent in organic chemistry. It is active and has strong chemical activity. At room temperature, it is a colorless and transparent liquid with a special odor. Its boiling point is quite low, about 80 and 2 degrees Celsius, and its density is larger than that of water, about 1.65 grams per cubic centimeter.
In chemical reactions, methyl trifluoromethanesulfonate is often a methylating agent, and its sulfonate group is very good. It can react smoothly with a variety of nucleophilic reagents. And it has high stability and can be well dissolved in many organic solvents, which is conducive to the reaction. However, it is toxic. When using, when operating with caution, strictly follow safety procedures to prevent harm to people and the environment.
Technical Specifications & Labeling
"On the Technical Specification and Labeling (Product Parameters) of Methyl Trifluoromethanesulfonate"
Now, the technical specification of methyl trifluoromethanesulfonate is the key. When preparing, it is necessary to follow a precise method, the material ratio must be appropriate, and the reaction temperature and duration must be fixed. If the material is added in sequence, first and then, it must not be wrong, in order to ensure the purity and yield of the product.
As for the label, the product parameters should be clear and clear. From the appearance point of view, it should be colorless and transparent, with no visible impurities. Its purity must reach a specific standard, and the water content and impurity content are strictly limited. On the packaging, warning labels are also indispensable, because they are dangerous to prevent inadvertent misuse. In this way, the standard of technical specifications and labels makes this object safe and effective when applied.
Preparation Method
Methyl trifluoromethanesulfonate is made today, and the first raw material is selected. When trifluoromethanesulfonate and methanol are used as the basis, both of them need to be pure, and impurities should be removed to ensure the quality of the product.
Its preparation process, mix the two in a suitable container. The temperature is controlled at a specific degree, and it should not be too dramatic or too slow. When the reaction is completed, stir well to make it fully blend.
The reaction step is to first put the raw materials into the reactor in proportion, slowly heat up, and observe the reaction situation. After the reaction is completed, separate and purify in an appropriate way, except for the unwanted substances and by-products.
Catalytic mechanism, an appropriate amount of catalyst can be introduced to promote the rapid progress of the reaction, reduce time and improve efficiency. However, the choice of catalyst must be suitable for this reaction and do not cause other changes. In this way, high-purity methyl trifluoromethanesulfonate can be obtained.
Chemical Reactions & Modifications
The rise of modern chemistry, in the study of material changes, has been advancing day by day. Now Trifluoromethanesulfonic Acid Methyl Ester, its chemical reaction and variability are quite important to researchers.
Its reaction is also, or in case of nucleophiles, the bond is easily broken and new bonds are formed, such as alcohols and the genus of generative ethers, which is the reaction of nucleophilic substitution. Its variability is also related to temperature and solvent conditions. Under high temperature, the reaction rate is fast, and the polarity of the solvent can also affect its process.
To improve its performance, it is necessary to study its reaction mechanism in detail. Knowing the strength of its bonds and the distribution of its electron cloud can then find ways to optimize it. Either change the reaction conditions, or add catalysts to obtain better yield and purity, this is the task of our generation of chemical researchers.
Synonyms & Product Names
Today there is a thing called Trifluoromethanesulfonic Acid Methyl Ester. This thing has a wide range of uses in the field of chemistry. Its aliases and trade names are also different.
In various ancient books, or those who call it methyl trifluoromethanesulfonate, this is one end of the aliases. And between market and business, the trade names set by merchants also vary according to their business convenience.
However, whether it is an alias or a trade name, it all refers to the same thing. The delicacy of chemistry can be seen here. All kinds of names, although different words, in fact refer to the same thing, like a thousand streams returning to the sea, all things are unified. This Trifluoromethanesulfonic Acid Methyl Ester, which is often studied by those of us who study chemistry, so that when we study and apply it, it is correct and smooth.
Safety & Operational Standards
Trifluoromethanesulfonic Acid Methyl Ester is an extremely important reagent in the field of organic synthesis. It has unique chemical properties and plays a key role in many reactions. At the same time, it is also accompanied by certain hazards, so it is necessary to strictly follow the safety and operation norms.
From a safety point of view, this substance is highly corrosive. Contact with the skin can cause severe burns, damage to skin tissue, causing severe pain and difficult-to-heal wounds. If it is not accidentally entered into the eyes, it is even more harmful, or causes irreversible damage to the eyes and even blindness. The evaporated vapor is also highly irritating to the respiratory tract. After inhalation, it can cause symptoms such as cough and breathing difficulties. Long-term or heavy inhalation may cause permanent damage to respiratory organs such as the lungs.
In terms of operating practices, it is essential to operate in a well-ventilated environment. The laboratory should be equipped with high-efficiency ventilation equipment to ensure that the vapor is discharged in time, reduce the concentration in the air, and reduce the risk of inhalation. Operators must wear protective clothing. This protective clothing must be corrosion-resistant and can effectively block the substance from coming into contact with the skin. At the same time, protective gloves need to be worn. The material of the gloves needs to be able to resist its corrosion and fit tightly on the wrist to prevent liquid from flowing in. Eye protection is indispensable. Goggles should be worn to protect the eyes from splashing liquids in all aspects.
When taking methyl trifluoromethanesulfonate, the action should be stable and accurate. Use a suitable pipette or dropper to avoid liquid overflow during the dumping process. If a leak occurs accidentally, emergency measures should be taken immediately. First, quickly evacuate unrelated personnel to prevent more people from coming into contact with the danger. Next, use inert adsorption materials, such as vermiculite, sand, etc., to cover the leak to prevent its spread. After that, the adsorption material is properly collected and disposed of according to relevant regulations.
To sum up, when using methyl trifluoromethanesulfonate, it is necessary to always put safety first and strictly follow the operating instructions to ensure the smooth progress of the experiment, while ensuring the safety of personnel and the environment.
Application Area
Today there is a product called Trifluoromethanesulfonic Acid Methyl Ester. It is widely used in the field of chemical industry. In the way of organic synthesis, it is often used as a reagent to help various reactions. If it meets with alcohols, it can initiate the transformation of esterification and form different esters. It is very useful in the manufacturing of fragrances, medicine and other industries. In the realm of catalysis, it can develop magical power, promote the rapid reaction, and improve the yield. In the process of material creation, it also has its own shadow, helping to make materials with special properties. These applications make Trifluoromethanesulfonic Acid Methyl Ester a key position in the chemical industry and contribute greatly to the evolution of various processes.
Research & Development
Advanced chemistry in modern times, there is a name Trifluoromethanesulfonic Acid Methyl Ester. My generation devoted himself to studying its properties and exploring its uses. At first, I only knew its basic structure, and after years of experiments, I knew that it has extraordinary effectiveness in organic synthesis. It can be used as a strong alkylation reagent to promote various reactions. Those who had difficulty reacting in the past used this substance to intervene, and it can be smooth.
Looking at its development, it has been poorly understood since the beginning, and it is widely used today. It really depends on the unremitting research of colleagues. At the beginning, the preparation was difficult and costly, but after repeated exploration and improvement of the process, it can now be efficiently produced and the cost is controlled. And its application field is expanding day by day, and it has emerged in the pharmaceutical and material industries. In the future, we should still forge ahead and look forward to further development, contributing to the progress of various industries.
Toxicity Research
Toxicity of trifluoromethanesulfonic acid methyl ester. This agent is a commonly used reagent in organic synthesis. After various experiments, it has a certain toxicity. In animal experiments, if exposed to this agent, it may cause shortness of breath and slow movement in light cases, and life-threatening in severe cases.
Its toxicology may involve interfering with the normal biochemical reactions in organisms. If it affects the activity of key enzymes in cell metabolism, it will cause cell dysfunction. And this agent also irritates the skin and mucous membranes. If touched inadvertently, the skin can be red, painful, and the eyes will sting and tear.
Because of the toxicity of this substance, it is essential for safe use and protection. When handling this substance, strictly follow the procedures and prepare for protection to avoid harm.
Future Prospects
Today, there is a product named Trifluoromethanesulfonic Acid Methyl Ester, which in our eyes holds great promise for future expansion. This chemical product has unique properties and can lead to many changes.
Looking at its characteristics, in the chemical industry, it can be used as a catalytic agent to speed up the reaction and increase the yield. The future industry may rely on its strength to make production efficient and save material consumption. In the field of medicine, it is also expected to become a sharp tool for research and development, helping new drugs come out and treat the suffering of the world.
Furthermore, in the research of materials, it may be able to use its properties to make exotic materials for use in aerospace and electronics, making the progress of science and technology more rapid. Although there may be thorns in the road ahead, we chemical researchers should make every effort to explore its potential, look forward to the future, shine brightly, and be used by the world to promote the progress of civilization and benefit all living beings.
Frequently Asked Questions
What are the main uses of Trifluoromethanesulfonic Acid Methyl Ester?
Methyl trifluoromethanesulfonate has a wide range of uses. In the field of organic synthesis, it is often used as a methylation reagent. Because trifluoromethanesulfonyl is an excellent leaving group, it can smoothly transfer methyl groups to various substrates, and plays a significant role in the construction of carbon-carbon bonds and carbon-hetero bonds. In many drug synthesis pathways, methyl trifluoromethanesulfonate is often used to introduce methyl groups to optimize the activity, metabolic stability and bioavailability of drug molecules. For example, in the preparation of some anti-cancer drugs and anti-infective drugs, this reagent plays a key role.
It also has important uses in the field of materials science. In the preparation of functional materials, it can be used to modify polymers or other materials. Through methylation reactions, the physical and chemical properties of materials can be changed, such as improving the solubility, thermal stability and electrical properties of materials. For example, in the synthesis of organic semiconductor materials, the use of methyl trifluoromethanesulfonate for modification can improve the carrier mobility of materials, thereby enhancing the application performance of materials in electronic devices.
In addition, in the field of catalytic chemistry, methyl trifluoromethanesulfonate sometimes participates in catalytic reactions, or is combined with metal catalysts as a ligand, which affects the activity and selectivity of catalysts and helps to carry out catalytic reactions more efficiently and specifically. Overall, methyl trifluoromethanesulfonate plays an indispensable role in many fields such as organic synthesis, materials science, and catalytic chemistry, and is of great significance in promoting the development of related fields.
Trifluoromethanesulfonic the physical properties of Acid Methyl Ester
Methyl trifluoromethanesulfonate is a commonly used reagent in organic synthesis. Its physical properties are many, and this is Jun Chenzhi.
Looking at its properties, at room temperature and pressure, methyl trifluoromethanesulfonate is a colorless and transparent liquid with a clear appearance. Smell it, or have a special smell, but this smell is not particularly extreme irritation.
As for its melting point, the melting point is quite low, about -32 ° C, and the boiling point is between 49-50 ° C. Such melting and boiling point characteristics make it easy to be liquid at room temperature and relatively easy to gasify.
In terms of density, the density of this substance is greater than that of water, about 1.48 g/cm ³. This property causes it to sink underwater if it is mixed with water.
Solubility is also an important property. Methyl trifluoromethanesulfonate is soluble in a variety of organic solvents, such as ether, dichloromethane, etc. However, in water, its solubility is limited, and it may react slowly in contact with water, hydrolyzing to produce products such as trifluoromethanesulfonic acid.
In addition, its vapor pressure has a specific value at a certain temperature. Due to the existence of vapor pressure, its vapor may reach a certain concentration in a closed space. And because it has a certain volatility, it will gradually evaporate in the air. This property requires special attention when storing and using.
Furthermore, the refractive index of methyl trifluoromethanesulfonate also has a specific value, which is of great reference value in identification and purity detection. In summary, these physical properties have a significant impact on the application of methyl trifluoromethanesulfonate in the fields of organic synthesis and chemical production.
Trifluoromethanesulfonic Acid Methyl Ester Chemically Stable?
Trifluoromethanesulfonic trifluoromethanesulfonate methyl (Trifluoromethanesulfonic Acid Methyl Ester), the stability of its chemical properties is really related to many ends. This substance contains trifluoromethyl and has strong electronegativity, which makes its chemical behavior unique.
Looking at its structure, trifluoromethanesulfonyl is connected to methyl. The strong electron-absorbing properties of trifluoromethyl make the electron clouds in the molecule different. This structural feature makes it active in many chemical reactions.
However, in terms of stability, under normal conditions, methyl trifluoromethanesulfonate is quite stable. Its carbon-sulfur bond and carbon-fluorine bond energy are quite high, giving the molecule the power to resist ordinary chemical reactions.
When encountering a specific reagent, the stability changes. In case of a strong nucleophilic reagent, the methyl group can be attacked by nucleophilic, causing ester bond breakage. This is because the ester group has a certain affinity for the nucleophilic reagent.
High temperature or strong radiation environment may also affect its stability. High temperature can increase molecular kinetic energy, making chemical bonds more prone to fracture; strong radiation can cause electron excitation, destroy the original electron distribution, and damage its stability.
In summary, the stability of methyl trifluoromethanesulfonate is non-absolute and varies according to environmental conditions and the reagents encountered. Although it can maintain stability under common circumstances, its structure may change under specific chemical scenarios.
Trifluoromethanesulfonic Acid Methyl Ester when storing
Methyl trifluoromethanesulfonate is a commonly used reagent in organic synthesis. When storing, many precautions should be kept in mind.
First, this material is highly corrosive and toxic. It must be stored in a special storage area, away from frequent personnel, and the area should be dry, cool and well ventilated. Because it is prone to severe reactions in contact with water, it is necessary to strictly waterproof to ensure that the humidity of the storage environment is maintained at an extremely low level.
Second, methyl trifluoromethanesulfonate is quite sensitive to light, and light can easily cause it to decompose or other adverse reactions. Therefore, it should be stored in dark containers such as brown bottles to prevent direct light exposure.
Third, the storage container must have a good seal to prevent its volatilization and escape. Because the volatile gas not only endangers human health, but also may form an explosive mixture with the air, causing safety accidents.
Fourth, the objects stored adjacent to it must be avoided from chemical reactions with them. Substances such as strong oxidants and strong bases must not be placed in one place with methyl trifluoromethanesulfonate to prevent accidents.
Fifth, the storage place should be equipped with complete emergency treatment equipment, such as adsorbents, neutralizers, etc., in case of leakage and other accidents, it can be dealt with quickly and reduce hazards. Managers should also be familiar with emergency treatment procedures so that they can respond correctly in emergency situations.
What is the preparation method of Trifluoromethanesulfonic Acid Methyl Ester?
The method of preparing methyl trifluoromethanesulfonate is not detailed in ancient books, but according to the current chemical principles, the following paths may be followed.
First, trifluoromethanesulfonate and methanol are used as the starting materials, and an appropriate catalyst is added to carry out the esterification reaction. Under appropriate temperature and pressure, the two are combined. Among them, sulfuric acid is often a useful catalyst, which can increase the rate of reaction. However, sulfuric acid is highly corrosive, and it should be operated with caution. The reaction formula is about: CF SO < unk > H + CH < unk > OH < unk > CF < unk > SO < unk > CH + H < unk > O. This reaction is reversible, and the product with high yield can be obtained, or the method of removing the water generated by the reaction can be used to promote the equilibrium to move to the side of the product, such as azeotropic distillation to remove the water.
Second, trifluoromethanesulfonyl chloride and sodium methoxide can also be used as raw materials. The trifluoromethanesulfonyl chloride and sodium methoxide meet in a suitable solvent and perform a substitution reaction. This solvent often takes ethers, such as ether and tetrahydrofuran, because it has good solubility to the reactants and products, and its chemical properties are relatively stable. Its reaction formula is: CF < unk > SO < unk > Cl + CH < unk > ONa → CF < unk > SO < unk > CH + NaCl. The reaction conditions of this route are milder, and the purity of the product may be higher. However, trifluoromethanesulfonyl chloride is highly irritating and corrosive, and sodium methoxide is also active. The operation requires strict protection and precise temperature and quality control.
Preparation of methyl trifluoromethanesulfonate, no matter what method is used, should be safe and fine operation to obtain a pure and sufficient amount of product.