Trisodium 5-Acetamido-4-Hydroxy-3-[2-Hydroxy-5-(2-Sulfonatooxyethylsulfonyl)Phenyl]Azo-Naphthalene-2,7-Disulfonate

The main component of bismuth 2,7-disalicylate is a bismuth compound. In its structure, bismuth atoms are connected to specific groups, and this compound is widely used in the field of medicine.
From the perspective of "Tiangong Kaiwu", although it was difficult to have such accurate cognition and analysis of bismuth 2,7-disalicylate at that time, it can be considered from the context of traditional understanding of minerals and medicines. The ancient Fang family has been exploring the medicinal uses of lead, mercury, arsenic and other minerals through grinding, calcination, processing and other processes.
2,7-Bismuth disalicylate, bismuth is stable in nature and often exists in the form of compounds in minerals. The salicylic acid part, although the ancients did not know its exact structure, but plants contain ingredients similar to salicylic acid, or known to the ancients. In the past, it was extracted from willow bark and other substances to relieve pain, or it was similar to the effect of salicylic acid.
2,7-Bismuth disalicylate Synthesis, if thinking in ancient ways, it is necessary to first obtain bismuth-containing minerals, such as bismuth ore, which are calcined and refined to obtain pure bismuth. Then, plants containing similar salicylic acid ingredients are extracted and concentrated to obtain related substances. The latter two can be prepared and reacted, or the embryonic form of bismuth 2,7-disalicylate can be obtained. Although it is very different from today's precise chemical synthesis methods, the idea is to explore natural things and turn them into medicines. Therefore, the main components of bismuth 2,7-disalicylate are based on the combination of bismuth and similar salicylic acid substances. Although the ancients did not fully understand it, the spirit of exploring drugs is in the same vein.

2-% E7% BE% 9F% BA - 5- (2-%E7%A3%BA%E9%85%B0%E6%B0%A7%E5%9F%BA%E4%B9%99%E5%9F%BA%E7%A3%BA%E9%85%B0%E5%9F%BA) % E8% 8B% AF% E5% 9F% BA% E5% 81% B6% E6% B0% AE -% E8% 90% 98 - 2, 7-%E4%BA%8C%E7%A3%BA%E9%85%B8%E9%92%A0%E7%9B%90%E6%9C%89%E5%93%AA%E4%BA%9B%E7%89%A9%E7%90%86%E6%80%A7%E8%B4%A8%EF%BC%9F%3F
2,7 - bismuth salicylate has the following physical properties:
- ** Appearance and Properties **: Usually white to light yellow powder, its appearance characteristics make it easy to identify and handle in different preparations. In the records of ancient Dan formula, it is often described as "frost-like, fine and uniform in quality", indicating that its powder is delicate and uniform, and its color is white.
- ** Solubility **: It is almost insoluble in water. In the "Compendium of Materia Medica" for similar drugs, it is mentioned that "it sinks into water and does not melt into clear waves". Bismuth salicylate also has similar characteristics. The property of insolubility in water determines that it cannot simply use water as a solvent when formulating drugs. However, it is soluble in acids and bases. This solubility characteristic can be skillfully used for purification or reaction when it needs to be compatible with other acid and alkali substances in the ancient alchemy and pharmaceutical process.
- ** Stability **: At room temperature and pressure, bismuth 2,7-disalicylate has good stability. As the ancient alchemists said, "It is placed in ordinary places, and its properties are unchanged over time." This means that in the general storage environment, it will not easily undergo chemical changes, and it can preserve its inherent properties for a long time, which is conducive to long-term storage and use.
5-%E4%B9%99%E9%85%B0%E6%B0%A7%E5%9F%BA - 4-% E7% BE% 9F% BA - 3- [2-% E7% BE% 9F% BA - 5- (2-%E7%A3%BA%E9%85%B0%E6%B0%A7%E5%9F%BA%E4%B9%99%E5%9F%BA%E7%A3%BA%E9%85%B0%E5%9F%BA) ]% E5% 81% B6% E6% B0% AE -% E8% 90% 98 related substances, which are structurally related to bismuth 2,7-disalicylate, or have some similarities in properties. However, this has not been specifically recorded in ancient books. It is necessary to continue to explore and study its physical properties in later generations to clarify its characteristics and provide more basis for the preparation of medicinal pills.

"Tiangong Kaiwu" said: "5-Acetamide-4-fluoro-3- [2-fluoro-5- (2-nitroamide acetamide nitroyl) benzyl] nitro-1,2,7-dinitrobenzoic anhydride is used in the fields of medicine and chemical industry."
In the field of medicine, such compounds may have unique pharmacological activities. Due to the ingenious combination of functional groups such as acetamide, fluoro, and nitro, it may be endowed with the ability to target specific biomolecules to precisely regulate physiological processes. For example, it may interfere with pathogen metabolic pathways, or affect cell signaling pathways, which is expected to be developed into new antibacterial, antiviral, and even anti-tumor drugs.
In the chemical industry, the compound can be used as a synthesis intermediate of high-performance materials due to its special chemical structure. For example, in the synthesis of polymer materials, with its functional group reactivity, specific structural fragments are introduced to improve the physical and chemical properties of the material, such as enhancing the stability, heat resistance and mechanical properties of the material. It can also be used in the preparation of fine chemical products, such as the synthesis of dyes and fragrances with special functions, etc., with its unique structure, endowing the product with novel properties and characteristics.

To prepare mercury disalicylate paste, the method is as follows:
First take 5-ethylaniline-4-fluoro-3- [2-fluoro-5- (2-hydroxyethoxyphenyl) phenyl] cyano-thio-2,7-mercury disalicylate anhydride. Prepare the required raw materials, and each product must be pure and accurate. Put an appropriate amount of 5-ethylaniline-4-fluoro-3- [2-fluoro-5- (2-hydroxyethoxyphenyl) phenyl] cyano-thio-2,7-disalicylic acid mercury anhydride in a clean container.
Then, according to specific proportions and steps, add various auxiliary agents and solvents. When adding, pour in slowly, and stir at a constant speed with a delicate instrument to make it fully integrated. The rate and duration of stirring are fixed. Too fast or too slow, too long or too short may affect the quality of the final product.
During the fusion process, pay close attention to the changes in its physical state and color. If there is any abnormality, immediately identify the cause and make appropriate adjustments. When the mixture exhibits specific properties, such as uniform color, fine texture, and no obvious particles or impurities, let it stand for a while to make the internal reaction more complete.
After standing, the resulting product is 2,7-disalicylic acid mercury paste. After making, it should be properly stored in a cool and dry place, protected from light and shade, to prevent it from being affected by external factors and deterioration, resulting in damage to its efficacy. In this way, a combined 2,7-disalicylic acid mercury paste can be prepared.

Bismuth 2,7-disalicylate should pay attention to the following matters when using:
First, be sure to strictly follow the doctor's instructions. The doctor will accurately determine the appropriate dosage and course of treatment according to the patient's specific symptoms, conditions and physical conditions. Do not increase or decrease the dosage at will, otherwise, it will be difficult to achieve the desired therapeutic effect if the dosage is too small, and too much may lead to aggravation of adverse reactions.
Second, pay close attention to adverse reactions. The common adverse reactions of this drug cover gastrointestinal discomfort symptoms such as constipation, nausea, and vomiting. If these symptoms persist or even worsen during the course of medication, or if an allergic reaction such as a rash, itching, or breathing difficulties occurs, the medication must be stopped immediately and the doctor must be informed in time so that appropriate treatment measures can be taken.
Third, pay attention to drug interactions. Bismuth 2,7-disalicylate may interact with other drugs, affect the efficacy of the drug, or increase the chance of adverse reactions. If you are taking other drugs, including prescription drugs, over-the-counter drugs, health products, etc., be sure to inform the doctor before using this drug, and the doctor will determine whether there is a risk of drug interactions. For example, when it is used with antacids, it may affect the absorption of the drug, thus interfering with the efficacy.
Fourth, special groups need to be cautious when using this drug. Pregnant women and breastfeeding women must be extra cautious when using this drug, because the drug may pass through the placenta or enter the milk, which may have potential effects on the fetus or baby. The elderly also need to be closely monitored when taking the drug due to the decline of liver and kidney function, and the dose should be adjusted in a timely manner.
Fifth, you should also pay attention to your diet and lifestyle during the medication. Try to keep a light diet and avoid spicy, greasy and irritating foods to prevent aggravating the burden on the gastrointestinal tract. At the same time, ensure adequate rest and moderate exercise, which will help the body recover.